| + |
MAPK1 | up-regulates activity 
phosphorylation
|
GLI1 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277601 |
Ser102 |
LQTVIRTsPSSLVAF |
in vitro |
|
| pmid |
sentence |
| 35831023 |
We conclude that multisite phosphorylation of GLI1 by ERK2 or other MAP kinases weakens GLI1-SUFU binding, thereby facilitating GLI1 activation and contributing to both physiological and pathological crosstalk. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277602 |
Ser116 |
FINSRCTsPGGSYGH |
in vitro |
|
| pmid |
sentence |
| 35831023 |
We conclude that multisite phosphorylation of GLI1 by ERK2 or other MAP kinases weakens GLI1-SUFU binding, thereby facilitating GLI1 activation and contributing to both physiological and pathological crosstalk. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277600 |
Ser130 |
HLSIGTMsPSLGFPA |
in vitro |
|
| pmid |
sentence |
| 35831023 |
We conclude that multisite phosphorylation of GLI1 by ERK2 or other MAP kinases weakens GLI1-SUFU binding, thereby facilitating GLI1 activation and contributing to both physiological and pathological crosstalk. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
AMPK | down-regulates quantity by destabilization 
phosphorylation
|
GLI1 |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253542 |
Ser102 |
LQTVIRTsPSSLVAF |
|
|
| pmid |
sentence |
| 26190112 |
Activation of AMPK reduces GLI1 protein levels and stability, thus blocking Sonic-hedgehog-induced transcriptional activity. AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253541 |
Ser408 |
GPLPRAPsISTVEPK |
|
|
| pmid |
sentence |
| 26190112 |
Activation of AMPK reduces GLI1 protein levels and stability, thus blocking Sonic-hedgehog-induced transcriptional activity. AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253540 |
Ser408 |
GPLPRAPsISTVEPK |
|
|
| pmid |
sentence |
| 26843621 |
Indeed we show that AMPK phosphorylates Gli1 at the unique residue Ser408, which is conserved only in primates but not in other species. Once phosphorylated, Gli1 is targeted for proteasomal degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253543 |
Thr1074 |
QRGSSGHtPPPSGPP |
|
|
| pmid |
sentence |
| 26190112 |
Activation of AMPK reduces GLI1 protein levels and stability, thus blocking Sonic-hedgehog-induced transcriptional activity. AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Publications: |
4 |
| + |
PRKAA1 | down-regulates activity
phosphorylation
|
GLI1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259861 |
Ser102 |
LQTVIRTsPSSLVAF |
Homo sapiens |
|
| pmid |
sentence |
| 26190112 |
AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This in turn leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259863 |
Ser408 |
GPLPRAPsISTVEPK |
Homo sapiens |
|
| pmid |
sentence |
| 26190112 |
AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This in turn leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259860 |
Ser408 |
GPLPRAPsISTVEPK |
Homo sapiens |
|
| pmid |
sentence |
| 26190112 |
AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This in turn leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259862 |
Thr1074 |
QRGSSGHtPPPSGPP |
Homo sapiens |
|
| pmid |
sentence |
| 26190112 |
AMPK phosphorylates GLI1 at serines 102 and 408 and threonine 1074. Mutation of these three sites into alanine prevents phosphorylation by AMPK. This in turn leads to increased GLI1 protein stability, transcriptional activity, and oncogenic potency. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
DYRK1A | up-regulates activity
phosphorylation
|
GLI1 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278930 |
Ser408 |
GPLPRAPsISTVEPK |
Homo sapiens |
|
| pmid |
sentence |
| 28735864 |
Here, we have used an in vitro kinase assay and phospho-peptide mass spectrometry analysis to identify site(s) of direct phosphorylation of GLI1 by DYRK1A and have determined that DYRK1A phosphorylates GLI1 at Ser408 within its nuclear localization sequence.|The kinase DYRK1A (dual-specificity tyrosine phosphorylation regulated kinase 1a) has been shown to activate GLI1 via a phosphorylation event, leading to the translocation of GLI1 from the cytoplasm to the nucleus . |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KB1 | up-regulates
phosphorylation
|
GLI1 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-196756 |
Ser84 |
LTKKRALsISPLSDA |
Homo sapiens |
|
| pmid |
sentence |
| 22439934 |
In this study, we found that an activated mtor/s6k1 pathway promotes gli1 transcriptional activity and oncogenic function through s6k1-mediated gli1 phosphorylation at ser84, which releases gli1 from its endogenous inhibitor, sufu. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
GLI1 |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277916 |
Ser937 |
FLGGSQVsPSRAKAP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 38307877 |
Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277917 |
Ser941 |
S-->A |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 38307877 |
Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277917 |
Ser982 |
VVGANRAsHRAAAPP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 38307877 |
Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Glucocorticoid receptor Signaling |
| + |
PKA | down-regulates activity
