| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 19245816 | SIGNOR-184194 |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 14744793 | SIGNOR-248070 |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 14593115 | SIGNOR-118936 |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 11904305 | SIGNOR-116174 |
| CyclinB/CDK1 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 20150555 | SIGNOR-216940 |
| MAPK1 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 11904305 | SIGNOR-116166 |
| MAPK3 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates activity | 14744793 | SIGNOR-249481 |
| CDK1 | SP1 | Thr739 | SEGSGTAtPSALITT | phosphorylation up-regulates | 20150555 | SIGNOR-163738 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 19245816 | SIGNOR-184194 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 14744793 | SIGNOR-248070 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 14593115 | SIGNOR-118936 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 11904305 | SIGNOR-116174 |
| CyclinB/CDK1 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 20150555 | SIGNOR-216940 |
| MAPK1 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 11904305 | SIGNOR-116166 |
| MAPK3 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 14744793 | SIGNOR-249481 |
| CDK1 | phosphorylation up-regulates → | SP1 PThr739 | phosphorylation up-regulates → | SP1 | 20150555 | SIGNOR-163738 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation → up-regulates | SP1 | SIGNOR-184194 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-248070 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-118936 |
| MAPK3 | phosphorylation → up-regulates | SP1 | SIGNOR-116174 |
| CyclinB/CDK1 | phosphorylation → up-regulates | SP1 | SIGNOR-216940 |
| MAPK1 | phosphorylation → up-regulates | SP1 | SIGNOR-116166 |
| MAPK3 | phosphorylation → up-regulates activity | SP1 | SIGNOR-249481 |
| CDK1 | phosphorylation → up-regulates | SP1 | SIGNOR-163738 |
