| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 19336399 | SIGNOR-184936 |
| MAPK8 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 18570871 | SIGNOR-179092 |
| MAPK1 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74931 |
| p38 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 19336399 | SIGNOR-260450 |
| PPP2CB | BCL2 | Ser87 | AAAGPALsPVPPVVH | dephosphorylation up-regulates activity | 15225643 | SIGNOR-248589 |
| PPP2CA | BCL2 | Ser87 | AAAGPALsPVPPVVH | dephosphorylation up-regulates activity | 15225643 | SIGNOR-248624 |
| ERK1/2 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-244505 |
| MAPK8 | BCL2 | Ser87 | AAAGPALsPVPPVVH | phosphorylation down-regulates activity | 10567572 | SIGNOR-48038 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 19336399 | SIGNOR-184936 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 18570871 | SIGNOR-179092 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74931 |
| p38 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 19336399 | SIGNOR-260450 |
| PPP2CB | dephosphorylation down-regulates ⊣ | BCL2 PSer87 | dephosphorylation down-regulates ⊣ | BCL2 | 15225643 | SIGNOR-248589 |
| PPP2CA | dephosphorylation down-regulates ⊣ | BCL2 PSer87 | dephosphorylation down-regulates ⊣ | BCL2 | 15225643 | SIGNOR-248624 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-244505 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer87 | phosphorylation down-regulates ⊣ | BCL2 | 10567572 | SIGNOR-48038 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-184936 |
| MAPK8 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-179092 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74931 |
| p38 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-260450 |
| PPP2CB | dephosphorylation → up-regulates activity | BCL2 | SIGNOR-248589 |
| PPP2CA | dephosphorylation → up-regulates activity | BCL2 | SIGNOR-248624 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244505 |
| MAPK8 | phosphorylation → down-regulates activity | BCL2 | SIGNOR-48038 |
