Summary

Name MET
Full Name Hepatocyte growth factor receptor
Synonyms HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Primary ID P08581
Links - -
Type protein
Relations 63
Pathways Rhabdomyosarcoma
Inhibitors BMS 794833; cabozantinib; LSM-1131; AMG-208; 2-[4-[3-(6-quinolinylmethyl)-5-triazolo[4,5-b]pyrazinyl]-1-pyrazolyl]ethanol; PHA-665752; crizotinib; SGX-523; AMG 458; 6-[difluoro-[6-(1-methyl-4-pyrazolyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline; N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; MK-2461; SU11274; N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide; NVP-BVU972; N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-3-pyridinecarboxamide
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MET 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.08
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.41
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.47
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MET 0.33
Publications: 2 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.47
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.41
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.39
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.28
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MET 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MET 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.42
Publications: 8 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GAB1 0.45
Publications: 4 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RANBP9 0.46
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRAP 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.33
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation MET 0.22
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MET 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates activity img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MET 0.08
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MET 0.22
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding MET 0.57
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MET 0.42
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png relocalization GLMN 0.08
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MET 0.08
Publications: 1 Organism: Homo Sapiens