Summary

Name BCL2
Full Name Apoptosis regulator Bcl-2
Synonyms BCL2_HUMAN
Primary ID P10415
Links - -
Type protein
Relations 70
Pathways Mitochondrial Control of Apoptosis, Malignant Melanoma, Acute Myeloid Leukemia, Inhibition of Apoptosis, Colorectal Carcinoma, Alzheimer Disease, KIT in AML, p53 in cancer, BCR-ABL in AML, FLT3 in AML, miRNA in AML, MLL in AML
Inhibitors Obatoclax mesylate; Obatoclax; N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide; 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]-N-[4-[[(2R)-4-(4-morpholinyl)-1-(phenylthio)butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide; gossypol; ABT-737
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.2
Publications: 5 Organism: Chlorocebus Aethiops, Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation BCL2 0.4
Publications: 3 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.37
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2 0.37
Publications: 5 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCL2 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, Colorectal Carcinoma, Inhibition of Apoptosis, Malignant Melanoma
+ down-regulates img/direct_inhibition.png phosphorylation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.64
Publications: 2 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png BCL2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Mitochondrial Control of Apoptosis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.72
Publications: 2 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.34
Publications: 2 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:Inhibition of Apoptosis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png binding BCL2 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BCL2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCL2 0.22
Publications: 1
Pathways:Malignant Melanoma
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.14
Publications: 1
Pathways:Alzheimer Disease, p53 in cancer
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization BCL2 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma
+ down-regulates img/indirect_inhibition.png Cell death 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BECN1 0.31
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BAK/BAX 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, MLL in AML, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ down-regulates activity img/direct_inhibition.png binding BCL2 0.42
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML, miRNA in AML, Colorectal Carcinoma, Mitochondrial Control of Apoptosis, Malignant Melanoma, p53 in cancer
+ down-regulates activity img/indirect_inhibition.png CYCS 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Mitochondrial Control of Apoptosis
+ down-regulates img/direct_inhibition.png binding BAK1 0.37
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression BCL2 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma
+ down-regulates img/indirect_inhibition.png DIABLO 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png HTRA2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation BCL2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional repression BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding BAX 0.39
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, p53 in cancer
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional activation BCL2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:MLL in AML
+ up-regulates quantity img/indirect-activation.png BCL2 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png chemical inhibition BCL2 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding BCL2 0.72
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
+ down-regulates img/indirect_inhibition.png Apoptosis 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, miRNA in AML, MLL in AML, Colorectal Carcinoma, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Malignant Melanoma