| Name | FGFR1 |
| ID | P11362 |
| Role | kinase |
| Enzymatic Domains |
Ig-like C2-type 1 25-119
Ig-like C2-type 2 158-246
Ig-like C2-type 3 255-357
Protein kinase 478-767 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR1 | PDPK1 | – | phosphorylation up-regulates activity | 22195962 | SIGNOR-279174 | |
| FGFR1 | SYNCRIP | Tyr373 | RVKKLKDyAFIHFDE | phosphorylation down-regulates | 12601080 | SIGNOR-98704 |
| FGFR1 | LDHA | Tyr10 | TLKDQLIyNLLKEEQ | phosphorylation up-regulates | 21969607 | SIGNOR-176730 |
| FGFR1 | LDHA | Tyr83 | KIVSGKDyNVTANSK | phosphorylation up-regulates | 21969607 | SIGNOR-176734 |
| FGFR1 | FGFR1 | Tyr280 | VEFMCKVySDPQPHI | phosphorylation up-regulates | 12601080 | SIGNOR-98626 |
| FGFR1 | FGFR1 | Tyr605 | KDLVSCAyQVARGME | phosphorylation up-regulates | 12601080 | SIGNOR-98634 |
| FGFR1 | FGFR1 | Tyr463 | MLAGVSEyELPEDPR | phosphorylation up-regulates | 19224897 | SIGNOR-235762 |
| FGFR1 | FGFR1 | Tyr583 | RRPPGLEyCYNPSHN | phosphorylation up-regulates | 19224897 | SIGNOR-235906 |
| FGFR1 | FGFR1 | Tyr585 | PPGLEYCyNPSHNPE | phosphorylation up-regulates | 19224897 | SIGNOR-235682 |
| FGFR1 | FGFR1 | Tyr730 | SNCTNELyMMMRDCW | phosphorylation up-regulates | 19224897 | SIGNOR-236191 |
| FGFR1 | FGFR1 | Tyr766 | ALTSNQEyLDLSMPL | phosphorylation up-regulates | 19224897 | SIGNOR-236203 |
| FGFR1 | FGFR1 | Tyr154 | NRMPVAPyWTSPEKM | phosphorylation up-regulates | 8443592 | SIGNOR-98622 |
| FGFR1 | FGFR1 | Tyr307 | IGPDNLPyVQILKTA | phosphorylation up-regulates | 8443592 | SIGNOR-98630 |
| FGFR1 | FGFR1 | Tyr463 | MLAGVSEyELPEDPR | phosphorylation up-regulates | 8622701 | SIGNOR-236179 |
| FGFR1 | FGFR1 | Tyr583 | RRPPGLEyCYNPSHN | phosphorylation up-regulates | 8622701 | SIGNOR-236183 |
| FGFR1 | FGFR1 | Tyr585 | PPGLEYCyNPSHNPE | phosphorylation up-regulates | 8622701 | SIGNOR-236187 |
| FGFR1 | FGFR1 | Tyr653 | RDIHHIDyYKKTTNG | phosphorylation up-regulates | 8622701 | SIGNOR-236195 |
| FGFR1 | FGFR1 | Tyr654 | DIHHIDYyKKTTNGR | phosphorylation up-regulates | 8622701 | SIGNOR-236199 |
| FGFR1 | FGFR1 | Tyr730 | SNCTNELyMMMRDCW | phosphorylation up-regulates | 8622701 | SIGNOR-235686 |
| FGFR1 | PGAM1 | – | phosphorylation up-regulates activity | 23653202 | SIGNOR-279175 | |
| FGFR1 | ACAT1 | Tyr407 | HALKQGEyGLASICN | phosphorylation up-regulates activity | 27867011 | SIGNOR-264423 |
| FGFR1 | BCAR1 | Tyr128 | SKAQQGLyQVPGPSP | phosphorylation up-regulates | 11019781 | SIGNOR-82760 |
| FGFR1 | BCAR1 | Tyr128 | SKAQQGLyQVPGPSP | phosphorylation up-regulates | 12601080 | SIGNOR-98488 |
| FGFR1 | BCAR1 | Tyr249 | APGPQDIyDVPPVRG | phosphorylation up-regulates | 12601080 | SIGNOR-98492 |
| FGFR1 | BCAR1 | Tyr306 | PSNHHAVyDVPPSVS | phosphorylation up-regulates | 12601080 | SIGNOR-98496 |
| FGFR1 | BCAR1 | Tyr327 | PLLREETyDVPPAFA | phosphorylation up-regulates | 12601080 | SIGNOR-98500 |
| FGFR1 | BCAR1 | Tyr410 | GVVDSGVyAVPPPAE | phosphorylation up-regulates | 12601080 | SIGNOR-98569 |
| FGFR1 | CTTN | Tyr446 | GTEPEPVySMEAADY | phosphorylation down-regulates | 12601080 | SIGNOR-98618 |
| FGFR1 | PDK1 | Tyr136 | AEDAKAIyDFTDTVI | phosphorylation up-regulates | 22195962 | SIGNOR-191719 |
| FGFR1 | PDK1 | Tyr243 | ARRLCDLyYINSPEL | phosphorylation up-regulates | 22195962 | SIGNOR-191723 |
| FGFR1 | PDK1 | Tyr244 | RRLCDLYyINSPELE | phosphorylation up-regulates | 22195962 | SIGNOR-193454 |
| FGFR1 | FRS2 | Tyr196 | AEEQVHTyVNTTGVQ | phosphorylation up-regulates activity | 25394172 | SIGNOR-280013 |
