| + |
SRC | down-regulates activity 
phosphorylation
|
RRAS |
0.56 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111189 |
Tyr66 |
DPTIEDSyTKICSVD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11682467 |
The small gtpase, r-ras, affects cell adhesion by maintaining integrin activity. Activated src oncogene phosphorylates r-ras and suppresses integrin activity. the src phosphorylation site in r-ras was tyrosine 66 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPHB2 | down-regulates activity
phosphorylation
|
RRAS |
0.591 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251125 |
Tyr66 |
DPTIEDSyTKICSVD |
Homo sapiens |
|
| pmid |
sentence |
| 10570155 |
Tyrosine 66 of R-Ras is phosphorylated by EphB2|. R-Ras, a small intracellular GTPase, regulates the binding of integrins to their ligands outside the cell. |Cells in which EphB2 is activated become poorly adherent to substrates coated with integrin ligands, and a tyrosine residue in the R-Ras effector domain is phosphorylated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RRAS
- 
- 