phosphorylation
|
GLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276044 |
Thr374 |
PGCTKRYtDPSSLRK |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 16293631 |
Here, we report that activation of PKA retains Gli1 in the cytoplasm.Mutation analysis identifies Thr374 as a major PKA site determining Gli1 protein localization. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
GLI3 | down-regulates quantity by repression 
transcriptional regulation
|
GLI1 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209638 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
The basal expression of Gli1, Ptc1, and Hip1 was positively associated with the loss of Gli3 alleles.These findings implicate Gli3 as a repressor of Hh target gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
PTEN | down-regulates
|
GLI1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157776 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17845852 |
Moreover, suppressors of ras akt function, such as the tumor-suppressor pten, and the attenuation of ras signaling involved in senescence, could be thus viewed as modulators of the gli code |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17157787 |
Moreover, suppressors of ras akt function, such as the tumor-suppressor pten, and the attenuation of ras signaling involved in senescence, could be thus viewed as modulators of the gli code |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ZIC1 | up-regulates 
|
GLI1 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105494 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 11238441 |
Moreover, gli proteins were translocated to cell nuclei by coexpressed zic proteins, and both proteins regulated each others transcriptional activity.In Nih3t3 and 293t cells, both gli1 and gli3 proteins were located predominantly in the cytoplasm (fig. 2, c, d, h, k, l, and p). Coexpression of zic1 resulted in gli1 and gli3 proteins being translocated to the nucleus in varying levels (fig. 2, e and m). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKB | up-regulates activity
phosphorylation
|
GLI1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26603838 |
Active IKKbeta promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma.|Herein, we demonstrate that IKKbeta phosphorylates GLI1 in DLBCL. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCI | up-regulates activity
phosphorylation
|
GLI1 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279262 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26343727 |
Although functioning downstream of SMO, aPKC-\u03b9/\u03bb phosphorylates and activates GLI1, resulting in maximal DNA binding and transcriptional activation [ xref ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HCK | up-regulates activity
phosphorylation
|
GLI1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26619401 |
These results suggest that the interaction between Gli1 and Hck or the phosphorylation of Gli1 by Hck disrupts Sufu-Gli1 interaction.|We showed that tyrosine kinase Hck activates Gli1 and the kinase activity is required for its maximum effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SGK1 | down-regulates
binding
|
GLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251672 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25790864 |
SGK1 is known to inhibit another intrinsic pathway, the Hedgehog pathway, through downregulation of SMO and the GLI transcription factor family |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline | down-regulates
chemical inhibition
|
GLI1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154753 |
|
|
Homo sapiens |
Breast Cancer Cell, Prostate Gland Cancer Cell |
| pmid |
sentence |
| 17494766 |
Gant61 was able to efficiently block gli1 as well as gli2-induced transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI1 | up-regulates quantity by expression
transcriptional regulation
|
GLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209617 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Glucocorticoid receptor Signaling, Sonic Hedgehog |
| + |
CXCL1 | up-regulates
|
GLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
The data suggest that smo is in fact the source of two signals relevant to the activation of gli: one involving g(i) and the other involving events at smo's c-tail independent of g(i). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT2 | up-regulates
|
GLI1 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17845852 |
Ras and akt signaling enhances the nuclear localization of gli1, counteracting its suppression by other modifiers that retain it in the cytoplasm, such as suppressor of fused (sufu). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUMB | down-regulates
binding
|
GLI1 |
0.621 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167841 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20818436 |
The consequent activation of_ itch, together with the recruitment of gli1 through direct binding with_ numb, allows gli1 to enter into the complex, resulting in gli1 ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITCH | down-regulates
ubiquitination
|
GLI1 |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150847 |
|
|
Homo sapiens |
