| Name | PDGFRB |
| ID | P09619 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 1 33-120
Ig-like C2-type 2 129-210
Ig-like C2-type 3 214-309
Ig-like C2-type 4 331-403
Ig-like C2-type 5 416-524
Protein kinase 600-962 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDGFRB | ABL1 | Tyr226 | KRNKPTVyGVSPNYD | phosphorylation up-regulates activity | 19275932 | SIGNOR-278319 |
| PDGFRB | ABL1 | Tyr393 | RLMTGDTyTAHAGAK | phosphorylation up-regulates activity | 19275932 | SIGNOR-278318 |
| PDGFRB | FYN | Tyr28 | SLNQSSGyRYGTDPT | phosphorylation up-regulates activity | 9425276 | SIGNOR-250253 |
| PDGFRB | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | phosphorylation unknown | 2550144 | SIGNOR-22993 |
| PDGFRB | PDGFRB | Tyr857 | DIMRDSNyISKGSTF | phosphorylation unknown | 2550144 | SIGNOR-22997 |
| PDGFRB | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | phosphorylation up-regulates | 1314164 | SIGNOR-16892 |
| PDGFRB | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | phosphorylation up-regulates | 1396585 | SIGNOR-18575 |
| PDGFRB | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | phosphorylation up-regulates | 1396585 | SIGNOR-18579 |
| PDGFRB | PDGFRB | Tyr763 | DMKGDVKyADIESSN | phosphorylation up-regulates activity | 10391677 | SIGNOR-250258 |
| PDGFRB | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | phosphorylation up-regulates activity | 8195171 | SIGNOR-250257 |
| PDGFRB | PDGFRB | Tyr716 | RPPSAELySNALPVG | phosphorylation up-regulates activity | 8940081 | SIGNOR-250256 |
| PDGFRB | PDGFRB | Tyr775 | SSNYMAPyDNYVPSA | phosphorylation up-regulates activity | 8940081 | SIGNOR-250259 |
| PDGFRB | PDGFRB | Tyr579 | VSSDGHEyIYVDPMQ | phosphorylation up-regulates activity | 9642269 | SIGNOR-250254 |
| PDGFRB | PDGFRB | Tyr581 | SDGHEYIyVDPMQLP | phosphorylation up-regulates activity | 9642269 | SIGNOR-250255 |
| PDGFRB | SRC | Tyr419 | RLIEDNEyTARQGAK | phosphorylation up-regulates activity | 15489898 | SIGNOR-247979 |
| PDGFRB | PLCG1 | – | phosphorylation up-regulates | 7535778 | SIGNOR-28179 | |
| PDGFRB | GRK2 | – | phosphorylation up-regulates activity | 15994317 | SIGNOR-278972 | |
| PDGFRB | SHC1 | – | phosphorylation up-regulates | 8195171 | SIGNOR-36906 | |
| PDGFRB | GRK5 | – | phosphorylation up-regulates activity | 19092051 | SIGNOR-279642 | |
| PDGFRB | ABL2 | Tyr116 | PNLFVALyDFVASGD | phosphorylation up-regulates activity | 34144039 | SIGNOR-277304 |
| PDGFRB | ABL2 | Tyr139 | EKLRVLGyNQNGEWS | phosphorylation up-regulates activity | 34144039 | SIGNOR-277302 |
| PDGFRB | ABL2 | Tyr161 | QGWVPSNyITPVNSL | phosphorylation up-regulates activity | 34144039 | SIGNOR-277306 |
| PDGFRB | ABL2 | Tyr272 | KCNKPTVyGVSPIHD | phosphorylation up-regulates activity | 34144039 | SIGNOR-277305 |
| PDGFRB | ABL2 | Tyr299 | HKLGGGQyGEVYVGV | phosphorylation up-regulates activity | 34144039 | SIGNOR-277301 |
| PDGFRB | ABL2 | Tyr303 | GGQYGEVyVGVWKKY | phosphorylation up-regulates activity | 34144039 | SIGNOR-277303 |
| PDGFRB | ABL2 | Tyr310 | YVGVWKKySLTVAVK | phosphorylation up-regulates activity | 34144039 | SIGNOR-277300 |
| PDGFRB | ABL2 | – | phosphorylation up-regulates activity | 34144039 | SIGNOR-279640 | |
| PDGFRB | GNAI1 | Tyr154 | QLNDSAAyYLNDLDR | phosphorylation up-regulates activity | 33139573 | SIGNOR-277233 |
| PDGFRB | GNAI1 | Tyr155 | LNDSAAYyLNDLDRI | phosphorylation up-regulates activity | 33139573 | SIGNOR-277232 |
| PDGFRB | GNAI1 | Tyr320 | RKDTKEIyTHFTCAT | phosphorylation up-regulates activity | 33139573 | SIGNOR-277234 |
| PDGFRB | PTK2 | Tyr194 | ALEKKSNyEVLEKDV | phosphorylation up-regulates | 20802513 | SIGNOR-167658 |
| PDGFRB | PTK2 | Tyr5 | yLDPNLNH | phosphorylation up-regulates | 20802513 | SIGNOR-167662 |
| PDGFRB | PTPN11 | Tyr542 | SKRKGHEyTNIKYSL | phosphorylation up-regulates activity | 8041791 | SIGNOR-250260 |
| PDGFRB | TNK2 | Tyr635 | PLPPPPAyDDVAQDE | phosphorylation up-regulates activity | 25257795 | SIGNOR-276854 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PDGFRB | phosphorylation up-regulates → | ABL1 PTyr226 | phosphorylation up-regulates → | ABL1 | 19275932 | SIGNOR-278319 |
| PDGFRB | phosphorylation up-regulates → | ABL1 PTyr393 | phosphorylation up-regulates → | ABL1 | 19275932 | SIGNOR-278318 |
