| + |
CDK2 | up-regulates activity 
phosphorylation
|
MYBL2 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250734 |
Ser393 |
RGELIPIsPSTEVGG |
|
HEK-293 Cell |
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250735 |
Ser452 |
PVKTLPFsPSQFLNF |
|
HEK-293 Cell |
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250736 |
Thr266 |
TDLDAVRtPEPLEEF |
|
HEK-293 Cell |
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250737 |
Thr405 |
VGGSGIGtPPSVLKR |
|
HEK-293 Cell |
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250739 |
Thr515 |
QKYSMDNtPHTPTPF |
|
HEK-293 Cell |
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250740 |
Thr518 |
SMDNTPHtPTPFKNA |
|
|
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250741 |
Thr520 |
DNTPHTPtPFKNALE |
Homo sapiens |
|
| pmid |
sentence |
| 10593981 |
Ten phosphorylation sites carboxyl-terminal to the DNA-binding domain were identified by this method: threonines at positions 267, 408, 497, 519, 522, and 524 and serines at positions 283, 396, 455, and 581. | Our results indicate that B-Myb can be phosphorylated in a cell-free system by both cyclin A-Cdk2 and cyclin E-Cdk2 complexes. | These data suggest that B-Myb is a target for phosphorylation by cyclin-Cdk2 and that phosphorylation of B-Myb regulates its transcriptional activity. |
|
| Publications: |
7 |
Organism: |
, Homo Sapiens |
| + |
CDK2 | up-regulates
phosphorylation
|
MYBL2 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62353 |
Ser577 |
RKPGLRRsPIKKVRK |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62357 |
Thr444 |
NSLTPKStPVKTLPF |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62361 |
Thr487 |
SQKVVVTtPLHRDKT |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-62365 |
Thr494 |
TPLHRDKtPLHQKHA |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk4 |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CyclinA2/CDK2 | up-regulates
phosphorylation
|
MYBL2 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217252 |
Ser577 |
RKPGLRRsPIKKVRK |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk5 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217256 |
Thr444 |
NSLTPKStPVKTLPF |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk3 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217260 |
Thr487 |
SQKVVVTtPLHRDKT |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217264 |
Thr494 |
TPLHRDKtPLHQKHA |
Homo sapiens |
|
| pmid |
sentence |
| 9840932 |
The cell-cycle regulated transcription factor b-myb is phosphorylated by cyclin a/cdk2 at sites that enhance its transactivation properties. we show that b-myb is phosphorylated at thr447, thr490, thr497 and ser581 by cyclin a/cdk4 |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
CDK2 |
phosphorylation
|
MYBL2 |
0.718 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250738 |
Thr440 |
LDSCNSLtPKSTPVK |
|
HEK-293 Cell |
| pmid |
sentence |
| 10095772 |
In summary, our work has identified several phosphorylation sites for cyclin A/Cdk2 in B-Myb and shown that mutation of at least one of these sites has a strong effect on the inducibility of the B-Myb transactivation potential by cyclin A/Cdk2. |
|
| Publications: |
1 |
| + |
SKP2 | down-regulates quantity by destabilization 
polyubiquitination
|
MYBL2 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272572 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 10871850 |
P19Skp1 and Cul-1 bind to the F-box protein p45Skp2 to form a complex (SCF) that functions as E3 ubiquitin ligase.We show that B-Myb physically and functionally interacts with components of the Cdc34-SCFp45Skp2 ubiquitin pathway and propose that B-Myb degradation may be required for controlling the correct alternation of events during progression through the cell division cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMYM2 | up-regulates activity
binding
|
MYBL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269801 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 32439918 |
Here we have identified the zinc-finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins. B-MYB has been implicated in cell cycle progression at two steps, namely at the G1/S- and the G2/M-transition. ZMYM2 is required for the G1/S-transition in HepG2 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYBL2 | up-regulates quantity by expression
transcriptional regulation
|
CLU |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269800 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10770937 |
Here we show that the human ApoJ/Clusterin gene contains a Myb binding site in its 5' flanking region, which interacts with bacterially synthesized B-MYB protein and mediates B-MYB-dependent transactivation of the ApoJ/Clusterin promoter in transient transfection assays. Endogenous ApoJ/Clusterin expression is induced in mammalian cell lines following transient transfection of a B-MYB cDNA. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
E2F1 | up-regulates quantity by expression 
transcriptional regulation
|
MYBL2 |
0.497 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253855 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 14618416 |
To assess transactivating activity of E2F1/DP-1, we also analyzed expression of ten putative transcriptional targets of this complex in HCCs. Expression levels of TFDP1 and E2F1 correlated with those of seven transcriptional targets ( TYMS, DHFR, PCNA, RRM1, CCNE1, CDC2, and MYBL2) that play important roles in the G1/S transition, and down-regulation of TFDP1 inhibited growth of Hep3B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFDP1 | up-regulates quantity by expression
transcriptional regulation
|
MYBL2 |
0.51 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253862 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 14618416 |
To assess transactivating activity of E2F1/DP-1, we also analyzed expression of ten putative transcriptional targets of this complex in HCCs. Expression levels of TFDP1 and E2F1 correlated with those of seven transcriptional targets ( TYMS, DHFR, PCNA, RRM1, CCNE1, CDC2, and MYBL2) that play important roles in the G1/S transition, and down-regulation of TFDP1 inhibited growth of Hep3B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MYBL2
- 
- 