Summary

Name CDK1
Full Name Cyclin-dependent kinase 1
Synonyms CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase | CDC2, CDC28A, CDKN1, P34CDC2
Primary ID P06493
Links - -
Type protein
Relations 423
Pathways Acute Myeloid Leukemia, IDH-TET in AML, KIT in AML, YAP/TAZ regulation
Inhibitors 4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine; N-[6,6-dimethyl-5-[(1-methyl-4-piperidinyl)-oxomethyl]-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-methylbutanamide; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide; R547; 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide; seliciclib; BMS-265246; Dinaciclib; alvocidib; alvocidib hydrochloride; UNII-XH2662798I
Function Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230). Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation KMT5A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FMNL2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png phosphorylation RAB11FIP3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EGFR 0.427
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation PRPS1 0.255
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation EP300 0.405
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates quantity img/direct_inhibition.png phosphorylation EP300 0.405
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation BCL2L11 0.406
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MPLKIP 0.341
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDUFV3 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation WWTR1 0.258
Publications: 4
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation WWTR1 0.258
Publications: 3 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png phosphorylation DUT (isoform 2) 0.386
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RCC1 0.506
Publications: 4 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TOP1 0.35
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation ESPL1 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R13L 0.507
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC25A 0.842
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BRCA1 0.498
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NME1 0.266
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation UBE2A 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC25C 0.858
Publications: 11 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WEE1 0.858
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAB5B 0.327
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CLASP2 0.567
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CUX1 0.358
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ img/unknown.png phosphorylation TOP2A 0.527
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AMBRA1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDCA5 0.709
Publications: 6 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation TK1 0.508
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation EEF1D 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation YAP1 0.426
Publications: 3
+ down-regulates activity img/direct_inhibition.png phosphorylation NSFL1C 0.326
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation KDM5B 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DNMT1 0.3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IREB2 0.354
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DLG1 0.394
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC25B 0.829
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation USP24 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTTG2 0.291
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTTG1 0.6
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP53BP1 0.602
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CDC25C 0.858
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NUCKS1 0.476
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation NINL 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FEN1 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NUP210 0.547
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation STIP1 0.265
Publications: 3 Organism: Mus Musculus
+ img/unknown.png phosphorylation RRM2 0.505
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MYOD1 0.366
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CC2D1A 0.2
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CSNK2B 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX1 0.342
Publications: 5 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation ABI1 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LMNA 0.538
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NUP50 0.418
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RANBP2 0.471
Publications: 5 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation RPA2 0.509
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.658
Publications: 3 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.513
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates img/direct_inhibition.png phosphorylation FOXO1 0.513
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RB1 0.687
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RECQL4 0.356
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXM1 0.76
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TOB2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation USP9X 0.279
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation ORC1 0.635
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PIK3C2A 0.282
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PDCD1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation CREM 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SQSTM1 0.344
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GORASP1 0.714
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation RUNX1 0.342
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.342
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CREM 0.297
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation RAD9A 0.363
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SLC9A3R1 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CHEK1 0.411
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDUFB6 0.2
Publications: 3
+ img/unknown.png phosphorylation PTPN2 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CGAS 0.2
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation DES 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation USP1 0.372
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation TP53 0.581
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML, KIT in AML
+ up-regulates img/direct-activation.png phosphorylation E2F1 0.699
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SUN1 0.359
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KRT18 0.339
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAPK3 (isoform 3) 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ANAPC1 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EEF2K 0.369
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGA1 0.385
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CSNK2A1 0.356
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDUFS2 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation SIRT2 0.413
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation GOLGA2 0.672
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOXK2 0.373
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EPN1 0.323
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation PITPNM1 0.466
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PTPN1 0.504
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN1 0.504
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.362
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates img/direct-activation.png phosphorylation FANCG 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK1 0.356
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KB1 0.385
Publications: 6 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation ZC3HC1 0.253
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation UBA1 0.406
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PPM1D 0.348
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CEP55 0.451
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC27 0.703
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RANGAP1 0.492
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KRT8 0.248
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SREBF1 0.288
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HMGA2 0.375
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEDD1 0.583
Publications: 2 Organism: , Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation REPS2 0.341
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates img/direct-activation.png phosphorylation RUNX2 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SYN3 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAP1GAP 0.447
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PKN1 0.433
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAPOLA 0.259
Publications: 3 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SIRT1 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K11 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CDC14A 0.542
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation VIM 0.363