Brain Cancer Cell |
| pmid |
sentence |
| 17115028 |
The consequent activation of_ itch, together with the recruitment of gli1 through direct binding with_ numb, allows gli1 to enter into the complex, resulting in gli1 ubiquitination and degradation. we demonstrate that the hedgehog transcription factor gli1 is targeted by numb for itch-dependent ubiquitination, which suppresses hedgehog signals, thus arresting growth and promoting cell differentiation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20818436 |
The consequent activation of_ itch, together with the recruitment of gli1 through direct binding with_ numb, allows gli1 to enter into the complex, resulting in gli1 ubiquitination and degradation. we demonstrate that the hedgehog transcription factor gli1 is targeted by numb for itch-dependent ubiquitination, which suppresses hedgehog signals, thus arresting growth and promoting cell differentiation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GLI1 | up-regulates quantity by expression
transcriptional regulation
|
HHIP |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209623 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
MTSS1 | up-regulates
binding
|
GLI1 |
0.541 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-130542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15545630 |
Mim is a shh-responsive gene that can potentiate gli transcriptional activity.MIM Appears to regulate target gene expression through its association with the gli complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157650 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17845852 |
Mim is a shh-responsive gene that can potentiate gli transcriptional activity.MIM Appears to regulate target gene expression through its association with the gli complex |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
GLI1 | up-regulates quantity by expression
transcriptional regulation
|
PTCH1 |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209620 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188875 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
Gli activators bind to gaccaccca motif to regulate transcription of gli1, ptch1, ptch2, hhip1, mycn, ccnd1, ccnd2, bcl2, cflar, foxf1, foxl1, prdm1 (blimp1), jag2, grem1, and follistatin |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
NRAS | up-regulates
|
GLI1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17845852 |
Ras and akt signaling enhances the nuclear localization of gli1, counteracting its suppression by other modifiers that retain it in the cytoplasm, such as suppressor of fused (sufu) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI1 | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188869 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
Canonical hh signaling plays an essential role in cell proliferation throught introduction of the genes encoding cyclin d1 and n-myc |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GLI2 | up-regulates quantity by expression
transcriptional regulation
|
GLI1 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209629 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16571352 |
Primary mouse embryonic fibroblasts responded to Shh stimulation with the induction of Hh target genes Gli1, Ptc1, and Hip1.These observations support the previously advanced notion of a functional redundancy or cooperativity between Gli2 and Gli1 in activation of target genes [18] and [43] and indicate a functional cooperation between Gli3 and Gli1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
HDAC1 | up-regulates activity
deacetylation
|
GLI1 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253544 |
|
|
|
|
| pmid |
sentence |
| 20081843 |
Here, we identify a mechanism whereby Hh signalling is regulated, in which acetylation of Gli1 at Lys 518 represents a transcriptional inhibitory switch, while its HDAC1-mediated deacetylation is responsible for transcriptional activation. |
|
| Publications: |
1 |
| + |
BTRC | down-regulates quantity by destabilization
ubiquitination
|
GLI1 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235631 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 16421275 |
Here we show that Gli is rapidly destroyed by the proteasome and that mouse basal cell carcinoma induction correlates with Gli protein accumulation. We identify two independent destruction signals in Gli1, D(N) and D(C), and show that removal of these signals stabilizes Gli1 protein and rapidly accelerates tumor formation in transgenic animals.Levels of _TrCP appeared to be limiting for Gli1 degradation, as increasing the levels of _TrCP protein significantly decreased steady-state levels of Gli1 protein |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
KCTD11 | down-regulates activity
|
GLI1 |
0.352 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249592 |
|
|
|
|
| pmid |
sentence |
| 15249678 |
REN(KCTD11) seems to inhibit medulloblastoma growth by negatively regulating the Hedgehog pathway because it antagonizes the Gli-mediated transactivation of Hedgehog target genes, by affecting Gli1 nuclear transfer, and its growth inhibitory activity is impaired by Gli1 inactivation. |
|
| Publications: |
1 |
| + |
DYRK1A | up-regulates
