| + |
ATM |
phosphorylation
|
SP1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-179435 |
Ser101 |
DLTATQLsQGANGWQ |
Homo sapiens |
|
| pmid |
sentence |
| 18619531 |
Thus, phosphorylation of ser-101 on sp1 is a general response to dna damage, dependent on both atm and atr. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates 
phosphorylation
|
SP1 |
0.629 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248075 |
Ser59 |
GGQESQPsPLALLAA |
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 19318349 |
PKCalpha, which was activated in senescent cells by ROS strongly activated Erk1/2, and the SA-pErk1/2 in turn phosphorylated Sp1 on Ser(59). Sp1-enhanced transcription of p21(Sdi1) resulted in regulation of cellular senescence in primary human diploid fibroblast cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116158 |
Ser59 |
GGQESQPsPLALLAA |
Homo sapiens |
|
| pmid |
sentence |
| 11904305 |
Here we show that p42/p44 mapk directly phosphorylates sp1 on threonines 453 and 739 both in vitro and in vivo. Mutation of these sites to alanines decreases by half the mapk-dependent transcriptional activity of sp1. Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate sp1 on serine 59 and regulate cellular senescence via transcription of p21sdi1/cip1/waf1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116162 |
Thr453 |
SGPIIIRtPTVGPNG |
Homo sapiens |
|
| pmid |
sentence |
| 11904305 |
Here we show that p42/p44 mapk directly phosphorylates sp1 on threonines 453 and 739 both in vitro and in vivo. Mutation of these sites to alanines decreases by half the mapk-dependent transcriptional activity of sp1. Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate sp1 on serine 59 and regulate cellular senescence via transcription of p21sdi1/cip1/waf1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116166 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 11904305 |
Here we show that p42/p44 mapk directly phosphorylates sp1 on threonines 453 and 739 both in vitro and in vivo. Mutation of these sites to alanines decreases by half the mapk-dependent transcriptional activity of sp1. Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate sp1 on serine 59 and regulate cellular senescence via transcription of p21sdi1/cip1/waf1. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | up-regulates activity
phosphorylation
|
SP1 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248240 |
Ser59 |
GGQESQPsPLALLAA |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11598016 |
Mutation of Sp1 Ser59 abrogates the cyclin ACDK augmentation of Sp1-dependent transcriptional transactivation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPP2CA | up-regulates activity
dephosphorylation
|
SP1 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248223 |
Ser59 |
GGQESQPsPLALLAA |
Homo sapiens |
|
| pmid |
sentence |
| 24382322 |
These results indicate that the signals from TCDD or OP caused PP2A-mediated dephosphorylation of Sp1 at Ser-59 and induced CYP1A1 transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | up-regulates activity
phosphorylation
|
SP1 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248232 |
Ser59 |
GGQESQPsPLALLAA |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 11598016 |
Mutation of Sp1 Ser59 abrogates the cyclin ACDK augmentation of Sp1-dependent transcriptional transactivation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MAPK3 | up-regulates
phosphorylation
|
SP1 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248079 |
Ser59 |
GGQESQPsPLALLAA |
Homo sapiens |
|
| pmid |
sentence |
| 19318349 |
PKCalpha, which was activated in senescent cells by ROS strongly activated Erk1/2, and the SA-pErk1/2 in turn phosphorylated Sp1 on Ser(59). Sp1-enhanced transcription of p21(Sdi1) resulted in regulation of cellular senescence in primary human diploid fibroblast cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248066 |
Thr453 |
SGPIIIRtPTVGPNG |
Homo sapiens |
|
| pmid |
sentence |
| 14593115 |
We showed that perifosine activates the mitogen-activated protein/extracellular signal-regulated kinase pathway, and this activation promotes the phosphorylation of sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased sp1 binding and enhanced p21(waf1/cip1) transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248062 |
Thr453 |
SGPIIIRtPTVGPNG |
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 14744793 |
We showed that perifosine activates the mitogen-activated protein/extracellular signal-regulated kinase pathway, and this activation promotes the phosphorylation of sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased sp1 binding and enhanced p21(waf1/cip1) transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248070 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 14744793 |
We showed that perifosine activates the mitogen-activated protein/extracellular signal-regulated kinase pathway, and this activation promotes the phosphorylation of sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased sp1 binding and enhanced p21(waf1/cip1) transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118936 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 14593115 |
