| Name | CALM1 |
| ID | P0DP23 |
| Role | substrate |
| Enzymatic Domains |
EF-hand 1 8-43 PROSITE-ProRule
EF-hand 2 44-79 PROSITE-ProRule
EF-hand 3 81-116 PROSITE-ProRule
EF-hand 4 117-149 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | CALM1 | Tyr100 | FDKDGNGyISAAELR | phosphorylation down-regulates | 3415247 | SIGNOR-24778 |
| CSNK2A1 | CALM1 | Ser82 | RKMKDTDsEEEIREA | phosphorylation down-regulates activity | 26675311 | SIGNOR-266353 |
| CSNK2A1 | CALM1 | Thr118 | TNLGEKLtDEEVDEM | phosphorylation down-regulates activity | 26675311 | SIGNOR-266355 |
| CSNK2A1 | CALM1 | Thr80 | MARKMKDtDSEEEIR | phosphorylation down-regulates activity | 26675311 | SIGNOR-266356 |
| EGFR | CALM1 | Tyr100 | FDKDGNGyISAAELR | phosphorylation down-regulates | 7925415 | SIGNOR-34691 |
| INSR | CALM1 | Tyr100 | FDKDGNGyISAAELR | phosphorylation down-regulates | 3415247 | SIGNOR-24782 |
| CSNK2A1 | CALM1 | Ser102 | KDGNGYIsAAELRHV | phosphorylation down-regulates activity | 26675311 | SIGNOR-266354 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EGFR | phosphorylation up-regulates → | CALM1 PTyr100 | phosphorylation down-regulates ⊣ | CALM1 | 3415247 | SIGNOR-24778 |
| CSNK2A1 | phosphorylation up-regulates → | CALM1 PSer82 | phosphorylation down-regulates ⊣ | CALM1 | 26675311 | SIGNOR-266353 |
| CSNK2A1 | phosphorylation up-regulates → | CALM1 PThr118 | phosphorylation down-regulates ⊣ | CALM1 | 26675311 | SIGNOR-266355 |
| CSNK2A1 | phosphorylation up-regulates → | CALM1 PThr80 | phosphorylation down-regulates ⊣ | CALM1 | 26675311 | SIGNOR-266356 |
| EGFR | phosphorylation up-regulates → | CALM1 PTyr100 | phosphorylation down-regulates ⊣ | CALM1 | 7925415 | SIGNOR-34691 |
| INSR | phosphorylation up-regulates → | CALM1 PTyr100 | phosphorylation down-regulates ⊣ | CALM1 | 3415247 | SIGNOR-24782 |
| CSNK2A1 | phosphorylation up-regulates → | CALM1 PSer102 | phosphorylation down-regulates ⊣ | CALM1 | 26675311 | SIGNOR-266354 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EGFR | phosphorylation down-regulates | CALM1 | SIGNOR-24778 |
| CSNK2A1 | phosphorylation → down-regulates activity | CALM1 | SIGNOR-266353 |
| CSNK2A1 | phosphorylation → down-regulates activity | CALM1 | SIGNOR-266355 |
| CSNK2A1 | phosphorylation → down-regulates activity | CALM1 | SIGNOR-266356 |
| EGFR | phosphorylation down-regulates | CALM1 | SIGNOR-34691 |
| INSR | phosphorylation down-regulates | CALM1 | SIGNOR-24782 |
| CSNK2A1 | phosphorylation → down-regulates activity | CALM1 | SIGNOR-266354 |