| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates activity | 16778204 | SIGNOR-248700 |
| PTPRJ | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates | 16778204 | SIGNOR-147161 |
| PTPRF | RET | Tyr1062 | TWIENKLyGMSDPNW | dephosphorylation down-regulates | 11121408 | SIGNOR-85170 |
| RET | RET | Tyr1062 | TWIENKLyGMSDPNW | phosphorylation up-regulates | 14711813 | SIGNOR-121141 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-248700 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-147161 |
| PTPRF | dephosphorylation down-regulates ⊣ | RET PTyr1062 | dephosphorylation up-regulates → | RET | 11121408 | SIGNOR-85170 |
| RET | phosphorylation up-regulates → | RET PTyr1062 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121141 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPRJ | dephosphorylation → down-regulates activity | RET | SIGNOR-248700 |
| PTPRJ | dephosphorylation down-regulates | RET | SIGNOR-147161 |
| PTPRF | dephosphorylation down-regulates | RET | SIGNOR-85170 |
| RET | phosphorylation → up-regulates | RET | SIGNOR-121141 |
