| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKMYT1 | CDK1 | Thr14 | IEKIGEGtYGVVYKG | phosphorylation down-regulates | 9001210 | SIGNOR-45725 |
| CDC25B | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 25384584 | SIGNOR-276969 |
| CDC25C | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates | 19574738 | SIGNOR-186617 |
| CDC25A | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 10454565 | SIGNOR-248479 |
| CDC25C | CDK1 | Thr14 | IEKIGEGtYGVVYKG | dephosphorylation up-regulates activity | 17634129 | SIGNOR-276945 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKMYT1 | phosphorylation up-regulates → | CDK1 PThr14 | phosphorylation down-regulates ⊣ | CDK1 | 9001210 | SIGNOR-45725 |
| CDC25B | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 25384584 | SIGNOR-276969 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 19574738 | SIGNOR-186617 |
| CDC25A | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 10454565 | SIGNOR-248479 |
| CDC25C | dephosphorylation down-regulates ⊣ | CDK1 PThr14 | dephosphorylation down-regulates ⊣ | CDK1 | 17634129 | SIGNOR-276945 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKMYT1 | phosphorylation down-regulates | CDK1 | SIGNOR-45725 |
| CDC25B | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276969 |
| CDC25C | dephosphorylation → up-regulates | CDK1 | SIGNOR-186617 |
| CDC25A | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-248479 |
| CDC25C | dephosphorylation → up-regulates activity | CDK1 | SIGNOR-276945 |
