| Name | PIM1 |
| ID | P11309 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 38-290 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | CDC25C | – | phosphorylation up-regulates activity | 16356754 | SIGNOR-278298 | |
| PIM1 | YWHAZ | Ser64 | SSWRVVSsIEQKTEG | phosphorylation up-regulates activity | 34697370 | SIGNOR-277574 |
| PIM1 | UHRF1 | Ser311 | S-->R | phosphorylation down-regulates quantity by destabilization | 28394343 | SIGNOR-277349 |
| PIM1 | CXCR4 | Ser339 | GKRGGHSsVSTESES | phosphorylation up-regulates quantity | 26075720 | SIGNOR-278450 |
| PIM1 | HBP1 | Ser380 | MARQRRAsLSCGGPG | phosphorylation up-regulates activity | 28348080 | SIGNOR-277347 |
| PIM1 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates | 18593906 | SIGNOR-252967 |
| PIM1 | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-252966 |
| PIM1 | NOTCH1 | – | phosphorylation up-regulates activity | 27281612 | SIGNOR-279643 | |
| PIM1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates | 18593906 | SIGNOR-179304 |
| PIM1 | SMAD2 | – | phosphorylation up-regulates activity | 29472550 | SIGNOR-279090 | |
| PIM1 | ABCG2 | Thr362 | GEKKKKItVFKEISY | phosphorylation up-regulates activity | 18056989 | SIGNOR-264420 |
| PIM1 | AR | Ser215 | SGRAREAsGAPTSSK | phosphorylation down-regulates activity | 22986532 | SIGNOR-278177 |
| PIM1 | MDM2 | Ser166 | SSRRRAIsETEENSD | phosphorylation up-regulates quantity by stabilization | 18467333 | SIGNOR-178615 |
| PIM1 | RUNX3 | – | phosphorylation up-regulates quantity | 24266874 | SIGNOR-279547 | |
| PIM1 | PSMD2 | Ser361 | ENNRFGGsGSQVDSA | phosphorylation up-regulates activity | 31843888 | SIGNOR-273895 |
| PIM1 | NFATC1 | Thr339 | PVKSRKTtLEQPPSV | phosphorylation up-regulates activity | 31730483 | SIGNOR-276771 |
| PIM1 | AR | – | phosphorylation up-regulates activity | 34697370 | SIGNOR-277575 | |
| PIM1 | HBP1 | Ser372 | SAVYVLSsMARQRRA | phosphorylation up-regulates activity | 28348080 | SIGNOR-277346 |
| PIM1 | NFATC1 | Ser269 | PCNKRKYsLNGRQPP | phosphorylation up-regulates activity | 31730483 | SIGNOR-276769 |
| PIM1 | NFATC1 | Ser245 | PSTSPRAsVTEESWL | phosphorylation up-regulates activity | 31730483 | SIGNOR-276770 |
| PIM1 | RP9 | Ser212 | KKRKHKSsKSNEGSD | phosphorylation unknown | 10931201 | SIGNOR-263029 |
| PIM1 | MARK3 | Thr90 | AIKIIDKtQLNPTSL | phosphorylation down-regulates | 15319445 | SIGNOR-128264 |
| PIM1 | RPS19 | – | phosphorylation up-regulates | 16266891 | SIGNOR-141411 | |
| PIM1 | PLK1 | Thr210 | YDGERKKtLCGTPNY | phosphorylation down-regulates activity | 24771642 | SIGNOR-279749 |
| PIM1 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 17643117 | SIGNOR-156946 |
| PIM1 | SKP2 | Ser64 | SNLGHPEsPPRKRLK | phosphorylation up-regulates activity | 20663873 | SIGNOR-259818 |
| PIM1 | RUNX1 | – | phosphorylation up-regulates activity | 16684349 | SIGNOR-278976 | |
| PIM1 | NFATC1 | Ser335 | GDGVPVKsRKTTLEQ | phosphorylation up-regulates activity | 31730483 | SIGNOR-276776 |
| PIM1 | MYC | Ser62 | S-->E | phosphorylation up-regulates quantity by stabilization | 29472550 | SIGNOR-279249 |
| PIM1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18593906 | SIGNOR-179296 |
| PIM1 | NFATC1 | Thr154 | SSKRSPStATLSLPS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276777 |
| PIM1 | HIF1A | Thr455 | LAMSPLPtAETPKPL | phosphorylation up-regulates quantity by stabilization | 34211090 | SIGNOR-277311 |
| PIM1 | SKP2 | Thr417 | WGIKCRLtLQKPSCL | phosphorylation up-regulates activity | 20663873 | SIGNOR-259817 |
| PIM1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 18593906 | SIGNOR-179308 |
| PIM1 | BAD | Ser75 | EIRSRHSsYPAGTED | phosphorylation down-regulates activity | 16403219 | SIGNOR-249607 |
| PIM1 | NFATC1 | Thr338 | VPVKSRKtTLEQPPS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276775 |
| PIM1 | NDRG1 | Ser330 | LMRSRTAsGSSVTSL | phosphorylation down-regulates activity | 33398037 | SIGNOR-279308 |