We showed that perifosine activates the mitogen-activated protein/extracellular signal-regulated kinase pathway, and this activation promotes the phosphorylation of sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased sp1 binding and enhanced p21(waf1/cip1) transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116174 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 11904305 |
Here we show that p42/p44 mapk directly phosphorylates sp1 on threonines 453 and 739 both in vitro and in vivo. sa-perk1/2 activates the transcription factor, sp1, via ser59 phosphorylation downstream of pkc_, leading to transcription of p21sdi1 and resulting in replicative senescence of hdf cells. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
PRKCZ | up-regulates
phosphorylation
|
SP1 |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185741 |
Ser641 |
GKVYGKTsHLRAHLR |
Homo sapiens |
|
| pmid |
sentence |
| 19464346 |
The hdac inhibitor tsa-induced cell-specific phosphatase release from the promoter, which serves as an 'on' mechanism for sp1 phosphorylation by phosphatidylinositol 3-kinase/protein kinase czeta (pi3k/pkczeta) at ser641, leading to p107 repressor derecruitment and lhr transcriptional activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149287 |
Ser641 |
GKVYGKTsHLRAHLR |
Homo sapiens |
|
| pmid |
sentence |
| 16943418 |
The hdac inhibitor tsa-induced cell-specific phosphatase release from the promoter, which serves as an 'on' mechanism for sp1 phosphorylation by phosphatidylinositol 3-kinase/protein kinase czeta (pi3k/pkczeta) at ser641, leading to p107 repressor derecruitment and lhr transcriptional activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160766 |
Ser670 |
CGKRFTRsDELQRHK |
Homo sapiens |
|
| pmid |
sentence |
| 18258854 |
Here we have used a variety of approaches to identify 3 amino acids (thr668, ser670, and thr681) in the zinc finger domain of sp1 that are modified by pkc-zeta angiotensin ii, which activates pkc-? Phosphorylation (at thr410) via the angiotensin ii type 1 receptor, stimulates sp1 phosphorylation and increases sp1 binding to the platelet-derived growth factor-d promoter. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160770 |
Thr668 |
SYCGKRFtRSDELQR |
Homo sapiens |
|
| pmid |
sentence |
| 18258854 |
Here we have used a variety of approaches to identify 3 amino acids (thr668, ser670, and thr681) in the zinc finger domain of sp1 that are modified by pkc-zeta angiotensin ii, which activates pkc-? Phosphorylation (at thr410) via the angiotensin ii type 1 receptor, stimulates sp1 phosphorylation and increases sp1 binding to the platelet-derived growth factor-d promoter. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160774 |
Thr681 |
QRHKRTHtGEKKFAC |
Homo sapiens |
|
| pmid |
sentence |
| 18258854 |
Here we have used a variety of approaches to identify 3 amino acids (thr668, ser670, and thr681) in the zinc finger domain of sp1 that are modified by pkc-zeta angiotensin ii, which activates pkc-? Phosphorylation (at thr410) via the angiotensin ii type 1 receptor, stimulates sp1 phosphorylation and increases sp1 binding to the platelet-derived growth factor-d promoter. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
MAPK8 | up-regulates
phosphorylation
|
SP1 |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184190 |
Thr278 |
SVSAATLtPSSQAVT |
Homo sapiens |
|
| pmid |
sentence |
| 19245816 |
In addition, for mutation of the jnk-1 phosphorylated residues of sp1, namely, sp1(t278/739a) and sp1(t278/739d), the effect of ga on sp1 stability was reversed. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-184194 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 19245816 |
In addition, for mutation of the jnk-1 phosphorylated residues of sp1, namely, sp1(t278/739a) and sp1(t278/739d), the effect of ga on sp1 stability was reversed. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MAPK3 | up-regulates activity
phosphorylation
|
SP1 |
0.638 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249480 |
Thr453 |
SGPIIIRtPTVGPNG |
Homo sapiens |
|
| pmid |
sentence |
| 14744793 |
Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.|this activation promotes the phosphorylation of Sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased Sp1 binding and enhanced p21(waf1/cip1) transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249481 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 14744793 |
Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.|this activation promotes the phosphorylation of Sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased Sp1 binding and enhanced p21(waf1/cip1) transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | down-regulates activity 
phosphorylation
|
SP1 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250954 |
Thr579 |
GDGIHDDtAGGEEGE |
Homo sapiens |
|
| pmid |
sentence |
| 9153193 |
Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity. | Mutation of a consensus CKII site at amino acid 579, within the second zinc finger, eliminates phosphorylation of this site and the CKII-mediated inhibition of Sp1 binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
