| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 18819921 | SIGNOR-181323 |
| PTPN2 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 18819921 | SIGNOR-181331 |
| MET | MET | Tyr1234 | RDMYDKEyYSVHNKT | phosphorylation up-regulates | 8302603 | SIGNOR-37723 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248411 |
| PTPN1 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates | 16537444 | SIGNOR-145141 |
| PTPN2 | MET | Tyr1234 | RDMYDKEyYSVHNKT | dephosphorylation down-regulates activity | 18819921 | SIGNOR-248387 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181323 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-181331 |
| MET | phosphorylation up-regulates → | MET PTyr1234 | phosphorylation up-regulates → | MET | 8302603 | SIGNOR-37723 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248411 |
| PTPN1 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 16537444 | SIGNOR-145141 |
| PTPN2 | dephosphorylation down-regulates ⊣ | MET PTyr1234 | dephosphorylation up-regulates → | MET | 18819921 | SIGNOR-248387 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-181323 |
| PTPN2 | dephosphorylation down-regulates | MET | SIGNOR-181331 |
| MET | phosphorylation → up-regulates | MET | SIGNOR-37723 |
| PTPN1 | dephosphorylation → down-regulates activity | MET | SIGNOR-248411 |
| PTPN1 | dephosphorylation down-regulates | MET | SIGNOR-145141 |
| PTPN2 | dephosphorylation → down-regulates activity | MET | SIGNOR-248387 |
