| Name | PDGFRB |
| ID | P09619 |
| Role | substrate |
| Enzymatic Domains |
Ig-like C2-type 1 33-120
Ig-like C2-type 2 129-210
Ig-like C2-type 3 214-309
Ig-like C2-type 4 331-403
Ig-like C2-type 5 416-524
Protein kinase 600-962 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | PDGFRB | Ser254 | WTYPRKEsGRLVEPV | phosphorylation down-regulates activity | 35066967 | SIGNOR-277577 |
| PTPN1 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates | 18567737 | SIGNOR-179068 |
| PDGFRB | PDGFRB | Tyr579 | VSSDGHEyIYVDPMQ | phosphorylation up-regulates activity | 9642269 | SIGNOR-250254 |
| PDGFRB | PDGFRB | Tyr716 | RPPSAELySNALPVG | phosphorylation up-regulates activity | 8940081 | SIGNOR-250256 |
| GRK2 | PDGFRB | Ser1104 | PRAEAEDsFL | phosphorylation down-regulates activity | 15271984 | SIGNOR-278379 |
| ABL1 | PDGFRB | Tyr970 | GEGYKKKyQQVDEEF | phosphorylation down-regulates | 19275932 | SIGNOR-184556 |
| PTPN1 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates | 18567737 | SIGNOR-179080 |
| PTPRG | PDGFRB | Tyr716 | RPPSAELySNALPVG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254715 |
| PTPN1 | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248416 |
| PTPN1 | PDGFRB | Tyr716 | RPPSAELySNALPVG | dephosphorylation down-regulates | 18567737 | SIGNOR-179072 |
| PDGFRB | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | phosphorylation up-regulates activity | 8195171 | SIGNOR-250257 |
| PTPN11 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248669 |
| PTPN11 | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248667 |
| PDGFRB | PDGFRB | Tyr775 | SSNYMAPyDNYVPSA | phosphorylation up-regulates activity | 8940081 | SIGNOR-250259 |
| PTPN1 | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248413 |
| PTPN2 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates activity | 14966296 | SIGNOR-248389 |
| PDGFRB | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | phosphorylation up-regulates | 1396585 | SIGNOR-18575 |
| PTPN1 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates | 18567737 | SIGNOR-179076 |
| PTPN1 | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248415 |
| ABL1 | PDGFRB | Tyr970 | GEGYKKKyQQVDEEF | phosphorylation up-regulates activity | 19275932 | SIGNOR-276143 |
| PDGFRB | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | phosphorylation unknown | 2550144 | SIGNOR-22993 |
| PDGFRB | PDGFRB | Tyr771 | ADIESSNyMAPYDNY | phosphorylation up-regulates | 1314164 | SIGNOR-16892 |
| PDGFRB | PDGFRB | Tyr763 | DMKGDVKyADIESSN | phosphorylation up-regulates activity | 10391677 | SIGNOR-250258 |
| PTPN1 | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | dephosphorylation down-regulates | 18567737 | SIGNOR-179064 |
| ACP1 | PDGFRB | Tyr857 | DIMRDSNyISKGSTF | dephosphorylation down-regulates activity | 12149261 | SIGNOR-248452 |
| ABL1 | PDGFRB | Tyr934 | AHASDEIyEIMQKCW | phosphorylation up-regulates activity | 19275932 | SIGNOR-276141 |
| PDGFRB | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | phosphorylation up-regulates | 1396585 | SIGNOR-18579 |
| PTPN2 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 14966296 | SIGNOR-248390 |
| ABL1 | PDGFRB | Tyr686 | IITEYCRyGDLVDYL | phosphorylation up-regulates activity | 19275932 | SIGNOR-276142 |
| ABL1 | PDGFRB | Tyr686 | IITEYCRyGDLVDYL | phosphorylation down-regulates | 19275932 | SIGNOR-184552 |
| PTPN11 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248668 |
| PTPN1 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248417 |
| PRKG2 | PDGFRB | Ser712 | SDKRRPPsAELYSNA | phosphorylation down-regulates activity | 29935031 | SIGNOR-277401 |
| PDGFRB | PDGFRB | Tyr857 | DIMRDSNyISKGSTF | phosphorylation unknown | 2550144 | SIGNOR-22997 |
| ABL2 | PDGFRB | Tyr686 | IITEYCRyGDLVDYL | phosphorylation up-regulates activity | 19275932 | SIGNOR-276140 |
| PTPRJ | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 12062403 | SIGNOR-248704 |
| ABL1 | PDGFRB | Tyr934 | PAHASDEiYEIMQKC | phosphorylation down-regulates activity | 19275932 | SIGNOR-260931 |
| PDGFRB | PDGFRB | Tyr581 | SDGHEYIyVDPMQLP | phosphorylation up-regulates activity | 9642269 | SIGNOR-250255 |
| PTPN1 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248414 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKG2 | phosphorylation up-regulates → | PDGFRB PSer254 | phosphorylation down-regulates ⊣ | PDGFRB | 35066967 | SIGNOR-277577 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179068 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr579 | phosphorylation up-regulates → | PDGFRB | 9642269 | SIGNOR-250254 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr716 | phosphorylation up-regulates → | PDGFRB | 8940081 | SIGNOR-250256 |
| GRK2 | phosphorylation up-regulates → | PDGFRB PSer1104 | phosphorylation down-regulates ⊣ | PDGFRB | 15271984 | SIGNOR-278379 |
| ABL1 | phosphorylation up-regulates → | PDGFRB PTyr970 | phosphorylation down-regulates ⊣ | PDGFRB | 19275932 | SIGNOR-184556 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179080 |
| PTPRG | dephosphorylation down-regulates ⊣ | PDGFRB PTyr716 | dephosphorylation up-regulates → | PDGFRB | 25624455 | SIGNOR-254715 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1009 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248416 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr716 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179072 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr740 | phosphorylation up-regulates → | PDGFRB | 8195171 | SIGNOR-250257 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248669 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr740 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248667 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr775 | phosphorylation up-regulates → | PDGFRB | 8940081 | SIGNOR-250259 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr740 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248413 |