SP1 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163738 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 20150555 |
Moreover, we showed that sp1 is a novel mitotic substrate of cdk1/cyclin b1 and is phosphorylated by it at thr 739 before the onset of mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| Pathways: | Acute Myeloid Leukemia |
| + |
CyclinB/CDK1 | up-regulates
phosphorylation
|
SP1 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216940 |
Thr739 |
SEGSGTAtPSALITT |
Homo sapiens |
|
| pmid |
sentence |
| 20150555 |
Moreover, we showed that sp1 is a novel mitotic substrate of cdk1/cyclin b1 and is phosphorylated by it at thr 739 before the onset of mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ASNS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268019 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 11867623 |
Sp1 and Sp3 Activate Transcription Driven by the AS Promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTEN | down-regulates activity
dephosphorylation
|
SP1 |
0.432 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277119 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21603612 |
Moreover, PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1 .|PTEN dephosphorylates the Sp1 transcription factor , the phosphorylation status of which directly impacts its ability to bind to some DNA promoter regions , . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
SP1 | up-regulates quantity by expression 
transcriptional regulation
|
RHO |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225385 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15781457 |
Sp4 and Sp1 are activators of the rod opsin promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates
phosphorylation
|
SP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270104 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11904305 |
Here we show that p42/p44 mapk directly phosphorylates sp1 on threonines 453 and 739 both in vitro and in vivo. sa-perk1/2 activates the transcription factor, sp1, via ser59 phosphorylation downstream of pkc_, leading to transcription of p21sdi1 and resulting in replicative senescence of hdf cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ADAM10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255192 |
|
|
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21854868 |
Doxorubixin-evoked β-TrCP up-regulation promoted Sp1 degradation, which subsequently suppressed ADAM10 expression in MCF-7 and MCF-7/Dox cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
GFER |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254450 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 18513187 |
We also confirmed that activation and repression of hHSS transcription induced by Sp1 and HNF4alpha resulted from binding of these factors to these two cis-elements respectively. Overexpression of HNF4alpha led to a dramatic repression of the promoter activity and, in contrast, the activity was markedly elevated by overexpression of Sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SCNN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251950 |
|
|
Homo sapiens |
Lung Epithelial Cell |
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
PDGFC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254272 |
|
|
Rattus norvegicus |
Aortic Smooth Muscle |
| pmid |
sentence |
| 15247255 |
The PDGF family of ligands is comprised of A, B, C, and D chains. Here, we provide the first functional characterization of the PDGF-C promoter. We examined 797 bp of the human PDGF-C promoter and identified several putative recognition elements for Sp1, Ets Egr-1, and Smad.|These findings thus demonstrate that PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK.|Egr-1 and Sp1 specifically bind the PDGF-C promoter |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SLC19A3 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255215 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 15217784 |
In transiently transfected Drosophila SL2 cells, both SP1 and SP3 transactivated the SLC19A3 minimal promoter in a dose-dependent manner and in combination demonstrated an additive stimulatory effect. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
PON1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255212 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 15380450 |
These data suggest that Sp1 acts as a positive regulator of PON1 transcription, and that an interaction between Sp1 and PKC is a key mechanism for the effect of Sp1 on PON1 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
MET |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241490 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9223667 |
Furthermore, in transient cotransfection assays, overexpression of Sp1 and/or Sp3 stimulated HGF promoter activity independently and additively through binding to the Sp1 binding site in the HGF gene promoter region. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ALOX5 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254032 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19781662 |
