| + |
MKNK2 | up-regulates 
phosphorylation
|
EIF4E |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157537 |
Ser209 |
DTATKSGsTTKNRFV |
Homo sapiens |
|
| pmid |
sentence |
| 17724079 |
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and mnk-mediated eukaryotic translation initiation factor 4e phosphorylation.Therefore, eif4e is considered a survival protein involved in cell cycle progression, cell transformation, and apoptotic resistance. Phosphorylation of eif4e (usually at ser209) increases its binding affinity for the cap of mrna and may also favor its entry into initiation complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2CA | down-regulates 
dephosphorylation
|
EIF4E |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168306 |
Ser209 |
DTATKSGsTTKNRFV |
Homo sapiens |
|
| pmid |
sentence |
| 20927323 |
A recent study using genetically engineered mouse models has clearly shown that mnk-mediated eif4e phosphorylation is absolutely required for eif4e's oncogenic action. Taken together, we conclude that pp2a negatively regulates eif4e phosphorylation and eif4f complex assembly through dephosphorylation of mnk and eif4e, thus suggesting a novel mechanism by which pp2a exerts its tumor-suppressive function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES |
| + |
MKNK1 | up-regulates
phosphorylation
|
EIF4E |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157533 |
Ser209 |
DTATKSGsTTKNRFV |
Homo sapiens |
|
| pmid |
sentence |
| 17724079 |
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and mnk-mediated eukaryotic translation initiation factor 4e phosphorylation.Therefore, eif4e is considered a survival protein involved in cell cycle progression, cell transformation, and apoptotic resistance. Phosphorylation of eif4e (usually at ser209) increases its binding affinity for the cap of mrna and may also favor its entry into initiation complexes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62936 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9878069 |
Mnk1 and mnk2 regulate protein synthesis by phosphorylating the initiation factor eif4e. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166646 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Mnk1 and mnk2 regulate protein synthesis by phosphorylating the initiation factor eif4e. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | PI3K/AKT Signaling |
| + |
PRKCA | up-regulates
phosphorylation
|
EIF4E |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248945 |
Ser209 |
DTATKSGsTTKNRFV |
Mus musculus |
|
| pmid |
sentence |
| 8662663 |
Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.[..] This suggests a two-step model for the phosphorylation (and activation) of eIF4E by growth factors and hormones: first, dissociation of eIF4E . |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRKCB | up-regulates
phosphorylation
|
EIF4E |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248946 |
Ser209 |
DTATKSGsTTKNRFV |
Mus musculus |
|
| pmid |
sentence |
| 8662663 |
Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins.[..] This suggests a two-step model for the phosphorylation (and activation) of eIF4E by growth factors and hormones: first, dissociation of eIF4E . |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PRKCG |
phosphorylation
|
EIF4E |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248947 |
Ser209 |
DTATKSGsTTKNRFV |
Mus musculus |
|
| pmid |
sentence |
| 8662663 |
Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EIF4E | up-regulates activity
translation regulation
|
MTFP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275429 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 28918902 |
In this study, we demonstrate that mTORC1 stimulates mitochondrial fission via 4E-BP-mediated translational regulation of the mitochondrial fission factor MTFP1. Suppression of mTORC1 activity by pharmacological or genetic means causes mitochondrial hyperfusion, branching, and circularization. This is a consequence of downregulation of MTFP1 levels via the mTORC1/4E-BP pathway, thereby eliciting changes in phosphorylation and localization of the mitochondrial fission factor DRP1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EIF4EBP1 | down-regulates activity
binding
|
EIF4E |
0.938 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167176 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23584478 |
The rate-limiting factor for translation is eukaryotic translation initiation factor 4E (eIF4E), which is negatively regulated by eIF4E-binding protein 1 (4E-BP1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES |
| + |
EIF4E | up-regulates 
|
Protein_synthesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15094766 |
A key player in the regulation of translation is the mRNA 5' cap-binding protein eIF4E, which is the rate-limiting member of the eIF4F complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Insulin Signaling, MTOR Signaling, PI3K/AKT Signaling, SARS-CoV STRESS GRANULES |
| + |
DDX3X | down-regulates activity
binding
|
EIF4E |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269193 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 17667941 |
DDX3 is a human RNA helicase with plethoric functions. we identified translation initiation factor eukaryotic initiation factor 4E (eIF4E) as a DDX3-binding partner. Interestingly, DDX3 utilizes a consensus eIF4E-binding sequence YIPPHLR to interact with the functionally important dorsal surface of eIF4E in a similar manner to other eIF4E-binding proteins. Furthermore, cap affinity chromatography analysis suggests that DDX3 traps eIF4E in a translationally inactive complex by blocking interaction with eIF4G. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269200 |
|
|
Homo sapiens |
HuH-7 Cell |
| pmid |
sentence |
| 17667941 |
DDX3 is a human RNA helicase with plethoric functions. we identified translation initiation factor eukaryotic initiation factor 4E (eIF4E) as a DDX3-binding partner. Interestingly, DDX3 utilizes a consensus eIF4E-binding sequence YIPPHLR to interact with the functionally important dorsal surface of eIF4E in a similar manner to other eIF4E-binding proteins. Furthermore, cap affinity chromatography analysis suggests that DDX3 traps eIF4E in a translationally inactive complex by blocking interaction with eIF4G. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EIF4E | form complex 
binding
|
eIF4F_complex |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11408474 |
Eif4a interacts with a scaffold protein, eif4g, to form complexes that also contain the cap-binding protein eif4e, which binds the cap structure (m7gpppn_) at the 5_-end of the mrna. These complexes are termed eif4f. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PABPC1 | up-regulates activity
binding
|
EIF4E |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260968 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30209168 |
The binding of PABP to mRNA poly(A) tails is followed by interactions with eukaryotic initiation factor (eIF4G) and other translation factors, including eIF4E, to constitute a translation initiation complex, which mediates cellular mRNA circularization and enhances cap-dependent translation by facilitating ribosome recycling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
| + |
EIF4E | up-regulates
|
Translational_regulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268529 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30459806 |
The mRNA cap-binding protein, eukaryotic translation initiation factor 4E (eIF4E), is involved in the recruitment of the ribosome to the mRNA cap structure, playing a central role in the regulation of translation initiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
4E2RCat | down-regulates activity
chemical inhibition
|
EIF4E |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260187 |
|
|
Homo sapiens |
Epithelial Cell |
| pmid |
sentence |
| 21507972 |
Characterization of 4E2RCat, an inhibitor of eIF4E-eIF4G interaction. Herein we describe a molecule from this screen that prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. This inhibitor significantly decreased human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV STRESS GRANULES |
3.0
EIF4E
- 
- 