| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | BCL2 | – | phosphorylation down-regulates activity | 19917720 | SIGNOR-267987 | |
| PPP2CA | BCL2 | Ser87 | AAAGPALsPVPPVVH | dephosphorylation up-regulates activity | 15225643 | SIGNOR-248624 |
| LRRK2 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates activity | 25446991 | SIGNOR-279531 |
| JNK | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates activity | 11323415 | SIGNOR-261133 |
| MAPK1 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10677502 | SIGNOR-219217 |
| Gbeta | BCL2 | – | phosphorylation up-regulates | 10669763 | SIGNOR-270064 | |
| MAPK8 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 10567572 | SIGNOR-48038 |
| ERK1/2 | BCL2 | Thr74 | ARTSPLQtPAAPGAA | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244494 |
| MAPK1 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74923 |
| MAPK8 | BCL2 | Thr69 | SRDPVARtSPLQTPA | phosphorylation down-regulates | 10567572 | SIGNOR-72361 |
| MAPK8 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 18570871 | SIGNOR-179092 |
| MAPK1 | BCL2 | Thr74 | ARTSPLQtPAAPGAA | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74927 |
| MAPK3 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 10669763 | SIGNOR-74935 |
| p38 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 19336399 | SIGNOR-260450 |
| MAPK8 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 18570871 | SIGNOR-179088 |
| PRKCA | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 9738012 | SIGNOR-60120 |
| MAPK14 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 19336399 | SIGNOR-184936 |
| GSK3B | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation down-regulates quantity by destabilization | 29107113 | SIGNOR-279784 |
| ERK1/2 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244505 |
| ERK1/2 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244610 |
| MAPK8 | BCL2 | Thr69 | SRDPVARtSPLQTPA | phosphorylation down-regulates | 18570871 | SIGNOR-179096 |
| MAPK8 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 10567572 | SIGNOR-72125 |
| MAPK3 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74939 |
| MAPK8 | BCL2 | – | phosphorylation down-regulates | 10567572 | SIGNOR-72364 | |
| PPP2R5B | BCL2 | Ser70 | RDPVARTsPLQTPAA | dephosphorylation down-regulates | 18845789 | SIGNOR-181559 |
| MAPK14 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation down-regulates activity | 16714293 | SIGNOR-146786 |
| ERK1/2 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10677502 | SIGNOR-244501 |
| CDK1 | BCL2 | Thr56 | FSSQPGHtPHPAASR | phosphorylation up-regulates activity | 10766756 | SIGNOR-76837 |
| PPP2CB | BCL2 | Ser87 | AAAGPALsPVPPVVH | dephosphorylation up-regulates activity | 15225643 | SIGNOR-248589 |
| MAPK1 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74919 |
| MAPK3 | BCL2 | Thr74 | ARTSPLQtPAAPGAA | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74943 |
| MAPK1 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74931 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP2CA | dephosphorylation down-regulates ⊣ | BCL2 PSer87 | dephosphorylation down-regulates ⊣ | BCL2 | 15225643 | SIGNOR-248624 |
| LRRK2 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 25446991 | SIGNOR-279531 |
| JNK | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 11323415 | SIGNOR-261133 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10677502 | SIGNOR-219217 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 10567572 | SIGNOR-48038 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PThr74 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244494 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74923 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PThr69 | phosphorylation down-regulates ⊣ | BCL2 | 10567572 | SIGNOR-72361 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 18570871 | SIGNOR-179092 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PThr74 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74927 |
| MAPK3 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74935 |
| p38 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 19336399 | SIGNOR-260450 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 18570871 | SIGNOR-179088 |
| PRKCA | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 9738012 | SIGNOR-60120 |
| MAPK14 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 19336399 | SIGNOR-184936 |
| GSK3B | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation down-regulates ⊣ | BCL2 | 29107113 | SIGNOR-279784 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244505 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244610 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PThr69 | phosphorylation down-regulates ⊣ | BCL2 | 18570871 | SIGNOR-179096 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10567572 | SIGNOR-72125 |
| MAPK3 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74939 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | BCL2 PSer70 | dephosphorylation up-regulates → | BCL2 | 18845789 | SIGNOR-181559 |
| MAPK14 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation down-regulates ⊣ | BCL2 | 16714293 | SIGNOR-146786 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10677502 | SIGNOR-244501 |
| CDK1 | phosphorylation up-regulates → | BCL2 PThr56 | phosphorylation up-regulates → | BCL2 | 10766756 | SIGNOR-76837 |
| PPP2CB | dephosphorylation down-regulates ⊣ | BCL2 PSer87 | dephosphorylation down-regulates ⊣ | BCL2 | 15225643 | SIGNOR-248589 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74919 |
| MAPK3 | phosphorylation up-regulates → | BCL2 PThr74 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74943 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74931 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-267987 |
| PPP2CA | dephosphorylation → up-regulates activity | BCL2 | SIGNOR-248624 |
| LRRK2 | phosphorylation → up-regulates activity | BCL2 | SIGNOR-279531 |
| JNK | phosphorylation → up-regulates activity | BCL2 | SIGNOR-261133 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-219217 |
| Gbeta | phosphorylation → up-regulates | BCL2 | SIGNOR-270064 |
| MAPK8 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-48038 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244494 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74923 |
| MAPK8 | phosphorylation down-regulates | BCL2 | SIGNOR-72361 |
| MAPK8 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-179092 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74927 |
| MAPK3 | phosphorylation → up-regulates | BCL2 | SIGNOR-74935 |
| p38 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-260450 |
| MAPK8 | phosphorylation → up-regulates | BCL2 | SIGNOR-179088 |
| PRKCA | phosphorylation → up-regulates | BCL2 | SIGNOR-60120 |
| MAPK14 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-184936 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | BCL2 | SIGNOR-279784 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244505 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244610 |
| MAPK8 | phosphorylation down-regulates | BCL2 | SIGNOR-179096 |
| MAPK8 | phosphorylation → up-regulates | BCL2 | SIGNOR-72125 |
| MAPK3 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74939 |
| MAPK8 | phosphorylation down-regulates | BCL2 | SIGNOR-72364 |
| PPP2R5B | dephosphorylation down-regulates | BCL2 | SIGNOR-181559 |
| MAPK14 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-146786 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244501 |
| CDK1 | phosphorylation → up-regulates activity | BCL2 | SIGNOR-76837 |
| PPP2CB | dephosphorylation → up-regulates activity | BCL2 | SIGNOR-248589 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74919 |
| MAPK3 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74943 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74931 |
