Summary

Name SP1
Full Name Transcription factor Sp1
Synonyms SP1_HUMAN | TSFP1
Primary ID P08047
Links - -
Type protein
Relations 84
Pathways miRNA in AML, FLT3 in AML
Function Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SP1 0.24
Publications: 6 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates activity img/direct-activation.png dephosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation SP1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP1 0.23
Publications: 5 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation SP1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.24
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates img/direct-activation.png phosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Smooth Muscle
+ up-regulates activity img/direct-activation.png binding SP1 0.22
Publications: 2 Organism: Homo Sapiens, In Vitro
Pathways:FLT3 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCNN1A 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CRX 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RHO 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SP1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:miRNA in AML
+ up-regulates activity img/direct-activation.png phosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ up-regulates quantity by expression img/direct-activation.png ITGA11 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KRT16 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PON1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLK3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MAOB 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ABCB1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HYAL1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SOD1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC2A1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MET 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ALOX5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation SLC5A8 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UGT1A4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IFITM5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TBXA2R 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CHGA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PDGFC 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GFER 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CBS 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation POR 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC19A3 0.14
Publications: 1 Organism: Drosophila Melanogaster
+ form complex img/form-complex.png binding SP1/STAT3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CD34 0.14
Publications: 1 Organism: Drosophila Melanogaster
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDUFV1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation SP1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:miRNA in AML
+ up-regulates activity img/direct-activation.png binding SP1 0.56
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation SP1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NDUFV2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PHGDH 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC19A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation THBD 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UGCG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation CDKN2B 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP1B1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DHCR24 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ENG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FMR1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ADAM10 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation ID1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML, miRNA in AML
+ down-regulates activity img/indirect_inhibition.png dephosphorylation SP1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC9A3 0.14
Publications: 1 Organism: Drosophila Melanogaster
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LOR 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HGF 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TGFB1 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ATP2C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD151 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP27A1 0.14
Publications: 1 Organism: Homo Sapiens