Summary

Name PIM1
Full Name Serine/threonine-protein kinase pim-1
Synonyms PIM1_HUMAN
Primary ID P11309
Links - -
Type protein
Relations 24
Inhibitors SGI-1776
Function Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HIST1H3A 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.25
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MDM2 0.20
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FOXO3 0.30
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RELA 0.18
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MARK3 0.63
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1A 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CDKN1B 0.24
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png unknown Apoptosis
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PIM1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PIM1 0.26
Publications: 2 Organism: , Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIM1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS19 0.62
Publications: 1 Organism: Homo Sapiens