| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | PDGFRB | Tyr716 | RPPSAELySNALPVG | dephosphorylation down-regulates | 18567737 | SIGNOR-179072 |
| PTPRG | PDGFRB | Tyr716 | RPPSAELySNALPVG | dephosphorylation down-regulates activity | 25624455 | SIGNOR-254715 |
| PDGFRB | PDGFRB | Tyr716 | RPPSAELySNALPVG | phosphorylation up-regulates activity | 8940081 | SIGNOR-250256 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates ⊣ | PDGFRB PTyr716 | dephosphorylation up-regulates → | PDGFRB | 18567737 | SIGNOR-179072 |
| PTPRG | dephosphorylation down-regulates ⊣ | PDGFRB PTyr716 | dephosphorylation up-regulates → | PDGFRB | 25624455 | SIGNOR-254715 |
| PDGFRB | phosphorylation up-regulates → | PDGFRB PTyr716 | phosphorylation up-regulates → | PDGFRB | 8940081 | SIGNOR-250256 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation down-regulates | PDGFRB | SIGNOR-179072 |
| PTPRG | dephosphorylation → down-regulates activity | PDGFRB | SIGNOR-254715 |
| PDGFRB | phosphorylation → up-regulates activity | PDGFRB | SIGNOR-250256 |