| PIM1 | EPAS1 | Ser435 | GKAILPPsQPWATEL | phosphorylation up-regulates quantity by stabilization | 34211090 | SIGNOR-277310 |
| PIM1 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates | 19749799 | SIGNOR-187905 |
| PIM1 | MDM2 | Ser186 | RQRKRHKsDSISLSF | phosphorylation up-regulates | 18467333 | SIGNOR-178619 |
| PIM1 | NFATC1 | Ser153 | PSSKRSPsTATLSLP | phosphorylation up-regulates activity | 31730483 | SIGNOR-276774 |
| PIM1 | FLT3 | Tyr591 | SSDNEYFyVDFREYE | phosphorylation up-regulates quantity | 24040307 | SIGNOR-259927 |
| PIM1 | NFATC1 | Ser151 | VLPSSKRsPSTATLS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276779 |
| PIM1 | SKP2 | Ser72 | PPRKRLKsKGSDKDF | phosphorylation up-regulates activity | 20663873 | SIGNOR-259819 |
| PIM1 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 16403219 | SIGNOR-250390 |
| PIM1 | MARK3 | Thr95 | DKTQLNPtSLQKLFR | phosphorylation down-regulates | 15319445 | SIGNOR-128268 |
| PIM1 | NFATC1 | Ser256 | ESWLGARsSRPASPC | phosphorylation up-regulates activity | 31730483 | SIGNOR-276768 |
| PIM1 | BAD | Ser99 | PFRGRSRsAPPNLWA | phosphorylation down-regulates activity | 16403219 | SIGNOR-250392 |
| PIM1 | MYC | – | phosphorylation up-regulates activity | 25280219 | SIGNOR-261557 | |
| PIM1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18593906 | SIGNOR-179300 |
| PIM1 | CDKN1A | Thr145 | QGRKRRQtSMTDFYH | phosphorylation up-regulates quantity by stabilization | 20307683 | SIGNOR-164642 |
| PIM1 | CDKN1A | Ser146 | GRKRRQTsMTDFYHS | phosphorylation up-regulates quantity by stabilization | 31575057 | SIGNOR-262961 |
| PIM1 | Histone H3 | – | phosphorylation down-regulates activity | 17643117 | SIGNOR-265366 | |
| PIM1 | FZR1 | – | phosphorylation down-regulates activity | 20663873 | SIGNOR-259820 | |
| PIM1 | MARK3 | Ser96 | KTQLNPTsLQKLFRE | phosphorylation down-regulates | 15319445 | SIGNOR-128260 |
| PIM1 | NFATC1 | Ser257 | SWLGARSsRPASPCN | phosphorylation up-regulates activity | 31730483 | SIGNOR-276767 |
| PIM1 | RP9 | Ser214 | RKHKSSKsNEGSDSE | phosphorylation unknown | 10931201 | SIGNOR-263030 |
| PIM1 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 19911008 | SIGNOR-189125 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | YWHAZ PSer64 | phosphorylation up-regulates → | YWHAZ | 34697370 | SIGNOR-277574 |
| PIM1 | phosphorylation up-regulates → | UHRF1 PSer311 | phosphorylation down-regulates ⊣ | UHRF1 | 28394343 | SIGNOR-277349 |
| PIM1 | phosphorylation up-regulates → | CXCR4 PSer339 | phosphorylation up-regulates → | CXCR4 | 26075720 | SIGNOR-278450 |
| PIM1 | phosphorylation up-regulates → | HBP1 PSer380 | phosphorylation up-regulates → | HBP1 | 28348080 | SIGNOR-277347 |
| PIM1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 18593906 | SIGNOR-252967 |
| PIM1 | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 18593906 | SIGNOR-252966 |
| PIM1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-179304 |
| PIM1 | phosphorylation up-regulates → | ABCG2 PThr362 | phosphorylation up-regulates → | ABCG2 | 18056989 | SIGNOR-264420 |
| PIM1 | phosphorylation up-regulates → | AR PSer215 | phosphorylation down-regulates ⊣ | AR | 22986532 | SIGNOR-278177 |
| PIM1 | phosphorylation up-regulates → | MDM2 PSer166 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-178615 |
| PIM1 | phosphorylation up-regulates → | PSMD2 PSer361 | phosphorylation up-regulates → | PSMD2 | 31843888 | SIGNOR-273895 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PThr339 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276771 |
| PIM1 | phosphorylation up-regulates → | HBP1 PSer372 | phosphorylation up-regulates → | HBP1 | 28348080 | SIGNOR-277346 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer269 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276769 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer245 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276770 |
