| Name | RET |
| ID | P07949 |
| Role | substrate |
| Enzymatic Domains |
Cadherin 168-272 PROSITE-ProRule
Protein kinase 724-1016 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | RET | Tyr806 | PLLLIVEyAKYGSLR | phosphorylation up-regulates | 14711813 | SIGNOR-121153 |
| RET | RET | Tyr1062 | TWIENKLyGMSDPNW | phosphorylation up-regulates | 14711813 | SIGNOR-121141 |
| RET | RET | Tyr1015 | MMVKRRDyLDLAAST | phosphorylation up-regulates | 14981541 | SIGNOR-122915 |
| RET | RET | Tyr981 | DNCSEEMyRLMLQCW | phosphorylation up-regulates | 14711813 | SIGNOR-121169 |
| RET | RET | Tyr900 | FGLSRDVyEEDSYVK | phosphorylation up-regulates | 14711813 | SIGNOR-121161 |
| PTPRJ | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates activity | 16778204 | SIGNOR-248700 |
| PTPRJ | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates | 16778204 | SIGNOR-147161 |
| RET | RET | Tyr1029 | TPSDSLIyDDGLSEE | phosphorylation unknown | 8621380 | SIGNOR-248940 |
| RET | RET | Tyr1096 | RYPNDSVyANWMLSP | phosphorylation up-regulates | 14711813 | SIGNOR-121149 |
| RET | RET | Tyr687 | AQAFPVSySSSGARR | phosphorylation unknown | 8621380 | SIGNOR-248941 |
| RET | RET | Tyr826 | SRKVGPGyLGSGGSR | phosphorylation unknown | 8621380 | SIGNOR-248942 |
| RET | RET | Tyr905 | DVYEEDSyVKRSQGR | phosphorylation up-regulates | 14711813 | SIGNOR-121165 |
| RET | RET | Tyr809 | LIVEYAKyGSLRGFL | phosphorylation up-regulates | 14711813 | SIGNOR-121157 |
| PTPRJ | RET | Tyr905 | DVYEEDSyVKRSQGR | dephosphorylation down-regulates activity | 16778204 | SIGNOR-248701 |
| RET | RET | Tyr1090 | TNTGFPRyPNDSVYA | phosphorylation up-regulates | 14711813 | SIGNOR-121145 |
| PTPRF | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates | 11121408 | SIGNOR-85170 |
| PTK2 | RET | Tyr905 | DVYEEDSyVKRSQGR | phosphorylation up-regulates | 21454698 | SIGNOR-173009 |
| PRKACA | RET | Ser696 | SSGARRPsLDSMENQ | phosphorylation down-regulates | 20682772 | SIGNOR-167349 |
| PTPRJ | RET | Tyr905 | DVYEEDSyVKRSQGR | dephosphorylation down-regulates | 16778204 | SIGNOR-147165 |
| RET | RET | Tyr900 | FGLSRDVyEEDSYVK | phosphorylation up-regulates | 16928683 | SIGNOR-148992 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | phosphorylation up-regulates → | RET PTyr806 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121153 |
| RET | phosphorylation up-regulates → | RET PTyr1062 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121141 |
| RET | phosphorylation up-regulates → | RET PTyr1015 | phosphorylation up-regulates → | RET | 14981541 | SIGNOR-122915 |
| RET | phosphorylation up-regulates → | RET PTyr981 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121169 |
| RET | phosphorylation up-regulates → | RET PTyr900 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121161 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-248700 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-147161 |
| RET | phosphorylation up-regulates → | RET PTyr1029 | phosphorylation down-regulates ⊣ | RET | 8621380 | SIGNOR-248940 |
| RET | phosphorylation up-regulates → | RET PTyr1096 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121149 |
| RET | phosphorylation up-regulates → | RET PTyr687 | phosphorylation down-regulates ⊣ | RET | 8621380 | SIGNOR-248941 |
| RET | phosphorylation up-regulates → | RET PTyr826 | phosphorylation down-regulates ⊣ | RET | 8621380 | SIGNOR-248942 |
| RET | phosphorylation up-regulates → | RET PTyr905 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121165 |
| RET | phosphorylation up-regulates → | RET PTyr809 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121157 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr905 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-248701 |
| RET | phosphorylation up-regulates → | RET PTyr1090 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121145 |
| PTPRF | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 11121408 | SIGNOR-85170 |
| PTK2 | phosphorylation up-regulates → | RET PTyr905 | phosphorylation up-regulates → | RET | 21454698 | SIGNOR-173009 |
| PRKACA | phosphorylation up-regulates → | RET PSer696 | phosphorylation down-regulates ⊣ | RET | 20682772 | SIGNOR-167349 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr905 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-147165 |
| RET | phosphorylation up-regulates → | RET PTyr900 | phosphorylation up-regulates → | RET | 16928683 | SIGNOR-148992 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RET | phosphorylation → up-regulates | RET | SIGNOR-121153 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121141 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-122915 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121169 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121161 |
| PTPRJ | dephosphorylation → down-regulates activity | RET | SIGNOR-248700 |
| PTPRJ | dephosphorylation down-regulates | RET | SIGNOR-147161 |
| RET | phosphorylation → unknown | RET | SIGNOR-248940 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121149 |
| RET | phosphorylation → unknown | RET | SIGNOR-248941 |
| RET | phosphorylation → unknown | RET | SIGNOR-248942 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121165 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121157 |
| PTPRJ | dephosphorylation → down-regulates activity | RET | SIGNOR-248701 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121145 |
| PTPRF | dephosphorylation down-regulates | RET | SIGNOR-85170 |
| PTK2 | phosphorylation → up-regulates | RET | SIGNOR-173009 |
| PRKACA | phosphorylation down-regulates | RET | SIGNOR-167349 |
| PTPRJ | dephosphorylation down-regulates | RET | SIGNOR-147165 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-148992 |