Entity Details

Name PRKAA1_Ser408
ID P08151
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
AMPKGLI1Ser408GPLPRAPsISTVEPKphosphorylation
down-regulates quantity by destabilization		26843621SIGNOR-253540
PRKAA1GLI1Ser408GPLPRAPsISTVEPKphosphorylation
down-regulates activity		26190112SIGNOR-259860
AMPKGLI1Ser408GPLPRAPsISTVEPKphosphorylation
down-regulates quantity by destabilization		26190112SIGNOR-253541
PRKAA1GLI1Ser408GPLPRAPsISTVEPKphosphorylation
down-regulates activity		26190112SIGNOR-259863
DYRK1AGLI1Ser408GPLPRAPsISTVEPKphosphorylation
up-regulates activity		28735864SIGNOR-278930
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
AMPKphosphorylation
up-regulates
→
GLI1
PSer408		phosphorylation
down-regulates
⊣		GLI126843621SIGNOR-253540
PRKAA1phosphorylation
up-regulates
→
GLI1
PSer408		phosphorylation
down-regulates
⊣		GLI126190112SIGNOR-259860
AMPKphosphorylation
up-regulates
→
GLI1
PSer408		phosphorylation
down-regulates
⊣		GLI126190112SIGNOR-253541
PRKAA1phosphorylation
up-regulates
→
GLI1
PSer408		phosphorylation
down-regulates
⊣		GLI126190112SIGNOR-259863
DYRK1Aphosphorylation
up-regulates
→
GLI1
PSer408		phosphorylation
up-regulates
→		GLI128735864SIGNOR-278930
Regulator Mechanism/Effect Target SIGNOR-ID
AMPKphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		GLI1SIGNOR-253540
PRKAA1phosphorylation
→
down-regulates activity 		GLI1SIGNOR-259860
AMPKphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		GLI1SIGNOR-253541
PRKAA1phosphorylation
→
down-regulates activity 		GLI1SIGNOR-259863
DYRK1Aphosphorylation
→
up-regulates activity 		GLI1SIGNOR-278930