| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | PDHA1 | Ser295 | RYHGHSMsDPGVSYR | phosphorylation up-regulates activity | 33022274 | SIGNOR-276840 |
| SRC | PDHA1 | Tyr289 | MELQTYRyHGHSMSD | phosphorylation down-regulates activity | 26848621 | SIGNOR-277204 |
| PDK2 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109559 |
| PDK3 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11486000 | SIGNOR-109647 |
| PDK4 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109621 |
| PDP1 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252055 |
| AMPK | PDHA1 | Ser314 | IQEVRSKsDPIMLLK | phosphorylation up-regulates activity | 33022274 | SIGNOR-277894 |
| PRKAA1 | PDHA1 | Ser295 | RYHGHSMsDPGVSYR | phosphorylation up-regulates activity | 33022274 | SIGNOR-276837 |
| PDK2 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 7782287 | SIGNOR-33137 |
| PDK1 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109547 |
| PDP1 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252056 |
| PDK4 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109617 |
| PDK1 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates activity | 11485553 | SIGNOR-109555 |
| PDK3 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109613 |
| AMPK | PDHA1 | Ser295 | RYHGHSMsDPGVSYR | phosphorylation up-regulates activity | 33022274 | SIGNOR-276835 |
| PDK2 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 7782287 | SIGNOR-33141 |
| PDK3 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109609 |
| PDP2 | PDHA1 | – | dephosphorylation up-regulates activity | 20208177 | SIGNOR-251665 | |
| PDK4 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates | 7782287 | SIGNOR-33197 |
| PDP1 | PDHA1 | – | dephosphorylation up-regulates activity | 20208177 | SIGNOR-251664 | |
| PDK1 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates | 7782287 | SIGNOR-32977 |
| PDK3 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates activity | 11486000 | SIGNOR-109651 |
| AMPK | PDHA1 | Ser314 | IQEVRSKsDPIMLLK | phosphorylation up-regulates activity | 33022274 | SIGNOR-276836 |
| PDK2 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109563 |
| PDK4 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 17474719 | SIGNOR-154656 |
| PDK2 | PDHA1 | Ser232 | NRYGMGTsVERAAAS | phosphorylation down-regulates | 7782287 | SIGNOR-33040 |
| PRKAA1 | PDHA1 | Ser314 | IQEVRSKsDPIMLLK | phosphorylation up-regulates activity | 33022274 | SIGNOR-276839 |
| PDP1 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252054 |
| AMPK | PDHA1 | Ser295 | RYHGHSMsDPGVSYR | phosphorylation up-regulates activity | 33022274 | SIGNOR-277895 |
| PRKAA2 | PDHA1 | Ser314 | IQEVRSKsDPIMLLK | phosphorylation up-regulates activity | 33022274 | SIGNOR-276838 |
| PDK1 | PDHA1 | Ser293 | TYRYHGHsMSDPGVS | phosphorylation down-regulates activity | 11485553 | SIGNOR-109551 |
| PDK2 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 17474719 | SIGNOR-154640 |
| PDK4 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 7782287 | SIGNOR-33201 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | phosphorylation up-regulates → | PDHA1 PSer295 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-276840 |
| SRC | phosphorylation up-regulates → | PDHA1 PTyr289 | phosphorylation down-regulates ⊣ | PDHA1 | 26848621 | SIGNOR-277204 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109559 |
| PDK3 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11486000 | SIGNOR-109647 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109621 |
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer232 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252055 |
| AMPK | phosphorylation up-regulates → | PDHA1 PSer314 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-277894 |
| PRKAA1 | phosphorylation up-regulates → | PDHA1 PSer295 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-276837 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33137 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109547 |
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer300 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252056 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109617 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109555 |
| PDK3 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109613 |
| AMPK | phosphorylation up-regulates → | PDHA1 PSer295 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-276835 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33141 |
| PDK3 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109609 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33197 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-32977 |
| PDK3 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 11486000 | SIGNOR-109651 |
| AMPK | phosphorylation up-regulates → | PDHA1 PSer314 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-276836 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109563 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 17474719 | SIGNOR-154656 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer232 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33040 |
| PRKAA1 | phosphorylation up-regulates → | PDHA1 PSer314 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-276839 |
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer293 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252054 |
| AMPK | phosphorylation up-regulates → | PDHA1 PSer295 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-277895 |
| PRKAA2 | phosphorylation up-regulates → | PDHA1 PSer314 | phosphorylation up-regulates → | PDHA1 | 33022274 | SIGNOR-276838 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer293 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109551 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 17474719 | SIGNOR-154640 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33201 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA2 | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-276840 |
| SRC | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-277204 |
| PDK2 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109559 |
| PDK3 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109647 |
| PDK4 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109621 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252055 |
| AMPK | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-277894 |
| PRKAA1 | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-276837 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33137 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109547 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252056 |
| PDK4 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109617 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109555 |
| PDK3 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109613 |
| AMPK | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-276835 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33141 |
| PDK3 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109609 |
| PDP2 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-251665 |
| PDK4 | phosphorylation down-regulates | PDHA1 | SIGNOR-33197 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-251664 |
| PDK1 | phosphorylation down-regulates | PDHA1 | SIGNOR-32977 |
| PDK3 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109651 |
| AMPK | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-276836 |
| PDK2 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109563 |
| PDK4 | phosphorylation down-regulates | PDHA1 | SIGNOR-154656 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33040 |
| PRKAA1 | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-276839 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252054 |
| AMPK | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-277895 |
| PRKAA2 | phosphorylation → up-regulates activity | PDHA1 | SIGNOR-276838 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109551 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-154640 |
| PDK4 | phosphorylation down-regulates | PDHA1 | SIGNOR-33201 |
