Summary

Name PDGFRB
Full Name Platelet-derived growth factor receptor beta
Synonyms PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, Platelet-derived growth factor receptor 1, PDGFR-1 | PDGFR, PDGFR1
Primary ID P09619
Links - -
Type protein
Relations 72
Inhibitors sunitinib; MK-2461; pazopanib hydrochloride; Crenolanib; 2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylic acid; imatinib; tandutinib; pazopanib; 5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-3H-pyrrole-3-carboxamide; canertinib; Telatinib; regorafenib; nintedanib; nilotinib; sorafenib tosylate; axitinib; linifanib; masitinib; orantinib
Function Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.677
Publications: 5 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PDGFRB 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PDGFRB 0.677
Publications: 5 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.54
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.559
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTK2 0.533
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FYN 0.557
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SRC 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPN11 0.736
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PDGFRB 0.2
Publications: 6 Organism: Homo Sapiens, In Vitro, Sus Scrofa
+ down-regulates img/direct_inhibition.png phosphorylation PDGFRB 0.504
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.347
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.736
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation PDGFRB 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation PDGFRB 0.317
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PDGFRB 0.504
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding CRK 0.588
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NCK2 0.593
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation SHC1 0.642
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation PLCG1 0.85
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PDGFRB 0.609
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png binding GRB2 0.664
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NCK1 0.618
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RASA1 0.556
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PDGFRB 0.903
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition PDGFRB 0.8
Publications: 1 Organism: Homo Sapiens