| PIM1 | phosphorylation up-regulates → | RP9 PSer212 | phosphorylation down-regulates ⊣ | RP9 | 10931201 | SIGNOR-263029 |
| PIM1 | phosphorylation up-regulates → | MARK3 PThr90 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-128264 |
| PIM1 | phosphorylation up-regulates → | PLK1 PThr210 | phosphorylation down-regulates ⊣ | PLK1 | 24771642 | SIGNOR-279749 |
| PIM1 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 17643117 | SIGNOR-156946 |
| PIM1 | phosphorylation up-regulates → | SKP2 PSer64 | phosphorylation up-regulates → | SKP2 | 20663873 | SIGNOR-259818 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer335 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276776 |
| PIM1 | phosphorylation up-regulates → | MYC PSer62 | phosphorylation up-regulates → | MYC | 29472550 | SIGNOR-279249 |
| PIM1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-179296 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PThr154 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276777 |
| PIM1 | phosphorylation up-regulates → | HIF1A PThr455 | phosphorylation up-regulates → | HIF1A | 34211090 | SIGNOR-277311 |
| PIM1 | phosphorylation up-regulates → | SKP2 PThr417 | phosphorylation up-regulates → | SKP2 | 20663873 | SIGNOR-259817 |
| PIM1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 18593906 | SIGNOR-179308 |
| PIM1 | phosphorylation up-regulates → | BAD PSer75 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-249607 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PThr338 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276775 |
| PIM1 | phosphorylation up-regulates → | NDRG1 PSer330 | phosphorylation down-regulates ⊣ | NDRG1 | 33398037 | SIGNOR-279308 |
| PIM1 | phosphorylation up-regulates → | EPAS1 PSer435 | phosphorylation up-regulates → | EPAS1 | 34211090 | SIGNOR-277310 |
| PIM1 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 19749799 | SIGNOR-187905 |
| PIM1 | phosphorylation up-regulates → | MDM2 PSer186 | phosphorylation up-regulates → | MDM2 | 18467333 | SIGNOR-178619 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer153 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276774 |
| PIM1 | phosphorylation up-regulates → | FLT3 PTyr591 | phosphorylation up-regulates → | FLT3 | 24040307 | SIGNOR-259927 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer151 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276779 |
| PIM1 | phosphorylation up-regulates → | SKP2 PSer72 | phosphorylation up-regulates → | SKP2 | 20663873 | SIGNOR-259819 |
| PIM1 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250390 |
| PIM1 | phosphorylation up-regulates → | MARK3 PThr95 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-128268 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer256 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276768 |
| PIM1 | phosphorylation up-regulates → | BAD PSer99 | phosphorylation down-regulates ⊣ | BAD | 16403219 | SIGNOR-250392 |
| PIM1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18593906 | SIGNOR-179300 |
| PIM1 | phosphorylation up-regulates → | CDKN1A PThr145 | phosphorylation up-regulates → | CDKN1A | 20307683 | SIGNOR-164642 |
| PIM1 | phosphorylation up-regulates → | CDKN1A PSer146 | phosphorylation up-regulates → | CDKN1A | 31575057 | SIGNOR-262961 |
| PIM1 | phosphorylation up-regulates → | MARK3 PSer96 | phosphorylation down-regulates ⊣ | MARK3 | 15319445 | SIGNOR-128260 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer257 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276767 |
| PIM1 | phosphorylation up-regulates → | RP9 PSer214 | phosphorylation down-regulates ⊣ | RP9 | 10931201 | SIGNOR-263030 |
| PIM1 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 19911008 | SIGNOR-189125 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM1 | phosphorylation → up-regulates activity | CDC25C | SIGNOR-278298 |