The 5-LO promoter possesses a unique GC-rich region which contains consensus sequences for the transcription factors Sp1 and Egr-1 (GC-boxes) which are important for basal transcriptional activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
LORICRIN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254538 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 12200429 |
Mutation and DNA-protein analyses show that Sp1, c-Jun, an unidentified regulator, and the co-activator p300/CREB-binding protein up-regulate whereas Sp3, CREB-1/CREMalpha/ATF-1, Jun B, and an AP2-like protein (termed the keratinocyte-specific repressor-1 (KSR-1)) suppress loricrin promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | form complex 
binding
|
SP1/STAT3 |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187790 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19723038 |
Sp1 and stat3 seem to synergistically augment renalase transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
PHGDH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255208 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18378410 |
Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
UGCG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255205 |
|
|
Homo sapiens |
HL-60 Cell |
| pmid |
sentence |
| 15342415 |
the results suggest that transcriptional up-regulation of GCS through DOX-induced activation of Sp1 is one potential mechanism to regulate ceramide increase and apoptosis in HL-60/ADR cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CD151 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255195 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20149781 |
SP1 is required for basal activation and chromatin accessibility of CD151 promoter in liver cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CYP1B1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12801909 |
It was suggested that mutual interaction of XRE2 and XRE3 is important for transcriptional regulation, and that the Sp1 binding to the Sp1-like motif (-824) enhances both the constitutive and inducible transcriptional activities of the human CYP1B1 gene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ID1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255748 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18025157 |
We show that the ID1 and ID2 promoters are activated by PML-RARalpha but, unexpectedly, not by wild-type RARalpha/RXR. Our data support a model in which the PML-RARalpha fusion protein regulates a novel class of target genes by interaction with the Sp1 and NF-Y transcription factors, without directly binding to the DNA, defining a gain-of-function for the oncoprotein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, miRNA in AML |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SOD1 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253899 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8921911 |
Studies using two mutant versions of this promoter, in which the Sp1 and C/EBP-related factor binding sites were deleted, respectively, revealed that Sp1 and C/EBP-related factors activate the transcription of SOD1 gene. the binding of Sp1 to the proximal upstream region of the Cu/Zn SOD might explain the expression of Cu/Zn SOD in a wide variety of cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDX3X | up-regulates activity
binding
|
SP1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269195 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33627125 |
DDX3X enhances transcription by interacting with transcription factors to promote their binding to the promoter of the target gene. The best characterized mechanism is its cooperation with the transcription factor SP1. The downstream genes of DDX3X-SP1-mediated transactivation include P21, KRAS, and MDM2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33627125 |
DDX3X enhances transcription by interacting with transcription factors to promote their binding to the promoter of the target gene. The best characterized mechanism is its cooperation with the transcription factor SP1. The downstream genes of DDX3X-SP1-mediated transactivation include P21, KRAS, and MDM2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PP1 | down-regulates activity
dephosphorylation
|
SP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFYA | up-regulates activity
binding
|
SP1 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
Our results further confirm the important transactivating role for NF-Y for the CBS-1b promoter, via its synergism with Sp1. While differential phosphorylation of Sp1 likely contributes to binding to multiple GC-/GT-boxes in the CBS-1b and promoter activation [16], NF-Y is clearly necessary for a maximal activation response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | down-regulates activity
dephosphorylation
|
SP1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12684058 |
Transcription factors Sp1 and Sp3 activate alpha-ENaC2 transcription through a GC-rich element (Sp1-binding site) in the promoter. Sp1 and Sp3 are essential for alpha-ENaC2 transcription in lung epithelial cells and that dephosphorylation of the Sp transcription factors by PP1 suppresses alpha-ENaC2 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELA | up-regulates
