| Name | MET |
| ID | P08581 |
| Role | substrate |
| Enzymatic Domains |
Sema 27-515 PROSITE-ProRule
IPT/TIG 1 563-655
IPT/TIG 2 657-739
IPT/TIG 3 742-836
Protein kinase 1078-1345 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | MET | Ser985 | PHLDRLVsARSVSPT | phosphorylation down-regulates | 8294430 | SIGNOR-37718 |
| PTPRJ | MET | Tyr1365 | NVKCVAPyPSLLSSE | dephosphorylation down-regulates activity | 12475979 | SIGNOR-248703 |
| PTPN1 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates | 16537444 | SIGNOR-145145 |
| PTPRB | MET | Tyr1356 | YVHVNATyVNVKCVA | dephosphorylation down-regulates | 21454675 | SIGNOR-173004 |
| PTPN1 | MET | – | dephosphorylation down-regulates activity | 29920310 | SIGNOR-277001 | |
| PTPRB | MET | Tyr1356 | YVHVNATyVNVKCVA | dephosphorylation down-regulates | 16101282 | SIGNOR-139560 |
| PTPRG | MET | Tyr1003 | VSNESVDyRATFPED | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254712 |
| PTPN1 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248412 |
| PTPN2 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248387 |
| PTPRJ | MET | Tyr1365 | NVKCVAPyPSLLSSE | dephosphorylation down-regulates | 12475979 | SIGNOR-96347 |
| PTPN2 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248388 |
| MET | MET | Tyr1235 | DMYDKEYySVHNKTG | phosphorylation up-regulates | 8302603 | SIGNOR-37727 |
| PTPN2 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates | 18819921 | SIGNOR-181335 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 18819921 | SIGNOR-181323 |
| PTPN2 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 18819921 | SIGNOR-181331 |
| PTPRB | MET | Tyr1356 | YVHVNATyVNVKCVA | dephosphorylation down-regulates activity | 21454675 | SIGNOR-248440 |
| PTPN1 | MET | Tyr1235 | DMYDKEYySVHNKTG | dephosphorylation down-regulates | 18819921 | SIGNOR-181327 |
| MET | MET | Tyr1234 | RDMYDKEyYSVHNKT | phosphorylation up-regulates | 8302603 | SIGNOR-37723 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248411 |
| PTPRJ | MET | Tyr1349 | STFIGEHyVHVNATY | dephosphorylation down-regulates activity | 12475979 | SIGNOR-248702 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 16537444 | SIGNOR-145141 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | MET PSer985 | phosphorylation down-regulates ⊣ | MET | 8294430 | SIGNOR-37718 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MET PTyr1365 | dephosphorylation up-regulates → | MET | 12475979 | SIGNOR-248703 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 16537444 | SIGNOR-145145 |
| PTPRB | dephosphorylation down-regulates ⊣ | MET PTyr1356 | dephosphorylation up-regulates → | MET | 21454675 | SIGNOR-173004 |
| PTPRB | dephosphorylation down-regulates ⊣ | MET PTyr1356 | dephosphorylation up-regulates → | MET | 16101282 | SIGNOR-139560 |
| PTPRG | dephosphorylation down-regulates ⊣ | MET PTyr1003 | dephosphorylation up-regulates → | MET | 25624455 | SIGNOR-254712 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248412 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248387 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MET PTyr1365 | dephosphorylation up-regulates → | MET | 12475979 | SIGNOR-96347 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248388 |
| MET | phosphorylation up-regulates → | MET PTyr1235 | phosphorylation up-regulates → | MET | 8302603 | SIGNOR-37727 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181335 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181323 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181331 |
| PTPRB | dephosphorylation down-regulates ⊣ | MET PTyr1356 | dephosphorylation up-regulates → | MET | 21454675 | SIGNOR-248440 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1235 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181327 |
| MET | phosphorylation up-regulates → | MET PTyr1234 | phosphorylation up-regulates → | MET | 8302603 | SIGNOR-37723 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248411 |
| PTPRJ | dephosphorylation down-regulates ⊣ | MET PTyr1349 | dephosphorylation up-regulates → | MET | 12475979 | SIGNOR-248702 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 16537444 | SIGNOR-145141 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | MET | SIGNOR-37718 |
| PTPRJ | dephosphorylation → down-regulates activity | MET | SIGNOR-248703 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-145145 |
| PTPRB | dephosphorylation down-regulates | MET | SIGNOR-173004 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-277001 |
| PTPRB | dephosphorylation down-regulates | MET | SIGNOR-139560 |
| PTPRG | dephosphorylation → down-regulates activity | MET | SIGNOR-254712 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-248412 |
| PTPN2 | dephosphorylation → down-regulates activity | MET | SIGNOR-248387 |
| PTPRJ | dephosphorylation down-regulates | MET | SIGNOR-96347 |
| PTPN2 | dephosphorylation → down-regulates activity | MET | SIGNOR-248388 |
| MET | phosphorylation → up-regulates | MET | SIGNOR-37727 |
| PTPN2 | dephosphorylation down-regulates | MET | SIGNOR-181335 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-181323 |
| PTPN2 | dephosphorylation down-regulates | MET | SIGNOR-181331 |
| PTPRB | dephosphorylation → down-regulates activity | MET | SIGNOR-248440 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-181327 |
| MET | phosphorylation → up-regulates | MET | SIGNOR-37723 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-248411 |
| PTPRJ | dephosphorylation → down-regulates activity | MET | SIGNOR-248702 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-145141 |