| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK2 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 17474719 | SIGNOR-154640 |
| PDP1 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | dephosphorylation up-regulates activity | 7782287 | SIGNOR-252056 |
| PDK1 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates activity | 11485553 | SIGNOR-109555 |
| PDK2 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 7782287 | SIGNOR-33141 |
| PDK3 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates activity | 11486000 | SIGNOR-109651 |
| PDK4 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 17474719 | SIGNOR-154656 |
| PDK4 | PDHA1 | Ser300 | SMSDPGVsYRTREEI | phosphorylation down-regulates | 7782287 | SIGNOR-33201 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 17474719 | SIGNOR-154640 |
| PDP1 | dephosphorylation down-regulates ⊣ | PDHA1 PSer300 | dephosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-252056 |
| PDK1 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 11485553 | SIGNOR-109555 |
| PDK2 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33141 |
| PDK3 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 11486000 | SIGNOR-109651 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 17474719 | SIGNOR-154656 |
| PDK4 | phosphorylation up-regulates → | PDHA1 PSer300 | phosphorylation down-regulates ⊣ | PDHA1 | 7782287 | SIGNOR-33201 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-154640 |
| PDP1 | dephosphorylation → up-regulates activity | PDHA1 | SIGNOR-252056 |
| PDK1 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109555 |
| PDK2 | phosphorylation down-regulates | PDHA1 | SIGNOR-33141 |
| PDK3 | phosphorylation → down-regulates activity | PDHA1 | SIGNOR-109651 |
| PDK4 | phosphorylation down-regulates | PDHA1 | SIGNOR-154656 |
| PDK4 | phosphorylation down-regulates | PDHA1 | SIGNOR-33201 |