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation USP16 0.456
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation UBXN2B 0.2
Publications: 2
+ up-regulates img/direct-activation.png phosphorylation CDC16 0.636
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TSC1 0.491
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation TSC1 0.491
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NINL 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation KIFC1 0.459
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation NUP98 0.399
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LATS1 0.391
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation ATAD5 0.24
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation STIM1 0.346
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CENPA 0.678
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK6 0.482
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MAP4 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP4 0.499
Publications: 3 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPTOR 0.386
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NPM1 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation LBR 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NCOA3 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LIG1 0.364
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation VCPIP1 0.535
Publications: 2
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP6R2 0.261
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP4 0.499
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation VHL 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ODF2 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AR 0.533
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KAT5 0.48
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ up-regulates activity img/direct-activation.png phosphorylation BAD 0.2
Publications: 1
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation MDM4 0.408
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ERCC6L 0.577
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF4A 0.49
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDUFA12 0.2
Publications: 2
+ down-regulates img/direct_inhibition.png phosphorylation PTHLH 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CASP9 0.43
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HASPIN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NFAT5 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDK1 0.842
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CDK1 0.858
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDK1 0.858
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CDK1 0.829
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.751
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PIK3C3 0.421
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDK1 0.579
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF20B 0.41
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GATA2 0.356
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TFCP2L1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DCTN6 0.308
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation MCM4 0.593
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MASTL 0.51
Publications: 2 Organism: Xenopus Laevis
+ down-regulates activity img/direct_inhibition.png phosphorylation NPM1 0.52
Publications: 6 Organism: Homo Sapiens, Mus Musculus
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png phosphorylation DDX3X 0.297
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NUMA1 0.585
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NEK9 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS3 0.363
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NIFK 0.28
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation WAC 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TERT 0.324
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RNF138 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP2K1 0.493
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CLIP1 0.487
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation NUSAP1 0.432
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KHDRBS1 0.535
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PPP1CA 0.573
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RRM2 0.505
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BIRC5 0.684
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EZH2 0.576
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation SGO1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SKA3 0.394
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ECT2 0.578
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDC7 0.537
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDUFV1 0.2
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation INCENP 0.758
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ECT2 0.578
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PLEC 0.389
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF22 0.344
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RFC1 0.246
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation EIF4G2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.684
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BCL2 0.346
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ up-regulates img/direct-activation.png phosphorylation CDC23 0.635
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation SAMHD1 0.493
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BUB1 0.86
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TEX14 0.334
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SLBP 0.42
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BUB1B 0.776
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CKAP2 0.288
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.398
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MORC2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TPX2 0.635
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation APLP2 0.334
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation SP1 0.465
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
Pathways:Acute Myeloid Leukemia
+ up-regulates activity img/direct-activation.png phosphorylation AKAP12 0.323
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RNMT 0.255
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KAT7 0.356
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation TP73 0.554
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PBK 0.553
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PRDX1 0.351
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MCL1 0.463
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ up-regulates img/direct-activation.png phosphorylation KIF11 0.64
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KIF11 0.64
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.858
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.274
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDK1 0.329
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png transcriptional regulation CDK1 0.699
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ERF 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding CDK1 0.335
Publications: 1
+ down-regulates activity img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation OSBP2 0.2
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDK1 0.581
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding CDK1 0.379
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDK1 0.542
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation NDE1 0.653
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PP1 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDK1 0.532
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CyclinB/CDK1 1
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation UBE2I 0.514
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation CDK1 0.829
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CDK1 0.333
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MEK1/2 0.493
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2L1 0.539
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CDK1 0.28
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.881
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation RAB1A 0.524
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PML 0.346
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PLK1 0.608
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.709
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation CDK1 0.399
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CDK1 0.658
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, IDH-TET in AML
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ESCO1 0.476
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDE1 0.653
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BCL2 0.346
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ form complex img/form-complex.png binding CyclinA2/CDK1 0.922
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation TAZ 0.267
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation USP22 0.472
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CDK1 0.8
Publications: 1 Organism: Homo Sapiens