| PTPN2 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 14966296 | SIGNOR-248389 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr1009 | phosphorylation up-regulates → | PDGFRB | 1396585 | SIGNOR-18575 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179076 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr771 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248415 |
| ABL1 | phosphorylation up-regulates → | PDGFRB PTyr970 | phosphorylation up-regulates → | PDGFRB | 19275932 | SIGNOR-276143 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr751 | phosphorylation down-regulates ⊣ | PDGFRB | 2550144 | SIGNOR-22993 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr771 | phosphorylation up-regulates → | PDGFRB | 1314164 | SIGNOR-16892 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr763 | phosphorylation up-regulates → | PDGFRB | 10391677 | SIGNOR-250258 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1009 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179064 |
| ACP1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr857 | dephosphorylation up-regulates → | PDGFRB | 12149261 | SIGNOR-248452 |
| ABL1 | phosphorylation up-regulates → | PDGFRB PTyr934 | phosphorylation up-regulates → | PDGFRB | 19275932 | SIGNOR-276141 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr1021 | phosphorylation up-regulates → | PDGFRB | 1396585 | SIGNOR-18579 |
| PTPN2 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 14966296 | SIGNOR-248390 |
| ABL1 | phosphorylation up-regulates → | PDGFRB PTyr686 | phosphorylation up-regulates → | PDGFRB | 19275932 | SIGNOR-276142 |
| ABL1 | phosphorylation up-regulates → | PDGFRB PTyr686 | phosphorylation down-regulates ⊣ | PDGFRB | 19275932 | SIGNOR-184552 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248668 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248417 |
| PRKG2 | phosphorylation up-regulates → | PDGFRB PSer712 | phosphorylation down-regulates ⊣ | PDGFRB | 29935031 | SIGNOR-277401 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr857 | phosphorylation down-regulates ⊣ | PDGFRB | 2550144 | SIGNOR-22997 |
| ABL2 | phosphorylation up-regulates → | PDGFRB PTyr686 | phosphorylation up-regulates → | PDGFRB | 19275932 | SIGNOR-276140 |
| PTPRJ | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 12062403 | SIGNOR-248704 |
| ABL1 | phosphorylation up-regulates → | PDGFRB PTyr934 | phosphorylation down-regulates ⊣ | PDGFRB | 19275932 | SIGNOR-260931 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr581 | phosphorylation up-regulates → | PDGFRB | 9642269 | SIGNOR-250255 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248414 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKG2 | phosphorylation → down-regulates activity | PDGFRB | SIGNOR-277577 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179068 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250254 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250256 |
| GRK2 | phosphorylation → down-regulates activity | PDGFRB | SIGNOR-278379 |
| ABL1 | phosphorylation down-regulates | PDGFRB | SIGNOR-184556 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179080 |
| PTPRG | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-254715 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248416 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179072 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250257 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248669 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248667 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250259 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248413 |
| PTPN2 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248389 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-18575 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179076 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248415 |
| ABL1 | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-276143 |
| PDGFRB | phosphorylation → unknown | PDGFRB | SIGNOR-22993 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-16892 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250258 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179064 |
| ACP1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248452 |
| ABL1 | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-276141 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-18579 |
| PTPN2 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248390 |
| ABL1 | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-276142 |
| ABL1 | phosphorylation down-regulates | PDGFRB | SIGNOR-184552 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248668 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248417 |
| PRKG2 | phosphorylation → down-regulates activity | PDGFRB | SIGNOR-277401 |
| PDGFRB | phosphorylation → unknown | PDGFRB | SIGNOR-22997 |
| ABL2 | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-276140 |
| PTPRJ | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248704 |
| ABL1 | phosphorylation → down-regulates activity | PDGFRB | SIGNOR-260931 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250255 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248414 |