phosphorylation
|
GLI1 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-90809 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12138125 |
Dyrk1 phosphorylates gli1 on more than one domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI1 | up-regulates
|
Cell_growth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 3563490 |
The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
ZIC1 | up-regulates
relocalization
|
GLI1 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105491 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11238441 |
Co-expression of zic1 resulted in gli1 and gli3 proteins being translocated to the nucleus in varying levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SUFU | down-regulates activity
binding
|
GLI1 |
0.949 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249591 |
|
|
|
|
| pmid |
sentence |
| 15367681 |
Here we characterize structural and functional determinants of Su(fu) required for Gli regulation and show that Su(fu) contains at least two distinct domains: a highly conserved carboxy-terminal region required for binding to the amino-terminal ends of the Gli proteins and a unique amino-terminal domain that binds the carboxy-terminal tail of Gli1. While each domain is capable of binding to different Gli1 regions independently, interactions between Su(fu) and Gli1 at both sites are required for cytoplasmic tethering and repression of Gli1 |
|
| Publications: |
1 |
| Pathways: | Sonic Hedgehog |
| + |
ULK3 | up-regulates activity
phosphorylation
|
GLI1 |
0.671 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260797 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 19878745 |
We show that ULK3 is able to phosphorylate three mammalian GLI proteins in vitro. | Our data suggest that serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GLI1 | up-regulates quantity by expression
transcriptional regulation
|
MYCN |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188872 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KAT2B | down-regulates activity
acetylation
|
GLI1 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269270 |
|
|
|
|
| pmid |
sentence |
| 32917954 |
NR3C1 impaired GLI1 function by dynamically modulating the recruitment of PCAF acetyltransferase |
|
| Publications: |
1 |
| + |
GLI1 | form complex 
binding
|
GLI1/GLI2 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269209 |
|
|
Homo sapiens |
PANC-1 Cell |
| pmid |
sentence |
| 32766732 |
GLI1 and GLI2 were shown to co-immunoprecipitate in PANC1 pancreatic cancer cells and RMS13 rhabdomyosarcoma cells.|Chromatin immunoprecipitation showed that GLI1 and GLI2 occupied the same regions at the BCL2, MYCN and CCND1 promoters. Furthermore, depletion of GLI1 inhibited GLI2 occupancy at these promoters, suggesting that GLI1/GLI2 interaction is required for the recruitment of GLI2 to these sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-338-3p | down-regulates quantity by repression
post transcriptional regulation
|
GLI1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277974 |
|
|
Homo sapiens |
MHCC97-H Cell |
| pmid |
sentence |
| 29069716 |
Transfection of MHCC-97H cells with the miR-338-3p mimic resulted in a significant decrease in Gli1 protein and mRNA expression, transfection with the miR-338-3p inhibitor had the opposite effect. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF7 | up-regulates quantity by stabilization
binding
|
GLI1 |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209608 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19549984 |
Kif7 physically interacted with Gli transcription factors and controlled their proteolysis and stability, and acted both positively and negatively in Hh signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Sonic Hedgehog |
| + |
4-(2,4,5-tripyridin-4-yl-3-thiophenyl)pyridine | down-regulates
chemical inhibition
|
GLI1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188863 |
|
|
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 19860666 |
Gant58 is a gli antagonist that inhibits gli1-induced transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates
phosphorylation
|
GLI1 |
0.55 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253539 |
|
|
|
|
| pmid |
sentence |
| 16293631 |
We report that activation of PKA retains Gli1 in the cytoplasm. Conversely, inhibition of PKA activity promotes nuclear accumulation of Gli1.We provide direct evidence to support that the cAMP/PKA signaling axis regulates Gli1 protein localization primarily through a site at Thr374. .These data suggest that Thr374 is an important PKA site responsible for PKA phosphorylation and for the transcriptional activity of Gli1. |
|
| Publications: |
1 |
| Pathways: | Sonic Hedgehog |
| + |
DCAF7 | down-regulates quantity by repression
transcriptional regulation
|
GLI1 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260634 |
|
|
Homo sapiens |
HEK-293T Cell, SZ-95 Cell |
| pmid |
sentence |
| 16887337 |
HAN11 and mDia1 repressed DYRK1A-dependent GLI1 transcriptional activity. The studies of SZ95 cells suggest that HAN11 reduces GLI1-dependent transcription by decreasing the nuclear pool of GLI1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GLI1
- 
- 