binding
|
SP1 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
Rela (p65) nf-kappab subunit interacts with the zinc finger dna-binding domain of sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
miR-29b | down-regulates quantity by repression 
post transcriptional regulation
|
SP1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256244 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21730352 |
We provide evidence that PU.1 directly controls expression of at least 4 of these miRs (miR-146a, miR-342, miR-338, and miR-155) through temporally dynamic occupation of binding sites within regulatory chromatin regions adjacent to their genomic coding loci. We conclude that PU.1 bound to open chromatin near 4 of its induced miR loci with 2 types of kinetics: (1) permanent (miR-146a, miR-342, and miR-338) and (2) transient (miR-155) during myeloid differentiation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
FMR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15479157 |
we show that Sp1 (specificity protein 1) and Sp3 are also strong positive regulators of FMR1 promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
NDUFV2 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255207 |
|
|
Homo sapiens |
Neuroblastoma Cell |
| pmid |
sentence |
| 17786189 |
Sp1 role in the regulation of complex I subunits, was demonstrated by the ability of the Sp1/DNA binding inhibitor, mithramycin, to inhibit the transcription of NDUFV1 and NDUFV2, in neuroblastoma cells. In addition, Sp1 activated NDUFV2 promoter by binding to its three GC-boxes. Both activation and binding were inhibited by mithramycin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
TINF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271698 |
|
|
|
|
| pmid |
sentence |
| 21731707 |
Transfection of a plasmid carrying the Sp1 transcription factor into Sp-deficient SL2 cells strongly activated TIN2 promoter-driven luciferase reporter expression. |
|
| Publications: |
1 |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CHGA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254273 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12456801 |
Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response protein 1 (Egr-1) to the distal part of the -92/-62 site is also required for gastrin-dependent CgA transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERK1/2 | up-regulates activity
phosphorylation
|
SP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-233523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23616010 |
Erk also undergoes rapid translocation into the nucleus, where it phosphorylates and activates a variety of transcription factor targets, including sp1, e2f, elk-1, and ap1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML |
| + |
SP1 | up-regulates activity
binding
|
CRX |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-225336 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15781457 |
Zinc finger DNA-binding domains of both Sp1 and Sp3 interact with Crx. Sp4 and Sp1 produce much higher levels of transcriptional activation when co-transfected with Crx, they may additionally act by directly increasing the rate of transcriptional initiation by the general transcriptional apparatus through their activation domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CADM1 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268958 |
|
|
|
|
| pmid |
sentence |
| 18794147 |
Treatment with mithramycin A, an inhibitor of Sp1 or Sp3 binding, resulted in reduction of Cadm1 gene expression, therefore suggesting a potential role of Sp1/Sp3 in Cadm1 regulation. |
|
| Publications: |
1 |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CBS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254812 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12427542 |
We previously described essential transactivating roles for specificity protein 1 (Sp1), Sp3, nuclear factor Y (NF-Y), and USF-1 in the regulation of the CBS-1b promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SLC19A1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254064 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 15652157 |
Collectively, these results identify transcriptionally important regions in the hRFC-C minimal promoter that include a GC-box and CCAAT-box, and suggest that cooperative interactions between Sp1 and C/EBP beta are essential for hRFC-C transactivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
PCYT1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266231 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 10744779 |
Sp1 and Sp3 function as transcriptional activators of the Ctpct promoter |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SLC2A1 |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241485 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9148896 |
These data suggest a regulatory model in which MyoD activation during myogenesis causes the down-regulation of Sp1, which contributes to the repression of GLUT1 gene transcription and, therefore, leads to the reduction in GLUT1 expression and glucose transport. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PML-RARalpha | up-regulates activity
