Entity Details

Name RRAS
ID P10301
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ERK1/2RRASSer201
View in OncoXplorer
QEQELPPsPPSAPRKphosphorylation
up-regulates activity		27086924SIGNOR-277219
ERK1/2RRASSer186S-->Lphosphorylation
up-regulates activity		27086924SIGNOR-277220
SRCRRASTyr66DPTIEDSyTKICSVDphosphorylation
down-regulates activity		11682467SIGNOR-111189
EPHB2RRASTyr66DPTIEDSyTKICSVDphosphorylation
down-regulates activity		10570155SIGNOR-251125
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ERK1/2phosphorylation
up-regulates
→
RRAS
PSer201		phosphorylation
up-regulates
→		RRAS27086924SIGNOR-277219
ERK1/2phosphorylation
up-regulates
→
RRAS
PSer186		phosphorylation
up-regulates
→		RRAS27086924SIGNOR-277220
SRCphosphorylation
up-regulates
→
RRAS
PTyr66		phosphorylation
down-regulates
⊣		RRAS11682467SIGNOR-111189
EPHB2phosphorylation
up-regulates
→
RRAS
PTyr66		phosphorylation
down-regulates
⊣		RRAS10570155SIGNOR-251125
Regulator Mechanism/Effect Target SIGNOR-ID
ERK1/2phosphorylation
→
up-regulates activity 		RRASSIGNOR-277219
ERK1/2phosphorylation
→
up-regulates activity 		RRASSIGNOR-277220
SRCphosphorylation
→
down-regulates activity 		RRASSIGNOR-111189
EPHB2phosphorylation
→
down-regulates activity 		RRASSIGNOR-251125