| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | PFN1 | Ser138 | MASHLRRsQY | phosphorylation down-regulates | 22479341 | SIGNOR-196820 |
| PPP1CA | PFN1 | Ser138 | MASHLRRsQY | dephosphorylation up-regulates | 22479341 | SIGNOR-196816 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ROCK1 | phosphorylation up-regulates → | PFN1 PSer138 | phosphorylation down-regulates ⊣ | PFN1 | 22479341 | SIGNOR-196820 |
| PPP1CA | dephosphorylation down-regulates ⊣ | PFN1 PSer138 | dephosphorylation down-regulates ⊣ | PFN1 | 22479341 | SIGNOR-196816 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ROCK1 | phosphorylation down-regulates | PFN1 | SIGNOR-196820 |
| PPP1CA | dephosphorylation → up-regulates | PFN1 | SIGNOR-196816 |
