| Name | MET |
| ID | P08581 |
| Role | kinase |
| Enzymatic Domains |
Sema 27-515 PROSITE-ProRule
IPT/TIG 1 563-655
IPT/TIG 2 657-739
IPT/TIG 3 742-836
Protein kinase 1078-1345 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MET | MET | Tyr1234 | RDMYDKEyYSVHNKT | phosphorylation up-regulates | 8302603 | SIGNOR-37723 |
| MET | MET | Tyr1235 | DMYDKEYySVHNKTG | phosphorylation up-regulates | 8302603 | SIGNOR-37727 |
| MET | PARP1 | Tyr907 | MVSKSANyCHTSQGD | phosphorylation up-regulates activity | 26779812 | SIGNOR-279470 |
| MET | STAT3 | – | phosphorylation up-regulates activity | 30143645 | SIGNOR-280041 | |
| MET | IQGAP1 | Tyr1510 | LVKLQQTyAALNSKA | phosphorylation up-regulates activity | 33087447 | SIGNOR-277532 |
| MET | GSK3B | Tyr56 | DRPQEVSyTDTKVIG | phosphorylation up-regulates activity | 30711629 | SIGNOR-277428 |
| MET | CAV1 | – | phosphorylation up-regulates activity | 25148256 | SIGNOR-279080 | |
| MET | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 16782899 | SIGNOR-147179 |
| MET | PTK2 | Tyr397 | SVSETDDyAEIIDEE | phosphorylation up-regulates | 16782899 | SIGNOR-147183 |
| MET | PTK2 | Tyr407 | IIDEEDTyTMPSTRD | phosphorylation up-regulates | 16782899 | SIGNOR-147187 |
| MET | PTK2 | Tyr576 | RYMEDSTyYKASKGK | phosphorylation up-regulates | 16782899 | SIGNOR-147191 |
| MET | PTK2 | Tyr577 | YMEDSTYyKASKGKL | phosphorylation up-regulates | 16782899 | SIGNOR-147195 |
| MET | PTK2 | Tyr861 | PIGNQHIyQPVGKPD | phosphorylation up-regulates | 16782899 | SIGNOR-147199 |
| MET | PTK2 | Tyr925 | DRSNDKVyENVTGLV | phosphorylation up-regulates | 16782899 | SIGNOR-147203 |
| MET | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167654 |
| MET | GAB1 | Tyr285 | TEADGELyVFNTPSG | phosphorylation up-regulates activity | 10734310 | SIGNOR-250552 |
| MET | GAB1 | Tyr589 | SHDSEENyVPMNPNL | phosphorylation up-regulates activity | 10734310 | SIGNOR-250288 |
| MET | GAB1 | Tyr627 | KGDKQVEyLDLDLDS | phosphorylation up-regulates activity | 10734310 | SIGNOR-250289 |
| MET | GAB1 | Tyr659 | VADERVDyVVVDQQK | phosphorylation up-regulates activity | 10734310 | SIGNOR-250290 |
| MET | PTK2B | – | phosphorylation up-regulates activity | 22188814 | SIGNOR-280040 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MET | phosphorylation up-regulates → | MET PTyr1234 | phosphorylation up-regulates → | MET | 8302603 | SIGNOR-37723 |
| MET | phosphorylation up-regulates → | MET PTyr1235 | phosphorylation up-regulates → | MET | 8302603 | SIGNOR-37727 |
| MET | phosphorylation up-regulates → | PARP1 PTyr907 | phosphorylation up-regulates → | PARP1 | 26779812 | SIGNOR-279470 |
| MET | phosphorylation up-regulates → | IQGAP1 PTyr1510 | phosphorylation up-regulates → | IQGAP1 | 33087447 | SIGNOR-277532 |
| MET | phosphorylation up-regulates → | GSK3B PTyr56 | phosphorylation up-regulates → | GSK3B | 30711629 | SIGNOR-277428 |
| MET | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147179 |
| MET | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147183 |
| MET | phosphorylation up-regulates → | PTK2 PTyr407 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147187 |
| MET | phosphorylation up-regulates → | PTK2 PTyr576 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147191 |
| MET | phosphorylation up-regulates → | PTK2 PTyr577 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147195 |
| MET | phosphorylation up-regulates → | PTK2 PTyr861 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147199 |
| MET | phosphorylation up-regulates → | PTK2 PTyr925 | phosphorylation up-regulates → | PTK2 | 16782899 | SIGNOR-147203 |
| MET | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167654 |
| MET | phosphorylation up-regulates → | GAB1 PTyr285 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250552 |
| MET | phosphorylation up-regulates → | GAB1 PTyr589 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250288 |
| MET | phosphorylation up-regulates → | GAB1 PTyr627 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250289 |
| MET | phosphorylation up-regulates → | GAB1 PTyr659 | phosphorylation up-regulates → | GAB1 | 10734310 | SIGNOR-250290 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MET | phosphorylation → up-regulates | MET | SIGNOR-37723 |
| MET | phosphorylation → up-regulates | MET | SIGNOR-37727 |
| MET | phosphorylation → up-regulates activity | PARP1 | SIGNOR-279470 |
| MET | phosphorylation → up-regulates activity | STAT3 | SIGNOR-280041 |
| MET | phosphorylation → up-regulates activity | IQGAP1 | SIGNOR-277532 |
| MET | phosphorylation → up-regulates activity | GSK3B | SIGNOR-277428 |
| MET | phosphorylation → up-regulates activity | CAV1 | SIGNOR-279080 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147179 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147183 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147187 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147191 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147195 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147199 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-147203 |
| MET | phosphorylation → up-regulates | PTK2 | SIGNOR-167654 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250552 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250288 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250289 |
| MET | phosphorylation → up-regulates activity | GAB1 | SIGNOR-250290 |
| MET | phosphorylation → up-regulates activity | PTK2B | SIGNOR-280040 |