Summary

Name PFN1
Full Name Profilin-1
Synonyms Epididymis tissue protein Li 184a, Profilin I
Primary ID P07737
Links - -
Type protein
Relations 5
Function Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation PFN1 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation PFN1 0.249
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png PFN1 0.548
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Actin_cytoskeleton_reorganization 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png CDH4 0.346
Publications: 1 Organism: Homo Sapiens