| Name | MYBL2 |
| ID | P10244 |
| Role | substrate |
| Enzymatic Domains |
HTH myb-type 1 26-77 PROSITE-ProRule
HTH myb-type 2 78-133 PROSITE-ProRule
HTH myb-type 3 134-184 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | MYBL2 | Ser393 | RGELIPIsPSTEVGG | phosphorylation up-regulates activity | 10593981 | SIGNOR-250734 |
| CDK2 | MYBL2 | Thr494 | TPLHRDKtPLHQKHA | phosphorylation up-regulates | 9840932 | SIGNOR-62365 |
| CDK2 | MYBL2 | Ser577 | RKPGLRRsPIKKVRK | phosphorylation up-regulates | 9840932 | SIGNOR-62353 |
| CDK2 | MYBL2 | Thr405 | VGGSGIGtPPSVLKR | phosphorylation up-regulates activity | 10593981 | SIGNOR-250737 |
| CDK2 | MYBL2 | Thr520 | DNTPHTPtPFKNALE | phosphorylation up-regulates activity | 10593981 | SIGNOR-250741 |
| CDK2 | MYBL2 | Ser452 | PVKTLPFsPSQFLNF | phosphorylation up-regulates activity | 10593981 | SIGNOR-250735 |
| CDK2 | MYBL2 | Thr444 | NSLTPKStPVKTLPF | phosphorylation up-regulates | 9840932 | SIGNOR-62357 |
| CyclinA2/CDK2 | MYBL2 | Thr444 | NSLTPKStPVKTLPF | phosphorylation up-regulates | 9840932 | SIGNOR-217256 |
| CyclinA2/CDK2 | MYBL2 | Ser577 | RKPGLRRsPIKKVRK | phosphorylation up-regulates | 9840932 | SIGNOR-217252 |
| CDK2 | MYBL2 | Thr487 | SQKVVVTtPLHRDKT | phosphorylation up-regulates | 9840932 | SIGNOR-62361 |
| CDK2 | MYBL2 | Thr266 | TDLDAVRtPEPLEEF | phosphorylation up-regulates activity | 10593981 | SIGNOR-250736 |
| CyclinA2/CDK2 | MYBL2 | Thr494 | TPLHRDKtPLHQKHA | phosphorylation up-regulates | 9840932 | SIGNOR-217264 |
| CyclinA2/CDK2 | MYBL2 | Thr487 | SQKVVVTtPLHRDKT | phosphorylation up-regulates | 9840932 | SIGNOR-217260 |
| CDK2 | MYBL2 | Thr515 | QKYSMDNtPHTPTPF | phosphorylation up-regulates activity | 10593981 | SIGNOR-250739 |
| CDK2 | MYBL2 | Thr518 | SMDNTPHtPTPFKNA | phosphorylation up-regulates activity | 10593981 | SIGNOR-250740 |
| CDK2 | MYBL2 | Thr440 | LDSCNSLtPKSTPVK | phosphorylation unknown | 10095772 | SIGNOR-250738 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | MYBL2 PSer393 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250734 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr494 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-62365 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PSer577 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-62353 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr405 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250737 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr520 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250741 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PSer452 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250735 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr444 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-62357 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PThr444 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217256 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PSer577 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217252 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr487 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-62361 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr266 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250736 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PThr494 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217264 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | MYBL2 PThr487 | phosphorylation up-regulates → | MYBL2 | 9840932 | SIGNOR-217260 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr515 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250739 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr518 | phosphorylation up-regulates → | MYBL2 | 10593981 | SIGNOR-250740 |
| CDK2 | phosphorylation up-regulates → | MYBL2 PThr440 | phosphorylation down-regulates ⊣ | MYBL2 | 10095772 | SIGNOR-250738 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250734 |
| CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-62365 |
| CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-62353 |
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250737 |
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250741 |
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250735 |
| CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-62357 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217256 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217252 |
| CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-62361 |
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250736 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217264 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | MYBL2 | SIGNOR-217260 |
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250739 |
| CDK2 | phosphorylation → up-regulates activity | MYBL2 | SIGNOR-250740 |
| CDK2 | phosphorylation → unknown | MYBL2 | SIGNOR-250738 |