binding
|
SP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255749 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 18025157 |
We show that the ID1 and ID2 promoters are activated by PML-RARalpha but, unexpectedly, not by wild-type RARalpha/RXR. Our data support a model in which the PML-RARalpha fusion protein regulates a novel class of target genes by interaction with the Sp1 and NF-Y transcription factors, without directly binding to the DNA, defining a gain-of-function for the oncoprotein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255729 |
|
|
in vitro |
|
| pmid |
sentence |
| 18025157 |
We show that PML-RARα physically interacts with Sp1 in the absence of DNA. In this report, we show that PML-RARα interacts with Sp1 and may interfere with the expression of genes that are not normally regulated by retinoic acid receptors. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
UGT1A4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254076 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 19546240 |
our data indicate that up-regulation of UGT1A4 expression by E(2) is mediated by both ER alpha and Sp1 and is a potential mechanism contributing to the enhanced elimination of lamotrigine in pregnancy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | down-regulates quantity by repression
transcriptional regulation
|
HYAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253879 |
|
|
Homo sapiens |
253J Cell |
| pmid |
sentence |
| 18718911 |
in cells which do not express HYAL-1, we found SP1 binding to the HYAL-1 promoter. Because both SP1 and Egr-1 have two overlapping binding sites within the promoter (Fig. 5), it appears that although SP1 binding to the methylated HYAL-1 promoter turns off transcription, binding of Erg-1 (and also AP-2) to the unmethylated promoter turns on transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
DHCR24 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255200 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22431021 |
activation of Sp1 by oxidative stress is involved in the promotion of expression of DHCR24 by HCV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
TNC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261600 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 15001984 |
Sp1 and Ets1 are potent transactivators of the TN-C promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ABCB1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253872 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10644769 |
these results indicate a role for both NF-Y and Sp1 in the transcriptional activation of the MDR1 gene by genotoxic stress, and indicate that YB-1, if involved, is not sufficient to mediate this activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
|
ITGA11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253350 |
|
|
Homo sapiens |
HT-1080 Cell |
| pmid |
sentence |
| 16300938 |
We speculate that the "mesenchymal signature" of alpha11 integrin gene expression is controlled by the activity of Sp1/Sp3, fibroblast-specific combinations of Ets family members and yet unidentified enhancer-binding transcription factors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
IFITM5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254218 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23530031 |
Regulation of the bone-restricted IFITM-like (Bril) gene transcription by Sp and Gli family members and CpG methylation. Bril transcription is activated by Sp1, Sp3, OSX, and GLI2 and by CpG demethylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
TGFB1 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251740 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 23936544 |
MAPKs have cis-acting regulatory elements in the mouse-TGF promoter region, which respond to various transcription factors, including specificity protein-1 and activating protein 1. Thus, it is possible that apoptotic cell-induced TGF-β mRNA expression is mediated through activation of these transcription factors via MAPK signaling. Xiao et al. reported that all of the MAPK members, including p38/ERK/JNK, are required for apoptotic Jurkat cells up-regulation of TGF-β production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
TBXA2R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254254 |
|
|
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 19747485 |
Collectively, data establish that regulated WT1 followed by sequential Egr1 and Sp1 binding to elements within Prm1 mediate repression and subsequent induction of TPα during differentiation into the megakaryocytic phenotype, shedding significant insights into factors regulating TPα expression therein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
HGF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251739 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9223667 |
Furthermore, in transient cotransfection assays, overexpression of Sp1 and/or Sp3 stimulated HGF promoter activity independently and additively through binding to the Sp1 binding site in the HGF gene promoter region. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
