| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 14744793 | SIGNOR-248070 |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 14593115 | SIGNOR-118936 |
| MAPK3 | SP1 | Ser59 | GGQESQPsPLALLAA | phosphorylation up-regulates | 19318349 | SIGNOR-248079 |
| PRKCZ | SP1 | Ser641 | GKVYGKTsHLRAHLR | phosphorylation up-regulates | 16943418 | SIGNOR-149287 |
| PP1 | SP1 | – | dephosphorylation down-regulates activity | 12684058 | SIGNOR-264669 | |
| MAPK3 | SP1 | Thr453 | SGPIIIRtPTVGPNG | phosphorylation up-regulates | 14744793 | SIGNOR-248062 |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 11904305 | SIGNOR-116174 |
| CyclinB/CDK1 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 20150555 | SIGNOR-216940 |
| PRKCZ | SP1 | Thr681 | QRHKRTHtGEKKFAC | phosphorylation up-regulates | 18258854 | SIGNOR-160774 |
| PPP1CA | SP1 | – | dephosphorylation down-regulates activity | 12684058 | SIGNOR-251952 | |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates activity | 14744793 | SIGNOR-249481 |
| CDK1 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 20150555 | SIGNOR-163738 |
| ERK1/2 | SP1 | – | phosphorylation up-regulates activity | 23616010 | SIGNOR-233523 | |
| MAPK1 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 11904305 | SIGNOR-116166 |
| PTEN | SP1 | – | dephosphorylation down-regulates activity | 21603612 | SIGNOR-277119 | |
| MAPK3 | SP1 | Thr453 | SGPIIIRtPTVGPNG | phosphorylation up-regulates activity | 14744793 | SIGNOR-249480 |
| CyclinA2/CDK2 | SP1 | Ser59 | GGQESQPsPLALLAA | phosphorylation up-regulates activity | 11598016 | SIGNOR-248240 |
| MAPK1 | SP1 | Ser59 | GGQESQPsPLALLAA | phosphorylation up-regulates | 19318349 | SIGNOR-248075 |
| MAPK1 | SP1 | Ser59 | GGQESQPsPLALLAA | phosphorylation up-regulates | 11904305 | SIGNOR-116158 |
| MAPK3 | SP1 | Thr453 | SGPIIIRtPTVGPNG | phosphorylation up-regulates | 14593115 | SIGNOR-248066 |
| PPP2CA | SP1 | Ser59 | GGQESQPsPLALLAA | dephosphorylation up-regulates activity | 24382322 | SIGNOR-248223 |
| MAPK8 | SP1 | Thr278 | SVSAATLtPSSQAVT | phosphorylation up-regulates | 19245816 | SIGNOR-184190 |
| PRKCZ | SP1 | Ser641 | GKVYGKTsHLRAHLR | phosphorylation up-regulates | 19464346 | SIGNOR-185741 |
| SGK1 | SP1 | – | phosphorylation up-regulates activity | 28358001 | SIGNOR-279246 | |
| CDK2 | SP1 | Ser59 | GGQESQPsPLALLAA | phosphorylation up-regulates activity | 11598016 | SIGNOR-248232 |
| Gbeta | SP1 | – | phosphorylation up-regulates | 11904305 | SIGNOR-270104 | |
| PRKCZ | SP1 | Ser670 | CGKRFTRsDELQRHK | phosphorylation up-regulates | 18258854 | SIGNOR-160766 |
| MAPK8 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 19245816 | SIGNOR-184194 |
| PRKCZ | SP1 | Thr668 | SYCGKRFtRSDELQR | phosphorylation up-regulates | 18258854 | SIGNOR-160770 |
| MAPK1 | SP1 | Thr453 | SGPIIIRtPTVGPNG | phosphorylation up-regulates | 11904305 | SIGNOR-116162 |
| CSNK2A1 | SP1 | Thr579 | GDGIHDDtAGGEEGE | phosphorylation down-regulates activity | 9153193 | SIGNOR-250954 |
| ATM | SP1 | Ser101 | DLTATQLsQGANGWQ | phosphorylation unknown | 18619531 | SIGNOR-179435 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 14744793 | SIGNOR-248070 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 14593115 | SIGNOR-118936 |
| MAPK3 | phosphorylation up-regulates → | SP1 PSer59 | phosphorylation up-regulates → | SP1 | 19318349 | SIGNOR-248079 |
| PRKCZ | phosphorylation up-regulates → | SP1 PSer641 | phosphorylation up-regulates → | SP1 | 16943418 | SIGNOR-149287 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr453 | phosphorylation up-regulates → | SP1 | 14744793 | SIGNOR-248062 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 11904305 | SIGNOR-116174 |
| CyclinB/CDK1 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 20150555 | SIGNOR-216940 |
| PRKCZ | phosphorylation up-regulates → | SP1 PThr681 | phosphorylation up-regulates → | SP1 | 18258854 | SIGNOR-160774 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 14744793 | SIGNOR-249481 |
| CDK1 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 20150555 | SIGNOR-163738 |