| FGFR1 | FRS2 | – | phosphorylation up-regulates activity | 9182757 | SIGNOR-236944 | |
| FGFR1 | PCDH15 | – | phosphorylation up-regulates activity | 30061390 | SIGNOR-280014 | |
| FGFR1 | PDP1 | Tyr94 | SILKANEySFKVPEF | phosphorylation down-regulates activity | 24962578 | SIGNOR-276640 |
| FGFR1 | AMOTL2 | Tyr107 | KGEELPTyEEAKAHS | phosphorylation up-regulates activity | 21937427 | SIGNOR-271869 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| FGFR1 | phosphorylation up-regulates → | SYNCRIP PTyr373 | phosphorylation down-regulates ⊣ | SYNCRIP | 12601080 | SIGNOR-98704 |
| FGFR1 | phosphorylation up-regulates → | LDHA PTyr10 | phosphorylation up-regulates → | LDHA | 21969607 | SIGNOR-176730 |
| FGFR1 | phosphorylation up-regulates → | LDHA PTyr83 | phosphorylation up-regulates → | LDHA | 21969607 | SIGNOR-176734 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr280 | phosphorylation up-regulates → | FGFR1 | 12601080 | SIGNOR-98626 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr605 | phosphorylation up-regulates → | FGFR1 | 12601080 | SIGNOR-98634 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr463 | phosphorylation up-regulates → | FGFR1 | 19224897 | SIGNOR-235762 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr583 | phosphorylation up-regulates → | FGFR1 | 19224897 | SIGNOR-235906 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr585 | phosphorylation up-regulates → | FGFR1 | 19224897 | SIGNOR-235682 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr730 | phosphorylation up-regulates → | FGFR1 | 19224897 | SIGNOR-236191 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr766 | phosphorylation up-regulates → | FGFR1 | 19224897 | SIGNOR-236203 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr154 | phosphorylation up-regulates → | FGFR1 | 8443592 | SIGNOR-98622 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr307 | phosphorylation up-regulates → | FGFR1 | 8443592 | SIGNOR-98630 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr463 | phosphorylation up-regulates → | FGFR1 | 8622701 | SIGNOR-236179 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr583 | phosphorylation up-regulates → | FGFR1 | 8622701 | SIGNOR-236183 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr585 | phosphorylation up-regulates → | FGFR1 | 8622701 | SIGNOR-236187 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr653 | phosphorylation up-regulates → | FGFR1 | 8622701 | SIGNOR-236195 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr654 | phosphorylation up-regulates → | FGFR1 | 8622701 | SIGNOR-236199 |
| FGFR1 | phosphorylation up-regulates → | FGFR1 PTyr730 | phosphorylation up-regulates → | FGFR1 | 8622701 | SIGNOR-235686 |
| FGFR1 | phosphorylation up-regulates → | ACAT1 PTyr407 | phosphorylation up-regulates → | ACAT1 | 27867011 | SIGNOR-264423 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr128 | phosphorylation up-regulates → | BCAR1 | 11019781 | SIGNOR-82760 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr128 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98488 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr249 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98492 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr306 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98496 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr327 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98500 |
