| Name | RET |
| ID | P07949 |
| Role | kinase |
| Enzymatic Domains |
Cadherin 168-272 PROSITE-ProRule
Protein kinase 724-1016 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | PRKDC | Ser2056 | VQSYSYSsQDPRPAT | phosphorylation up-regulates activity | 26065416 | SIGNOR-279275 |
| RET | RET | Tyr981 | DNCSEEMyRLMLQCW | phosphorylation up-regulates | 14711813 | SIGNOR-121169 |
| RET | ATF4 | – | phosphorylation down-regulates activity | 25795775 | SIGNOR-280103 | |
| RET | ATF4 | Thr107 | LGIDDLEtMPDDLLT | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276448 |
| RET | Gbeta | – | phosphorylation up-regulates | 16153436 | SIGNOR-269894 | |
| RET | MAPK1 | Tyr187 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 16153436 | SIGNOR-140294 |
| RET | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 21454698 | SIGNOR-173013 |
| RET | AKT | – | phosphorylation up-regulates | 12242309 | SIGNOR-244443 | |
| RET | MAPK3 | Tyr204 | HTGFLTEyVATRWYR | phosphorylation up-regulates | 16153436 | SIGNOR-140298 |
| RET | ATF4 | Thr114 | TMPDDLLtTLDDTCD | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276449 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 17126298 | SIGNOR-150875 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 8622669 | SIGNOR-40497 |
| RET | RET | Tyr1029 | TPSDSLIyDDGLSEE | phosphorylation unknown | 8621380 | SIGNOR-248940 |
| RET | STAT1 | Tyr701 | DGPKGTGyIKTELIS | phosphorylation up-regulates activity | 27994058 | SIGNOR-279276 |
| RET | RET | Tyr900 | FGLSRDVyEEDSYVK | phosphorylation up-regulates | 14711813 | SIGNOR-121161 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 17548358 | SIGNOR-155381 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 7535770 | SIGNOR-28059 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 17548358 | SIGNOR-155377 |
| RET | RET | Tyr1096 | RYPNDSVyANWMLSP | phosphorylation up-regulates | 14711813 | SIGNOR-121149 |
| RET | RET | Tyr687 | AQAFPVSySSSGARR | phosphorylation unknown | 8621380 | SIGNOR-248941 |
| RET | RET | Tyr826 | SRKVGPGyLGSGGSR | phosphorylation unknown | 8621380 | SIGNOR-248942 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 7535770 | SIGNOR-28063 |
| RET | AKT | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-166514 |
| RET | RET | Tyr905 | DVYEEDSyVKRSQGR | phosphorylation up-regulates | 14711813 | SIGNOR-121165 |
| RET | RET | Tyr809 | LIVEYAKyGSLRGFL | phosphorylation up-regulates | 14711813 | SIGNOR-121157 |
| RET | MAPK14 | Tyr182 | TDDEMTGyVATRWYR | phosphorylation up-regulates | 17126298 | SIGNOR-150879 |
| RET | PTK2 | Tyr925 | DRSNDKVyENVTGLV | phosphorylation up-regulates | 21454698 | SIGNOR-173021 |
| RET | RET | Tyr1090 | TNTGFPRyPNDSVYA | phosphorylation up-regulates | 14711813 | SIGNOR-121145 |
| RET | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 21454698 | SIGNOR-173017 |
| RET | ATF4 | Thr115 | MPDDLLTtLDDTCDL | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276447 |
| RET | ATF4 | Thr119 | LLTTLDDtCDLFAPL | phosphorylation down-regulates quantity by destabilization | 25795775 | SIGNOR-276450 |
| RET | RET | Tyr1062 | TWIENKLyGMSDPNW | phosphorylation up-regulates | 14711813 | SIGNOR-121141 |
| RET | AKT1 | Tyr315 | TFCGTPEyLAPEVLE | phosphorylation up-regulates | 15994200 | SIGNOR-252619 |
| RET | ERK1/2 | – | phosphorylation up-regulates | 16153436 | SIGNOR-244643 | |
| RET | RET | Tyr900 | FGLSRDVyEEDSYVK | phosphorylation up-regulates | 16928683 | SIGNOR-148992 |
| RET | AFAP1L2 | Tyr54 | SSSSDEEyIYMNKVT | phosphorylation up-regulates activity | 19060924 | SIGNOR-263192 |
| RET | STAT1 | Ser727 | TDNLLPMsPEEFDEV | phosphorylation up-regulates activity | 27994058 | SIGNOR-279277 |
| RET | RET | Tyr806 | PLLLIVEyAKYGSLR | phosphorylation up-regulates | 14711813 | SIGNOR-121153 |
| RET | RET | Tyr1015 | MMVKRRDyLDLAAST | phosphorylation up-regulates | 14981541 | SIGNOR-122915 |
| RET | PDPK1 | Tyr9 | ARTTSQLyDAVPIQS | phosphorylation up-regulates activity | 12738763 | SIGNOR-235863 |
| RET | MAPK14 | Thr180 | RHTDDEMtGYVATRW | phosphorylation up-regulates | 8622669 | SIGNOR-40493 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | phosphorylation up-regulates → | PRKDC PSer2056 | phosphorylation up-regulates → | PRKDC | 26065416 | SIGNOR-279275 |
| RET | phosphorylation up-regulates → | RET PTyr981 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121169 |
| RET | phosphorylation up-regulates → | ATF4 PThr107 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276448 |
| RET | phosphorylation up-regulates → | MAPK1 PTyr187 | phosphorylation up-regulates → | MAPK1 | 16153436 | SIGNOR-140294 |
| RET | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173013 |
| RET | phosphorylation up-regulates → | MAPK3 PTyr204 | phosphorylation up-regulates → | MAPK3 | 16153436 | SIGNOR-140298 |
| RET | phosphorylation up-regulates → | ATF4 PThr114 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276449 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 17126298 | SIGNOR-150875 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40497 |
| RET | phosphorylation up-regulates → | RET PTyr1029 | phosphorylation down-regulates ⊣ | RET | 8621380 | SIGNOR-248940 |
| RET | phosphorylation up-regulates → | STAT1 PTyr701 | phosphorylation up-regulates → | STAT1 | 27994058 | SIGNOR-279276 |
