| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248480 |
| WEE2 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates activity | 11029659 | SIGNOR-279134 |
| ERBB2 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 12049736 | SIGNOR-88671 |
| CDC25B | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 25384584 | SIGNOR-276970 |
| CDC25C | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates activity | 24643073 | SIGNOR-276944 |
| PKMYT1 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 9001210 | SIGNOR-45729 |
| CDC25C | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | dephosphorylation up-regulates | 19574738 | SIGNOR-186621 |
| WEE1 | CDK1 | Tyr15 | EKIGEGTyGVVYKGR | phosphorylation down-regulates | 16096060 | SIGNOR-139491 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC25A | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 10454565 | SIGNOR-248480 |
| WEE2 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 11029659 | SIGNOR-279134 |
| ERBB2 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 12049736 | SIGNOR-88671 |
| CDC25B | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 25384584 | SIGNOR-276970 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 24643073 | SIGNOR-276944 |
| PKMYT1 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 9001210 | SIGNOR-45729 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PTyr15 | dephosphorylation down-regulates ⊣ | CDK1 | 19574738 | SIGNOR-186621 |
| WEE1 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 16096060 | SIGNOR-139491 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC25A | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-248480 |
| WEE2 | phosphorylation → down-regulates activity | CDK1 | SIGNOR-279134 |
| ERBB2 | phosphorylation down-regulates | CDK1 | SIGNOR-88671 |
| CDC25B | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276970 |
| CDC25C | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276944 |
| PKMYT1 | phosphorylation down-regulates | CDK1 | SIGNOR-45729 |
| CDC25C | dephosphorylation → up-regulates | CDK1 | SIGNOR-186621 |
| WEE1 | phosphorylation down-regulates | CDK1 | SIGNOR-139491 |
