Entity Details

Name	MAPK3_Ser59
ID	P08047
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CyclinA2/CDK2	SP1	Ser59	GGQESQPsPLALLAA	phosphorylation up-regulates activity	11598016	SIGNOR-248240
MAPK1	SP1	Ser59	GGQESQPsPLALLAA	phosphorylation up-regulates	19318349	SIGNOR-248075
MAPK1	SP1	Ser59	GGQESQPsPLALLAA	phosphorylation up-regulates	11904305	SIGNOR-116158
CDK2	SP1	Ser59	GGQESQPsPLALLAA	phosphorylation up-regulates activity	11598016	SIGNOR-248232
PPP2CA	SP1	Ser59	GGQESQPsPLALLAA	dephosphorylation up-regulates activity	24382322	SIGNOR-248223
MAPK3	SP1	Ser59	GGQESQPsPLALLAA	phosphorylation up-regulates	19318349	SIGNOR-248079

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinA2/CDK2	phosphorylation up-regulates →	SP1 PSer59	phosphorylation up-regulates →	SP1	11598016	SIGNOR-248240
MAPK1	phosphorylation up-regulates →	SP1 PSer59	phosphorylation up-regulates →	SP1	19318349	SIGNOR-248075
MAPK1	phosphorylation up-regulates →	SP1 PSer59	phosphorylation up-regulates →	SP1	11904305	SIGNOR-116158
CDK2	phosphorylation up-regulates →	SP1 PSer59	phosphorylation up-regulates →	SP1	11598016	SIGNOR-248232
PPP2CA	dephosphorylation down-regulates ⊣	SP1 PSer59	dephosphorylation down-regulates ⊣	SP1	24382322	SIGNOR-248223
MAPK3	phosphorylation up-regulates →	SP1 PSer59	phosphorylation up-regulates →	SP1	19318349	SIGNOR-248079

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CyclinA2/CDK2	phosphorylation → up-regulates activity	SP1	SIGNOR-248240
MAPK1	phosphorylation → up-regulates	SP1	SIGNOR-248075
MAPK1	phosphorylation → up-regulates	SP1	SIGNOR-116158
CDK2	phosphorylation → up-regulates activity	SP1	SIGNOR-248232
PPP2CA	dephosphorylation → up-regulates activity	SP1	SIGNOR-248223
MAPK3	phosphorylation → up-regulates	SP1	SIGNOR-248079