| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248667 |
| PTPN1 | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248413 |
| PDGFRB | PDGFRB | Tyr740 | TGESDGGyMDMSKDE | phosphorylation up-regulates activity | 8195171 | SIGNOR-250257 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr740 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248667 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr740 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248413 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr740 | phosphorylation up-regulates → | PDGFRB | 8195171 | SIGNOR-250257 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248667 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248413 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250257 |
