| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates | 18567737 | SIGNOR-179076 |
| PDGFRB | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | phosphorylation unknown | 2550144 | SIGNOR-22993 |
| PTPN11 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248668 |
| PTPN1 | PDGFRB | Tyr751 | SKDESVDyVPMLDMK | dephosphorylation down-regulates activity | 7545675 | SIGNOR-248414 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179076 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr751 | phosphorylation down-regulates ⊣ | PDGFRB | 2550144 | SIGNOR-22993 |
| PTPN11 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248668 |
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr751 | dephosphorylation up-regulates → | PDGFRB | 7545675 | SIGNOR-248414 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179076 |
| PDGFRB | phosphorylation → unknown | PDGFRB | SIGNOR-22993 |
| PTPN11 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248668 |
| PTPN1 | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-248414 |
