| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 10669763 | SIGNOR-74935 |
| MAPK8 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 18570871 | SIGNOR-179088 |
| MAPK8 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 10567572 | SIGNOR-72125 |
| ERK1/2 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10677502 | SIGNOR-244501 |
| PRKCA | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates | 9738012 | SIGNOR-60120 |
| MAPK1 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10677502 | SIGNOR-219217 |
| JNK | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates activity | 11323415 | SIGNOR-261133 |
| GSK3B | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation down-regulates quantity by destabilization | 29107113 | SIGNOR-279784 |
| MAPK1 | BCL2 | Ser70 | RDPVARTsPLQTPAA | phosphorylation up-regulates quantity by stabilization | 10669763 | SIGNOR-74919 |
| PPP2R5B | BCL2 | Ser70 | RDPVARTsPLQTPAA | dephosphorylation down-regulates | 18845789 | SIGNOR-181559 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK3 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74935 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 18570871 | SIGNOR-179088 |
| MAPK8 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10567572 | SIGNOR-72125 |
| ERK1/2 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10677502 | SIGNOR-244501 |
| PRKCA | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 9738012 | SIGNOR-60120 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10677502 | SIGNOR-219217 |
| JNK | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 11323415 | SIGNOR-261133 |
| GSK3B | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation down-regulates ⊣ | BCL2 | 29107113 | SIGNOR-279784 |
| MAPK1 | phosphorylation up-regulates → | BCL2 PSer70 | phosphorylation up-regulates → | BCL2 | 10669763 | SIGNOR-74919 |
| PPP2R5B | dephosphorylation down-regulates ⊣ | BCL2 PSer70 | dephosphorylation up-regulates → | BCL2 | 18845789 | SIGNOR-181559 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK3 | phosphorylation → up-regulates | BCL2 | SIGNOR-74935 |
| MAPK8 | phosphorylation → up-regulates | BCL2 | SIGNOR-179088 |
| MAPK8 | phosphorylation → up-regulates | BCL2 | SIGNOR-72125 |
| ERK1/2 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-244501 |
| PRKCA | phosphorylation → up-regulates | BCL2 | SIGNOR-60120 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-219217 |
| JNK | phosphorylation → up-regulates activity | BCL2 | SIGNOR-261133 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | BCL2 | SIGNOR-279784 |
| MAPK1 | phosphorylation → up-regulates quantity by stabilization | BCL2 | SIGNOR-74919 |
| PPP2R5B | dephosphorylation down-regulates | BCL2 | SIGNOR-181559 |
