| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248416 |
| PDGFRB | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | phosphorylation up-regulates | 1396585 | SIGNOR-18575 |
| PTPN1 | PDGFRB | Tyr1009 | LDTSSVLyTAVQPNE | dephosphorylation down-regulates | 18567737 | SIGNOR-179064 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1009 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248416 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr1009 | phosphorylation up-regulates → | PDGFRB | 1396585 | SIGNOR-18575 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1009 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179064 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248416 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-18575 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179064 |
