| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | PGR | Ser294 | APMAPGRsPLATTVM | phosphorylation down-regulates | 10655479 | SIGNOR-74712 |
| CDK2 | PGR | Ser294 | APMAPGRsPLATTVM | phosphorylation down-regulates | 10655479 | SIGNOR-74708 |
| MAPK3 | PGR | Ser294 | APMAPGRsPLATTVM | phosphorylation down-regulates | 10655479 | SIGNOR-74716 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | PGR PSer294 | phosphorylation down-regulates ⊣ | PGR | 10655479 | SIGNOR-74712 |
| CDK2 | phosphorylation up-regulates → | PGR PSer294 | phosphorylation down-regulates ⊣ | PGR | 10655479 | SIGNOR-74708 |
| MAPK3 | phosphorylation up-regulates → | PGR PSer294 | phosphorylation down-regulates ⊣ | PGR | 10655479 | SIGNOR-74716 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation down-regulates | PGR | SIGNOR-74712 |
| CDK2 | phosphorylation down-regulates | PGR | SIGNOR-74708 |
| MAPK3 | phosphorylation down-regulates | PGR | SIGNOR-74716 |
