| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MKNK1 | EIF4E | Ser209 | DTATKSGsTTKNRFV | phosphorylation up-regulates | 17724079 | SIGNOR-157533 |
| MTOR | EIF4E | – | phosphorylation down-regulates activity | 35697076 | SIGNOR-278963 | |
| PRKCA | EIF4E | Ser209 | DTATKSGsTTKNRFV | phosphorylation up-regulates | 8662663 | SIGNOR-248945 |
| PRKCG | EIF4E | Ser209 | DTATKSGsTTKNRFV | phosphorylation unknown | 8662663 | SIGNOR-248947 |
| MKNK2 | EIF4E | Ser209 | DTATKSGsTTKNRFV | phosphorylation up-regulates | 17724079 | SIGNOR-157537 |
| PRKCB | EIF4E | Ser209 | DTATKSGsTTKNRFV | phosphorylation up-regulates | 8662663 | SIGNOR-248946 |
| MKNK1 | EIF4E | – | phosphorylation up-regulates | 20626350 | SIGNOR-166646 | |
| MKNK1 | EIF4E | – | phosphorylation up-regulates | 9878069 | SIGNOR-62936 | |
| PPP2CA | EIF4E | Ser209 | DTATKSGsTTKNRFV | dephosphorylation down-regulates | 20927323 | SIGNOR-168306 |
| AURKA | EIF4E | – | phosphorylation up-regulates activity | 28073841 | SIGNOR-279495 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MKNK1 | phosphorylation up-regulates → | EIF4E PSer209 | phosphorylation up-regulates → | EIF4E | 17724079 | SIGNOR-157533 |
| PRKCA | phosphorylation up-regulates → | EIF4E PSer209 | phosphorylation up-regulates → | EIF4E | 8662663 | SIGNOR-248945 |
| PRKCG | phosphorylation up-regulates → | EIF4E PSer209 | phosphorylation down-regulates ⊣ | EIF4E | 8662663 | SIGNOR-248947 |
| MKNK2 | phosphorylation up-regulates → | EIF4E PSer209 | phosphorylation up-regulates → | EIF4E | 17724079 | SIGNOR-157537 |
| PRKCB | phosphorylation up-regulates → | EIF4E PSer209 | phosphorylation up-regulates → | EIF4E | 8662663 | SIGNOR-248946 |
| PPP2CA | dephosphorylation down-regulates ⊣ | EIF4E PSer209 | dephosphorylation up-regulates → | EIF4E | 20927323 | SIGNOR-168306 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MKNK1 | phosphorylation → up-regulates | EIF4E | SIGNOR-157533 |
| MTOR | phosphorylation → down-regulates activity | EIF4E | SIGNOR-278963 |
| PRKCA | phosphorylation → up-regulates | EIF4E | SIGNOR-248945 |
| PRKCG | phosphorylation → unknown | EIF4E | SIGNOR-248947 |
| MKNK2 | phosphorylation → up-regulates | EIF4E | SIGNOR-157537 |
| PRKCB | phosphorylation → up-regulates | EIF4E | SIGNOR-248946 |
| MKNK1 | phosphorylation → up-regulates | EIF4E | SIGNOR-166646 |
| MKNK1 | phosphorylation → up-regulates | EIF4E | SIGNOR-62936 |
| PPP2CA | dephosphorylation down-regulates | EIF4E | SIGNOR-168306 |
| AURKA | phosphorylation → up-regulates activity | EIF4E | SIGNOR-279495 |
