| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | GLI1 | – | phosphorylation down-regulates | 16293631 | SIGNOR-253539 | |
| MAPK1 | GLI1 | Ser102 | LQTVIRTsPSSLVAF | phosphorylation up-regulates activity | 35831023 | SIGNOR-277601 |
| AMPK | GLI1 | Thr1074 | QRGSSGHtPPPSGPP | phosphorylation down-regulates quantity by destabilization | 26190112 | SIGNOR-253543 |
| PRKAA1 | GLI1 | Thr1074 | QRGSSGHtPPPSGPP | phosphorylation down-regulates activity | 26190112 | SIGNOR-259862 |
| PRKAA1 | GLI1 | Ser408 | GPLPRAPsISTVEPK | phosphorylation down-regulates activity | 26190112 | SIGNOR-259863 |
| AMPK | GLI1 | Ser408 | GPLPRAPsISTVEPK | phosphorylation down-regulates quantity by destabilization | 26843621 | SIGNOR-253540 |
| PKA | GLI1 | Thr374 | PGCTKRYtDPSSLRK | phosphorylation down-regulates activity | 16293631 | SIGNOR-276044 |
| RPS6KB1 | GLI1 | Ser84 | LTKKRALsISPLSDA | phosphorylation up-regulates | 22439934 | SIGNOR-196756 |
| MAPK14 | GLI1 | Ser937 | FLGGSQVsPSRAKAP | phosphorylation down-regulates quantity by destabilization | 38307877 | SIGNOR-277916 |
| IKBKB | GLI1 | – | phosphorylation up-regulates activity | 26603838 | SIGNOR-279194 | |
| MAPK14 | GLI1 | Ser941 | S-->A | phosphorylation down-regulates quantity by destabilization | 38307877 | SIGNOR-277917 |
| PRKAA1 | GLI1 | Ser408 | GPLPRAPsISTVEPK | phosphorylation down-regulates activity | 26190112 | SIGNOR-259860 |
| MAPK1 | GLI1 | Ser130 | HLSIGTMsPSLGFPA | phosphorylation up-regulates activity | 35831023 | SIGNOR-277600 |
| PRKCI | GLI1 | – | phosphorylation up-regulates activity | 26343727 | SIGNOR-279262 | |
| HCK | GLI1 | – | phosphorylation up-regulates activity | 26619401 | SIGNOR-279374 | |
| DYRK1A | GLI1 | Ser408 | GPLPRAPsISTVEPK | phosphorylation up-regulates activity | 28735864 | SIGNOR-278930 |
| AMPK | GLI1 | Ser102 | LQTVIRTsPSSLVAF | phosphorylation down-regulates quantity by destabilization | 26190112 | SIGNOR-253542 |
| PRKAA1 | GLI1 | Ser102 | LQTVIRTsPSSLVAF | phosphorylation down-regulates activity | 26190112 | SIGNOR-259861 |
| AMPK | GLI1 | Ser408 | GPLPRAPsISTVEPK | phosphorylation down-regulates quantity by destabilization | 26190112 | SIGNOR-253541 |
| MAPK14 | GLI1 | Ser982 | VVGANRAsHRAAAPP | phosphorylation down-regulates quantity by destabilization | 38307877 | SIGNOR-277917 |
| DYRK1A | GLI1 | – | phosphorylation up-regulates | 12138125 | SIGNOR-90809 | |
| MAPK1 | GLI1 | Ser116 | FINSRCTsPGGSYGH | phosphorylation up-regulates activity | 35831023 | SIGNOR-277602 |
| ULK3 | GLI1 | – | phosphorylation up-regulates activity | 19878745 | SIGNOR-260797 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | GLI1 PSer102 | phosphorylation up-regulates → | GLI1 | 35831023 | SIGNOR-277601 |
| AMPK | phosphorylation up-regulates → | GLI1 PThr1074 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-253543 |
| PRKAA1 | phosphorylation up-regulates → | GLI1 PThr1074 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-259862 |
| PRKAA1 | phosphorylation up-regulates → | GLI1 PSer408 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-259863 |
| AMPK | phosphorylation up-regulates → | GLI1 PSer408 | phosphorylation down-regulates ⊣ | GLI1 | 26843621 | SIGNOR-253540 |
