Summary

Name FGFR1
Full Name Fibroblast growth factor receptor 1
Synonyms FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr | BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Primary ID P11362
Links - -
Type protein
Relations 52
Pathways Luminal Breast Cancer
Inhibitors PD173074; BGJ-398; sorafenib tosylate; ponatinib; regorafenib; ; Brivanib alaninate; nintedanib; (2R)-1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol; 2-Hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylic acid; pazopanib; orantinib
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.36
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation FGFR1 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LDHA 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation BCAR1 0.2
Publications: 6 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PDK1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FGFR1 0.49
Publications: 15 Organism: Homo Sapiens, Rattus Norvegicus
Pathways:Luminal Breast Cancer
+ down-regulates img/direct_inhibition.png phosphorylation SYNCRIP 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTTN 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MEK1/2 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Luminal Breast Cancer
+ up-regulates img/direct-activation.png binding FGFR1 0.38
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FGFR1 0.45
Publications: 1 Organism: Homo Sapiens
Tissue: Adipose Tissue
+ up-regulates img/direct-activation.png binding FGFR1 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAP2K1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FRS2 0.63
Publications: 1 Organism: Rattus Norvegicus
Pathways:Luminal Breast Cancer
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FGFR1 0.14
Publications: 1 Organism: Homo Sapiens