THBD |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22406829 |
In carcinomas the expression of thrombomodulin (TM) is inversely correlated with tumour progression and metastasis. The expression of TM is negatively regulated by NF-?B- and GSK3-?-dependent signalling pathways and positively regulated by retinoic acid and transcription factor Sp1 in PrEC, LNCaP and PC-3 cells, but not in DU-145 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates
binding
|
SP1 |
0.557 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10671503 |
Rela (p65) nf-kappab subunit interacts with the zinc finger dna-binding domain of sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
RNF4 | down-regulates quantity by destabilization
polyubiquitination
|
SP1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272720 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21983342 |
Here, we identified RNF4 as the ubiquitin E3 ligase of Sp1. From in vitro and in vivo experiments, we found that sumoylated Sp1 can recruit RNF4 as a ubiquitin E3 ligase that subjects sumoylated Sp1 to proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYOD1 | down-regulates quantity by repression
transcriptional regulation
|
SP1 |
0.381 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241765 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9148896 |
These data suggest a regulatory model in which MyoD activation during myogenesis causes the down-regulation of Sp1, which contributes to the repression of GLUT1 gene transcription and, therefore, leads to the reduction in GLUT1 expression and glucose transport. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
RLIM |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268980 |
|
|
|
|
| pmid |
sentence |
| 23650532 |
Thus, RLIM is a novel target of p53, and p53 exerts its inhibitory effect on RLIM expression by interfering with Sp1-mediated transcriptional activation on RLIM.|Although p53 does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 to the RLIM promoter. |
|
| Publications: |
1 |
| + |
SMAD2/SMAD4 | up-regulates activity
binding
|
SP1 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256288 |
|
|
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 11013220 |
TGF-β induces the formation and nuclear translocation of a trimeric Smad complex, which in this case is likely to consist of one monomer each of Smad2, Smad3 and Smad4. Smad2 and Smad4 associate directly with Sp1 and co-activate the transcriptional activity of Sp1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
KLK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253664 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 15708372 |
We characterized four Sp1/Sp3 binding sites in the proximal promoter of the PSA gene. In a luciferase assay, these sites contributed to the basal promoter activity in prostate cancer cells. In an electrophoretic mobility shift assay and chromatin immunoprecipitation assay, we confirmed that Sp1 and Sp3 bind to these sites. Overexpression of wild-type Sp1 and Sp3 further upregulated the promoter activity, whereas overexpression of the Sp1 dominant-negative form or addition of mithramycin A significantly reduced the promoter activity and the endogenous mRNA level of PSA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
POR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255213 |
|
|
Rattus norvegicus |
H4-II-E-C3 Cell |
| pmid |
sentence |
| 8660656 |
Regulation of the NADPH-cytochrome P-450 oxidoreductase gene is controlled by both positive and negative regulatory elements, and, of the nine Sp1 consensus sites, the two proximal sites are sufficient to support basal transcription. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
KRT16 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253903 |
|
|
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 12954631 |
these results suggest that Sp1 and AP1 sites in the essential promoter region are critical for EGF response, and Sp1 showed a functional cooperation with c-Jun and coactivators p300/CBP in driving the transcriptional regulation of EGF-induced keratin 16 gene expression. The coactivators p300/CBP could collaborate with Sp1 and c-Jun in the activation of keratin 16 promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SLC5A8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20082847 |
Luciferase reporter assays of deletion mutants of SLC5A8 promoter demonstrated that a 295-bp region is essential for the basal promoter activity of the SLC5A8 gene. Further analysis indicated that the CCAAT boxes and GC boxes were involved in positive regulation of SLC5A8 promoter. Overexpression of two transcription factors, CCAAT/enhancer binding protein beta (C/EBPbeta) and specific transcription factor 1 (Sp1), upregulated the activities of the human SLC5A8 promoter and protein expression, suggesting that both C/EBPbeta and Sp1 transcription factors might have functions in SLC5A8 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CDKN2B |
0.543 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256289 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11013220 |
