| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | RET | Tyr905 | DVYEEDSyVKRSQGR | phosphorylation up-regulates | 14711813 | SIGNOR-121165 |
| PTPRJ | RET | Tyr905 | DVYEEDSyVKRSQGR | dephosphorylation down-regulates activity | 16778204 | SIGNOR-248701 |
| PTK2 | RET | Tyr905 | DVYEEDSyVKRSQGR | phosphorylation up-regulates | 21454698 | SIGNOR-173009 |
| PTPRJ | RET | Tyr905 | DVYEEDSyVKRSQGR | dephosphorylation down-regulates | 16778204 | SIGNOR-147165 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RET | phosphorylation up-regulates → | RET PTyr905 | phosphorylation up-regulates → | RET | 14711813 | SIGNOR-121165 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr905 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-248701 |
| PTK2 | phosphorylation up-regulates → | RET PTyr905 | phosphorylation up-regulates → | RET | 21454698 | SIGNOR-173009 |
| PTPRJ | dephosphorylation down-regulates ⊣ | RET PTyr905 | dephosphorylation up-regulates → | RET | 16778204 | SIGNOR-147165 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RET | phosphorylation → up-regulates | RET | SIGNOR-121165 |
| PTPRJ | dephosphorylation → down-regulates activity | RET | SIGNOR-248701 |
| PTK2 | phosphorylation → up-regulates | RET | SIGNOR-173009 |
| PTPRJ | dephosphorylation down-regulates | RET | SIGNOR-147165 |
