Summary

Name RET
Full Name Proto-oncogene tyrosine-protein kinase receptor Ret
Synonyms Cadherin family member 12, Proto-oncogene c-Ret | CDHF12, CDHR16, PTC, RET51
Primary ID P07949
Links - -
Type protein
Relations 64
Pathways Thyroid cancer
Inhibitors motesanib; regorafenib; TG101209; sorafenib tosylate; vandetanib; ponatinib; lapatinib; cabozantinib
Function Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation RET 0.397
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation ATF4 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK14 0.333
Publications: 8 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RET 0.2
Publications: 10 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ img/unknown.png phosphorylation RET 0.2
Publications: 3 Organism: Chlorocebus Aethiops
Pathways:Thyroid cancer
+ down-regulates activity img/direct_inhibition.png dephosphorylation RET 0.278
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RET 0.278
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RET 0.427
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK1 0.425
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAPK3 0.435
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AKT 0.323
Publications: 2 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation AKT1 0.323
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AFAP1L2 0.331
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.637
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PDPK1 0.2
Publications: 1 Organism: Cricetulus Griseus
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png phosphorylation RET 0.637
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB10 0.541
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DOK5 0.622
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation Gbeta 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DOK4 0.574
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRB7 0.569
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GFRA1 0.754
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SHC1 0.655
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ up-regulates img/direct-activation.png binding RET 0.714
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DOK6 0.646
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates activity img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation ERK1/2 0.435
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid cancer
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RET 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding DOK1 0.612
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RET 0.91
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition RET 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FRS2 0.677
Publications: 1 Organism: Homo Sapiens