In this system, the basal transcription level from the p15Ink4B promoter was increased with increasing levels of Sp1, and Sp1 was required for transcriptional induction by Smads. Finally, inactivation of the Sp1 binding sites in the p15Ink4B promoter decreased the basal transcription level and TGF-β responsiveness. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
GP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254159 |
|
|
Homo sapiens |
Megakaryocyte Cell Line |
| pmid |
sentence |
| 12359731 |
Deletion analyses and site-directed mutagenesis identified Sp1(227), GATA(177), and Ets(48) sites as essential for GPVI expression. We show that transcription factors GATA-1, Fli-1, and Sp1 can bind to and activate this promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
GGH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261350 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31739835 |
Overexpression of Sp1 led to enhanced GGH promoter activity and GGH mRNA expression in allele-specific manners. These findings suggested that Sp1 acted as a positive regulator of human GGH transcription through the rs3758149 polymorphism in CEM/C1 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ENG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255201 |
|
|
Homo sapiens |
Hepatic Stellate Cell |
| pmid |
sentence |
| 21146604 |
In hepatic stellate cells, TGF-β1 upregulates endoglin expression most likely via the ALK5 pathway and requires the SP1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CD34 |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241481 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 10989198 |
Activation of the CD34 promoter by Sp1 requires the presence of a binding domain at -48 bp as well as the 5' untranslated region, which also binds Sp1 |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
MAOB |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253868 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11259630 |
Cotransfection experiments show that Sp1 and its closely related family member Sp4 can trans-activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member BTEB2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SLC9A3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254270 |
|
|
Drosophila melanogaster |
SCHNEIDER-2 Cell |
| pmid |
sentence |
| 16464174 |
Co-transfection of Sp1 or Sp3 into SL2 cells activated the NHE3-reporter constructs, suggesting that Sp1 and Sp3 act as positive regulators of the NHE3 expression. In addition, overexpression of EGR-1 was sufficient to transactivate the NHE3-reporter gene activity |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CACNA1G |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264034 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23868804 |
Consistent with this, Sp1 over-expression enhanced promoter activity while siRNA-mediated Sp1 silencing significantly decreased the level of CaV 3.1 protein and reduced the amplitude of whole-cell T-type Ca(2+) currents expressed in the N1E-115 cells. These results provide new insights into the molecular mechanisms that control CaV 3.1 channel expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
ATP2C1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255194 |
|
|
Homo sapiens |
Keratinocyte |
| pmid |
sentence |
| 15955096 |
when Sp1 or YY1 was overexpressed in keratinocytes, an obvious increase in ATP2C1 promoter activity was observed, which was in contrast with the case where a mutant promoter lacking the binding sites for Sp1 and YY1 was used as the reporter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
NDUFV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255206 |
|
|
Homo sapiens |
Neuroblastoma Cell |
| pmid |
sentence |
| 17786189 |
Sp1 role in the regulation of complex I subunits, was demonstrated by the ability of the Sp1/DNA binding inhibitor, mithramycin, to inhibit the transcription of NDUFV1 and NDUFV2, in neuroblastoma cells. In addition, Sp1 activated NDUFV2 promoter by binding to its three GC-boxes. Both activation and binding were inhibited by mithramycin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
CYP27A1 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255199 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11867220 |
Therefore, Sp1, Sp3 and HNF4 co-operate in the expression of the human CYP27 gene in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
SOD2 |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271693 |
|
|
|
|
| pmid |
sentence |
| 10669635 |
These results suggest that PMA stimulates transcription of the Mn-SOD gene through an increase in Sp1 expression and thus implicate Sp1 as an effector mediating the PKC-signaling pathway elicited by extracellular signals. |
|
| Publications: |
1 |
| + |
TFAP4 | up-regulates activity
binding
|
SP1 |
0.365 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226593 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 19505873 |
We also observed moderately increased recruitment of CTCF, HDAC1, and SP1 by the full-length AP-4 onto the WT DNA beads. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
SP1
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