| RET | phosphorylation up-regulates → | RET PTyr900 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121161 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 17548358 | SIGNOR-155381 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-28059 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 17548358 | SIGNOR-155377 |
| RET | phosphorylation up-regulates → | RET PTyr1096 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121149 |
| RET | phosphorylation up-regulates → | RET PTyr687 | phosphorylation down-regulates ⊣ | RET | 8621380 | SIGNOR-248941 |
| RET | phosphorylation up-regulates → | RET PTyr826 | phosphorylation down-regulates ⊣ | RET | 8621380 | SIGNOR-248942 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 7535770 | SIGNOR-28063 |
| RET | phosphorylation up-regulates → | AKT PTyr315 | phosphorylation up-regulates → | AKT | 15994200 | SIGNOR-166514 |
| RET | phosphorylation up-regulates → | RET PTyr905 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121165 |
| RET | phosphorylation up-regulates → | RET PTyr809 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121157 |
| RET | phosphorylation up-regulates → | MAPK14 PTyr182 | phosphorylation up-regulates → | MAPK14 | 17126298 | SIGNOR-150879 |
| RET | phosphorylation up-regulates → | PTK2 PTyr925 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173021 |
| RET | phosphorylation up-regulates → | RET PTyr1090 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121145 |
| RET | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 21454698 | SIGNOR-173017 |
| RET | phosphorylation up-regulates → | ATF4 PThr115 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276447 |
| RET | phosphorylation up-regulates → | ATF4 PThr119 | phosphorylation down-regulates ⊣ | ATF4 | 25795775 | SIGNOR-276450 |
| RET | phosphorylation up-regulates → | RET PTyr1062 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121141 |
| RET | phosphorylation up-regulates → | AKT1 PTyr315 | phosphorylation up-regulates → | AKT1 | 15994200 | SIGNOR-252619 |
| RET | phosphorylation up-regulates → | RET PTyr900 | phosphorylation up-regulates → | RET | 16928683 | SIGNOR-148992 |
| RET | phosphorylation up-regulates → | AFAP1L2 PTyr54 | phosphorylation up-regulates → | AFAP1L2 | 19060924 | SIGNOR-263192 |
| RET | phosphorylation up-regulates → | STAT1 PSer727 | phosphorylation up-regulates → | STAT1 | 27994058 | SIGNOR-279277 |
| RET | phosphorylation up-regulates → | RET PTyr806 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121153 |
| RET | phosphorylation up-regulates → | RET PTyr1015 | phosphorylation up-regulates → | RET | 14981541 | SIGNOR-122915 |
| RET | phosphorylation up-regulates → | PDPK1 PTyr9 | phosphorylation up-regulates → | PDPK1 | 12738763 | SIGNOR-235863 |
| RET | phosphorylation up-regulates → | MAPK14 PThr180 | phosphorylation up-regulates → | MAPK14 | 8622669 | SIGNOR-40493 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RET | phosphorylation → up-regulates activity | PRKDC | SIGNOR-279275 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121169 |
| RET | phosphorylation → down-regulates activity | ATF4 | SIGNOR-280103 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276448 |
| RET | phosphorylation → up-regulates | Gbeta | SIGNOR-269894 |
| RET | phosphorylation → up-regulates | MAPK1 | SIGNOR-140294 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173013 |
| RET | phosphorylation → up-regulates | AKT | SIGNOR-244443 |
| RET | phosphorylation → up-regulates | MAPK3 | SIGNOR-140298 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276449 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-150875 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-40497 |
| RET | phosphorylation → unknown | RET | SIGNOR-248940 |
| RET | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279276 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121161 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-155381 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-28059 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-155377 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121149 |
| RET | phosphorylation → unknown | RET | SIGNOR-248941 |
| RET | phosphorylation → unknown | RET | SIGNOR-248942 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-28063 |
| RET | phosphorylation → up-regulates | AKT | SIGNOR-166514 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121165 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121157 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-150879 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173021 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121145 |
| RET | phosphorylation → up-regulates | PTK2 | SIGNOR-173017 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276447 |
| RET | phosphorylation down-regulates quantity by destabilization | ATF4 | SIGNOR-276450 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121141 |
| RET | phosphorylation → up-regulates | AKT1 | SIGNOR-252619 |
| RET | phosphorylation → up-regulates | ERK1/2 | SIGNOR-244643 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-148992 |
| RET | phosphorylation → up-regulates activity | AFAP1L2 | SIGNOR-263192 |
| RET | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279277 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121153 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-122915 |
| RET | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-235863 |
| RET | phosphorylation → up-regulates | MAPK14 | SIGNOR-40493 |