| MAPK1 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 11904305 | SIGNOR-116166 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr453 | phosphorylation up-regulates → | SP1 | 14744793 | SIGNOR-249480 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | SP1 PSer59 | phosphorylation up-regulates → | SP1 | 11598016 | SIGNOR-248240 |
| MAPK1 | phosphorylation up-regulates → | SP1 PSer59 | phosphorylation up-regulates → | SP1 | 19318349 | SIGNOR-248075 |
| MAPK1 | phosphorylation up-regulates → | SP1 PSer59 | phosphorylation up-regulates → | SP1 | 11904305 | SIGNOR-116158 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr453 | phosphorylation up-regulates → | SP1 | 14593115 | SIGNOR-248066 |
| PPP2CA | dephosphorylation down-regulates ⊣ | SP1 PSer59 | dephosphorylation down-regulates ⊣ | SP1 | 24382322 | SIGNOR-248223 |
| MAPK8 | phosphorylation up-regulates → | SP1 PThr278 | phosphorylation up-regulates → | SP1 | 19245816 | SIGNOR-184190 |
| PRKCZ | phosphorylation up-regulates → | SP1 PSer641 | phosphorylation up-regulates → | SP1 | 19464346 | SIGNOR-185741 |
| CDK2 | phosphorylation up-regulates → | SP1 PSer59 | phosphorylation up-regulates → | SP1 | 11598016 | SIGNOR-248232 |
| PRKCZ | phosphorylation up-regulates → | SP1 PSer670 | phosphorylation up-regulates → | SP1 | 18258854 | SIGNOR-160766 |
| MAPK8 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 19245816 | SIGNOR-184194 |
| PRKCZ | phosphorylation up-regulates → | SP1 PThr668 | phosphorylation up-regulates → | SP1 | 18258854 | SIGNOR-160770 |
| MAPK1 | phosphorylation up-regulates → | SP1 PThr453 | phosphorylation up-regulates → | SP1 | 11904305 | SIGNOR-116162 |
| CSNK2A1 | phosphorylation up-regulates → | SP1 PThr579 | phosphorylation down-regulates ⊣ | SP1 | 9153193 | SIGNOR-250954 |
| ATM | phosphorylation up-regulates → | SP1 PSer101 | phosphorylation down-regulates ⊣ | SP1 | 18619531 | SIGNOR-179435 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-248070 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-118936 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-248079 |
| PRKCZ | phosphorylation → up-regulates | SP1 | SIGNOR-149287 |
| PP1 | dephosphorylation → down-regulates activity | SP1 | SIGNOR-264669 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-248062 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-116174 |
| CyclinB/CDK1 | phosphorylation → up-regulates | SP1 | SIGNOR-216940 |
| PRKCZ | phosphorylation → up-regulates | SP1 | SIGNOR-160774 |
| PPP1CA | dephosphorylation → down-regulates activity | SP1 | SIGNOR-251952 |
| MAPK3 | phosphorylation → up-regulates activity | SP1 | SIGNOR-249481 |
| CDK1 | phosphorylation → up-regulates | SP1 | SIGNOR-163738 |
| ERK1/2 | phosphorylation → up-regulates activity | SP1 | SIGNOR-233523 |
| MAPK1 | phosphorylation → up-regulates | SP1 | SIGNOR-116166 |
| PTEN | dephosphorylation → down-regulates activity | SP1 | SIGNOR-277119 |
| MAPK3 | phosphorylation → up-regulates activity | SP1 | SIGNOR-249480 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | SP1 | SIGNOR-248240 |
| MAPK1 | phosphorylation → up-regulates | SP1 | SIGNOR-248075 |
| MAPK1 | phosphorylation → up-regulates | SP1 | SIGNOR-116158 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-248066 |
| PPP2CA | dephosphorylation → up-regulates activity | SP1 | SIGNOR-248223 |
| MAPK8 | phosphorylation → up-regulates | SP1 | SIGNOR-184190 |
| PRKCZ | phosphorylation → up-regulates | SP1 | SIGNOR-185741 |
| SGK1 | phosphorylation → up-regulates activity | SP1 | SIGNOR-279246 |
| CDK2 | phosphorylation → up-regulates activity | SP1 | SIGNOR-248232 |
| Gbeta | phosphorylation → up-regulates | SP1 | SIGNOR-270104 |
| PRKCZ | phosphorylation → up-regulates | SP1 | SIGNOR-160766 |
| MAPK8 | phosphorylation → up-regulates | SP1 | SIGNOR-184194 |
| PRKCZ | phosphorylation → up-regulates | SP1 | SIGNOR-160770 |
| MAPK1 | phosphorylation → up-regulates | SP1 | SIGNOR-116162 |
| CSNK2A1 | phosphorylation → down-regulates activity | SP1 | SIGNOR-250954 |
| ATM | phosphorylation → unknown | SP1 | SIGNOR-179435 |
