| Name | CDK1 |
| ID | P06493 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 4-287 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKMYT1 | CDK1 | Thr14 | IEKIGEGtYGVVYKG | phosphorylation down-regulates | 9001210 | SIGNOR-45725 |
| CDC25B | CDK1 | – | dephosphorylation up-regulates | 7880537 | SIGNOR-34541 | |
| CDK7 | CDK1 | Thr161 | GIPIRVYtHEVVTLW | phosphorylation up-regulates | 8344251 | SIGNOR-38307 |
| CDC25B | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 25384584 | SIGNOR-276969 |
| CDC25C | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates | 19574738 | SIGNOR-186617 |
| CDC25A | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248480 |
| CDC25A | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248479 |
| WEE2 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates activity | 11029659 | SIGNOR-279134 |
| ERBB2 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 12049736 | SIGNOR-88671 |
| CDC25C | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 17634129 | SIGNOR-276945 |
| CSNK2A1 | CDK1 | Ser39 | MKKIRLEsEEEGVPS | phosphorylation up-regulates | 15788687 | SIGNOR-134846 |
| CDC25B | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 25384584 | SIGNOR-276970 |
| CDC25C | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 24643073 | SIGNOR-276944 |
| PKMYT1 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 9001210 | SIGNOR-45729 |
| PPP4C | CDK1 | – | dephosphorylation down-regulates activity | 18347064 | SIGNOR-277162 | |
| CDC25C | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates | 19574738 | SIGNOR-186621 |
| WEE1 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 16096060 | SIGNOR-139491 |
| CTDP1 | CDK1 | – | dephosphorylation down-regulates activity | 26653855 | SIGNOR-277141 | |
| EIF2AK2 | CDK1 | Tyr4 | yTKIEKIG | phosphorylation down-regulates | 20395957 | SIGNOR-164809 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKMYT1 | phosphorylation up-regulates → | CDK1 PThr14 | phosphorylation down-regulates ⊣ | CDK1 | 9001210 | SIGNOR-45725 |
| CDK7 | phosphorylation up-regulates → | CDK1 PThr161 | phosphorylation up-regulates → | CDK1 | 8344251 | SIGNOR-38307 |
| CDC25B | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 25384584 | SIGNOR-276969 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 19574738 | SIGNOR-186617 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 10454565 | SIGNOR-248480 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 10454565 | SIGNOR-248479 |
| WEE2 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 11029659 | SIGNOR-279134 |
| ERBB2 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 12049736 | SIGNOR-88671 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 17634129 | SIGNOR-276945 |
| CSNK2A1 | phosphorylation up-regulates → | CDK1 PSer39 | phosphorylation up-regulates → | CDK1 | 15788687 | SIGNOR-134846 |
| CDC25B | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 25384584 | SIGNOR-276970 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 24643073 | SIGNOR-276944 |
| PKMYT1 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 9001210 | SIGNOR-45729 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 19574738 | SIGNOR-186621 |
| WEE1 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 16096060 | SIGNOR-139491 |
| EIF2AK2 | phosphorylation up-regulates → | CDK1 PTyr4 | phosphorylation down-regulates ⊣ | CDK1 | 20395957 | SIGNOR-164809 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKMYT1 | phosphorylation down-regulates | CDK1 | SIGNOR-45725 |
| CDC25B | dephosphorylation → up-regulates | CDK1 | SIGNOR-34541 |
| CDK7 | phosphorylation → up-regulates | CDK1 | SIGNOR-38307 |
| CDC25B | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276969 |
| CDC25C | dephosphorylation → up-regulates | CDK1 | SIGNOR-186617 |
| CDC25A | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-248480 |
| CDC25A | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-248479 |
| WEE2 | phosphorylation → down-regulates activity | CDK1 | SIGNOR-279134 |
| ERBB2 | phosphorylation down-regulates | CDK1 | SIGNOR-88671 |
| CDC25C | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276945 |
| CSNK2A1 | phosphorylation → up-regulates | CDK1 | SIGNOR-134846 |
| CDC25B | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276970 |
| CDC25C | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276944 |
| PKMYT1 | phosphorylation down-regulates | CDK1 | SIGNOR-45729 |
| PPP4C | dephosphorylation → down-regulates activity | CDK1 | SIGNOR-277162 |
| CDC25C | dephosphorylation → up-regulates | CDK1 | SIGNOR-186621 |
| WEE1 | phosphorylation down-regulates | CDK1 | SIGNOR-139491 |
| CTDP1 | dephosphorylation → down-regulates activity | CDK1 | SIGNOR-277141 |
| EIF2AK2 | phosphorylation down-regulates | CDK1 | SIGNOR-164809 |