| PDGFRB | phosphorylation up-regulates → | FYN PTyr28 | phosphorylation up-regulates → | FYN | 9425276 | SIGNOR-250253 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr751 | phosphorylation down-regulates ⊣ | PDGFRB | 2550144 | SIGNOR-22993 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr857 | phosphorylation down-regulates ⊣ | PDGFRB | 2550144 | SIGNOR-22997 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr771 | phosphorylation up-regulates → | PDGFRB | 1314164 | SIGNOR-16892 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr1009 | phosphorylation up-regulates → | PDGFRB | 1396585 | SIGNOR-18575 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr1021 | phosphorylation up-regulates → | PDGFRB | 1396585 | SIGNOR-18579 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr763 | phosphorylation up-regulates → | PDGFRB | 10391677 | SIGNOR-250258 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr740 | phosphorylation up-regulates → | PDGFRB | 8195171 | SIGNOR-250257 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr716 | phosphorylation up-regulates → | PDGFRB | 8940081 | SIGNOR-250256 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr775 | phosphorylation up-regulates → | PDGFRB | 8940081 | SIGNOR-250259 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr579 | phosphorylation up-regulates → | PDGFRB | 9642269 | SIGNOR-250254 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr581 | phosphorylation up-regulates → | PDGFRB | 9642269 | SIGNOR-250255 |
| PDGFRB | phosphorylation up-regulates → | SRC PTyr419 | phosphorylation up-regulates → | SRC | 15489898 | SIGNOR-247979 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr116 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277304 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr139 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277302 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr161 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277306 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr272 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277305 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr299 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277301 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr303 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277303 |
| PDGFRB | phosphorylation up-regulates → | ABL2 PTyr310 | phosphorylation up-regulates → | ABL2 | 34144039 | SIGNOR-277300 |
| PDGFRB | phosphorylation up-regulates → | GNAI1 PTyr154 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277233 |
| PDGFRB | phosphorylation up-regulates → | GNAI1 PTyr155 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277232 |
| PDGFRB | phosphorylation up-regulates → | GNAI1 PTyr320 | phosphorylation up-regulates → | GNAI1 | 33139573 | SIGNOR-277234 |
| PDGFRB | phosphorylation up-regulates → | PTK2 PTyr194 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167658 |
| PDGFRB | phosphorylation up-regulates → | PTK2 PTyr5 | phosphorylation up-regulates → | PTK2 | 20802513 | SIGNOR-167662 |
| PDGFRB | phosphorylation up-regulates → | PTPN11 PTyr542 | phosphorylation up-regulates → | PTPN11 | 8041791 | SIGNOR-250260 |
| PDGFRB | phosphorylation up-regulates → | TNK2 PTyr635 | phosphorylation up-regulates → | TNK2 | 25257795 | SIGNOR-276854 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PDGFRB | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278319 |
| PDGFRB | phosphorylation → up-regulates activity | ABL1 | SIGNOR-278318 |
| PDGFRB | phosphorylation → up-regulates activity | FYN | SIGNOR-250253 |
| PDGFRB | phosphorylation → unknown | PDGFRB | SIGNOR-22993 |
| PDGFRB | phosphorylation → unknown | PDGFRB | SIGNOR-22997 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-16892 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-18575 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-18579 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250258 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250257 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250256 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250259 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250254 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250255 |
| PDGFRB | phosphorylation → up-regulates activity | SRC | SIGNOR-247979 |
| PDGFRB | phosphorylation → up-regulates | PLCG1 | SIGNOR-28179 |
| PDGFRB | phosphorylation → up-regulates activity | GRK2 | SIGNOR-278972 |
| PDGFRB | phosphorylation → up-regulates | SHC1 | SIGNOR-36906 |
| PDGFRB | phosphorylation → up-regulates activity | GRK5 | SIGNOR-279642 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277304 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277302 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277306 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277305 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277301 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277303 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-277300 |
| PDGFRB | phosphorylation → up-regulates activity | ABL2 | SIGNOR-279640 |
| PDGFRB | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277233 |
| PDGFRB | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277232 |
| PDGFRB | phosphorylation → up-regulates activity | GNAI1 | SIGNOR-277234 |
| PDGFRB | phosphorylation → up-regulates | PTK2 | SIGNOR-167658 |
| PDGFRB | phosphorylation → up-regulates | PTK2 | SIGNOR-167662 |
| PDGFRB | phosphorylation → up-regulates activity | PTPN11 | SIGNOR-250260 |
| PDGFRB | phosphorylation → up-regulates activity | TNK2 | SIGNOR-276854 |