Summary

Name PIM1
Full Name Serine/threonine-protein kinase pim-1
Synonyms PIM1_HUMAN
Primary ID P11309
Links - -
Type protein
Relations 42
Pathways Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
Inhibitors SGI-1776
Function Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.38
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CDKN1A 0.497
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MDM2 0.398
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.398
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD signaling
+ img/unknown.png phosphorylation RP9 0.2
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.396
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates img/direct_inhibition.png phosphorylation FOXO 0.397
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation RELA 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3-ITD in AML
+ up-regulates activity img/direct-activation.png phosphorylation PSMD2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SKP2 0.347
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PIM1 0.27
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation ABCB1 0.452
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.286
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MARK3 0.428
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.391
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation CDKN1B 0.391
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates activity img/direct_inhibition.png phosphorylation FOXO3 0.396
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ up-regulates activity img/direct-activation.png phosphorylation ABCG2 0.367
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png phosphorylation FLT3 0.437
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIM1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation FZR1 0.321
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PIM1 0.389
Publications: 3 Organism: Mus Musculus, , Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates img/indirect_inhibition.png Apoptosis 0.7
Publications: 1
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIM1 0.437
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ down-regulates img/direct_inhibition.png chemical inhibition PIM1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PIM1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ down-regulates img/indirect_inhibition.png Cell_death 0.7
Publications: 1
+ down-regulates activity img/direct_inhibition.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MYC 0.684
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling
+ up-regulates img/direct-activation.png phosphorylation RPS19 0.452
Publications: 1 Organism: Homo Sapiens