| PIM1 | phosphorylation → up-regulates activity | YWHAZ | SIGNOR-277574 |
| PIM1 | phosphorylation down-regulates quantity by destabilization | UHRF1 | SIGNOR-277349 |
| PIM1 | phosphorylation → up-regulates quantity | CXCR4 | SIGNOR-278450 |
| PIM1 | phosphorylation → up-regulates activity | HBP1 | SIGNOR-277347 |
| PIM1 | phosphorylation down-regulates | FOXO | SIGNOR-252967 |
| PIM1 | phosphorylation down-regulates | FOXO | SIGNOR-252966 |
| PIM1 | phosphorylation → up-regulates activity | NOTCH1 | SIGNOR-279643 |
| PIM1 | phosphorylation down-regulates | FOXO3 | SIGNOR-179304 |
| PIM1 | phosphorylation → up-regulates activity | SMAD2 | SIGNOR-279090 |
| PIM1 | phosphorylation → up-regulates activity | ABCG2 | SIGNOR-264420 |
| PIM1 | phosphorylation → down-regulates activity | AR | SIGNOR-278177 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | MDM2 | SIGNOR-178615 |
| PIM1 | phosphorylation → up-regulates quantity | RUNX3 | SIGNOR-279547 |
| PIM1 | phosphorylation → up-regulates activity | PSMD2 | SIGNOR-273895 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276771 |
| PIM1 | phosphorylation → up-regulates activity | AR | SIGNOR-277575 |
| PIM1 | phosphorylation → up-regulates activity | HBP1 | SIGNOR-277346 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276769 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276770 |
| PIM1 | phosphorylation → unknown | RP9 | SIGNOR-263029 |
| PIM1 | phosphorylation down-regulates | MARK3 | SIGNOR-128264 |
| PIM1 | phosphorylation → up-regulates | RPS19 | SIGNOR-141411 |
| PIM1 | phosphorylation → down-regulates activity | PLK1 | SIGNOR-279749 |
| PIM1 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-156946 |
| PIM1 | phosphorylation → up-regulates activity | SKP2 | SIGNOR-259818 |
| PIM1 | phosphorylation → up-regulates activity | RUNX1 | SIGNOR-278976 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276776 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | MYC | SIGNOR-279249 |
| PIM1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179296 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276777 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | HIF1A | SIGNOR-277311 |
| PIM1 | phosphorylation → up-regulates activity | SKP2 | SIGNOR-259817 |
| PIM1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-179308 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-249607 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276775 |
| PIM1 | phosphorylation → down-regulates activity | NDRG1 | SIGNOR-279308 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | EPAS1 | SIGNOR-277310 |
| PIM1 | phosphorylation down-regulates | MAP3K5 | SIGNOR-187905 |
| PIM1 | phosphorylation → up-regulates | MDM2 | SIGNOR-178619 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276774 |
| PIM1 | phosphorylation → up-regulates quantity | FLT3 | SIGNOR-259927 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276779 |
| PIM1 | phosphorylation → up-regulates activity | SKP2 | SIGNOR-259819 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-250390 |
| PIM1 | phosphorylation down-regulates | MARK3 | SIGNOR-128268 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276768 |
| PIM1 | phosphorylation → down-regulates activity | BAD | SIGNOR-250392 |
| PIM1 | phosphorylation → up-regulates activity | MYC | SIGNOR-261557 |
| PIM1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-179300 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-164642 |
| PIM1 | phosphorylation → up-regulates quantity by stabilization | CDKN1A | SIGNOR-262961 |
| PIM1 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265366 |
| PIM1 | phosphorylation → down-regulates activity | FZR1 | SIGNOR-259820 |
| PIM1 | phosphorylation down-regulates | MARK3 | SIGNOR-128260 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276767 |
| PIM1 | phosphorylation → unknown | RP9 | SIGNOR-263030 |
| PIM1 | phosphorylation → up-regulates | RELA | SIGNOR-189125 |