Summary

Name CALM1
Full Name Calmodulin-1
Synonyms CALM1_HUMAN | CALM, CAM, CAM1
Primary ID P0DP23
Links - -
Type protein
Relations 23
Pathways B-cell activation, Mitochondrial dynamics in T cell exhaustion, Satellite: Calcium&myogenesis, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
Function Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (PubMed:25441029). Acts as a sensor to modulate the endomplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (PubMed:28890335).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation CALM1 0.434
Publications: 4 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation CALM1 0.415
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CALM1 0.413
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP3CC 0.655
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PP2B 0.761
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation CALM1 0.8
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:B-cell activation, T cell activation, Thyroid Hormone Metabolism, VEGF Signaling
+ up-regulates img/direct-activation.png binding CAMKK2 0.826
Publications: 1 Organism: Homo Sapiens
Pathways:Thyroid Hormone Metabolism
+ up-regulates activity img/direct-activation.png binding GEM 0.337
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding CALM1 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NOS3 0.751
Publications: 1 Organism: Homo Sapiens
Pathways:VEGF Signaling
+ up-regulates img/direct-activation.png binding Calcineurin 0.569
Publications: 1 Organism: Homo Sapiens
Pathways:B-cell activation, T cell activation
+ up-regulates activity img/direct-activation.png binding KIF1A 0.279
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding SCN8A 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP3CA 0.75
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png binding EEF2K 0.478
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CAMKK1 0.755
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PPP3CB 0.693
Publications: 1 Organism: Homo Sapiens