| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248417 |
| PDGFRB | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | phosphorylation up-regulates | 1396585 | SIGNOR-18579 |
| PTPN1 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates | 18567737 | SIGNOR-179068 |
| PTPN2 | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 14966296 | SIGNOR-248390 |
| PTPRJ | PDGFRB | Tyr1021 | PNEGDNDyIIPLPDP | dephosphorylation down-regulates activity | 12062403 | SIGNOR-248704 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248417 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr1021 | phosphorylation up-regulates → | PDGFRB | 1396585 | SIGNOR-18579 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179068 |
| PTPN2 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 14966296 | SIGNOR-248390 |
| PTPRJ | dephosphorylation down-regulates ⊣ | PDGFRB PTyr1021 | dephosphorylation up-regulates → | PDGFRB | 12062403 | SIGNOR-248704 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248417 |
| PDGFRB | phosphorylation → up-regulates | PDGFRB | SIGNOR-18579 |
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179068 |
| PTPN2 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248390 |
| PTPRJ | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248704 |