| FGFR1 | phosphorylation up-regulates → | BCAR1 PTyr410 | phosphorylation up-regulates → | BCAR1 | 12601080 | SIGNOR-98569 |
| FGFR1 | phosphorylation up-regulates → | CTTN PTyr446 | phosphorylation down-regulates ⊣ | CTTN | 12601080 | SIGNOR-98618 |
| FGFR1 | phosphorylation up-regulates → | PDK1 PTyr136 | phosphorylation up-regulates → | PDK1 | 22195962 | SIGNOR-191719 |
| FGFR1 | phosphorylation up-regulates → | PDK1 PTyr243 | phosphorylation up-regulates → | PDK1 | 22195962 | SIGNOR-191723 |
| FGFR1 | phosphorylation up-regulates → | PDK1 PTyr244 | phosphorylation up-regulates → | PDK1 | 22195962 | SIGNOR-193454 |
| FGFR1 | phosphorylation up-regulates → | FRS2 PTyr196 | phosphorylation up-regulates → | FRS2 | 25394172 | SIGNOR-280013 |
| FGFR1 | phosphorylation up-regulates → | PDP1 PTyr94 | phosphorylation down-regulates ⊣ | PDP1 | 24962578 | SIGNOR-276640 |
| FGFR1 | phosphorylation up-regulates → | AMOTL2 PTyr107 | phosphorylation up-regulates → | AMOTL2 | 21937427 | SIGNOR-271869 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| FGFR1 | phosphorylation → up-regulates activity | PDPK1 | SIGNOR-279174 |
| FGFR1 | phosphorylation down-regulates | SYNCRIP | SIGNOR-98704 |
| FGFR1 | phosphorylation → up-regulates | LDHA | SIGNOR-176730 |
| FGFR1 | phosphorylation → up-regulates | LDHA | SIGNOR-176734 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-98626 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-98634 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-235762 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-235906 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-235682 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236191 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236203 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-98622 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-98630 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236179 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236183 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236187 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236195 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-236199 |
| FGFR1 | phosphorylation → up-regulates | FGFR1 | SIGNOR-235686 |
| FGFR1 | phosphorylation → up-regulates activity | PGAM1 | SIGNOR-279175 |
| FGFR1 | phosphorylation → up-regulates activity | ACAT1 | SIGNOR-264423 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-82760 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98488 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98492 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98496 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98500 |
| FGFR1 | phosphorylation → up-regulates | BCAR1 | SIGNOR-98569 |
| FGFR1 | phosphorylation down-regulates | CTTN | SIGNOR-98618 |
| FGFR1 | phosphorylation → up-regulates | PDK1 | SIGNOR-191719 |
| FGFR1 | phosphorylation → up-regulates | PDK1 | SIGNOR-191723 |
| FGFR1 | phosphorylation → up-regulates | PDK1 | SIGNOR-193454 |
| FGFR1 | phosphorylation → up-regulates activity | FRS2 | SIGNOR-280013 |
| FGFR1 | phosphorylation → up-regulates activity | FRS2 | SIGNOR-236944 |
| FGFR1 | phosphorylation → up-regulates activity | PCDH15 | SIGNOR-280014 |
| FGFR1 | phosphorylation → down-regulates activity | PDP1 | SIGNOR-276640 |
| FGFR1 | phosphorylation → up-regulates activity | AMOTL2 | SIGNOR-271869 |