| PKA | phosphorylation up-regulates → | GLI1 PThr374 | phosphorylation down-regulates ⊣ | GLI1 | 16293631 | SIGNOR-276044 |
| RPS6KB1 | phosphorylation up-regulates → | GLI1 PSer84 | phosphorylation up-regulates → | GLI1 | 22439934 | SIGNOR-196756 |
| MAPK14 | phosphorylation up-regulates → | GLI1 PSer937 | phosphorylation down-regulates ⊣ | GLI1 | 38307877 | SIGNOR-277916 |
| MAPK14 | phosphorylation up-regulates → | GLI1 PSer941 | phosphorylation down-regulates ⊣ | GLI1 | 38307877 | SIGNOR-277917 |
| PRKAA1 | phosphorylation up-regulates → | GLI1 PSer408 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-259860 |
| MAPK1 | phosphorylation up-regulates → | GLI1 PSer130 | phosphorylation up-regulates → | GLI1 | 35831023 | SIGNOR-277600 |
| DYRK1A | phosphorylation up-regulates → | GLI1 PSer408 | phosphorylation up-regulates → | GLI1 | 28735864 | SIGNOR-278930 |
| AMPK | phosphorylation up-regulates → | GLI1 PSer102 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-253542 |
| PRKAA1 | phosphorylation up-regulates → | GLI1 PSer102 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-259861 |
| AMPK | phosphorylation up-regulates → | GLI1 PSer408 | phosphorylation down-regulates ⊣ | GLI1 | 26190112 | SIGNOR-253541 |
| MAPK14 | phosphorylation up-regulates → | GLI1 PSer982 | phosphorylation down-regulates ⊣ | GLI1 | 38307877 | SIGNOR-277917 |
| MAPK1 | phosphorylation up-regulates → | GLI1 PSer116 | phosphorylation up-regulates → | GLI1 | 35831023 | SIGNOR-277602 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation down-regulates | GLI1 | SIGNOR-253539 |
| MAPK1 | phosphorylation → up-regulates activity | GLI1 | SIGNOR-277601 |
| AMPK | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-253543 |
| PRKAA1 | phosphorylation → down-regulates activity | GLI1 | SIGNOR-259862 |
| PRKAA1 | phosphorylation → down-regulates activity | GLI1 | SIGNOR-259863 |
| AMPK | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-253540 |
| PKA | phosphorylation → down-regulates activity | GLI1 | SIGNOR-276044 |
| RPS6KB1 | phosphorylation → up-regulates | GLI1 | SIGNOR-196756 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-277916 |
| IKBKB | phosphorylation → up-regulates activity | GLI1 | SIGNOR-279194 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-277917 |
| PRKAA1 | phosphorylation → down-regulates activity | GLI1 | SIGNOR-259860 |
| MAPK1 | phosphorylation → up-regulates activity | GLI1 | SIGNOR-277600 |
| PRKCI | phosphorylation → up-regulates activity | GLI1 | SIGNOR-279262 |
| HCK | phosphorylation → up-regulates activity | GLI1 | SIGNOR-279374 |
| DYRK1A | phosphorylation → up-regulates activity | GLI1 | SIGNOR-278930 |
| AMPK | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-253542 |
| PRKAA1 | phosphorylation → down-regulates activity | GLI1 | SIGNOR-259861 |
| AMPK | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-253541 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | GLI1 | SIGNOR-277917 |
| DYRK1A | phosphorylation → up-regulates | GLI1 | SIGNOR-90809 |
| MAPK1 | phosphorylation → up-regulates activity | GLI1 | SIGNOR-277602 |
| ULK3 | phosphorylation → up-regulates activity | GLI1 | SIGNOR-260797 |
