Entity Details

Name FGFR1
ID P11362
Role substrate
Enzymatic Domains
Ig-like C2-type 1 25-119
Ig-like C2-type 2 158-246
Ig-like C2-type 3 255-357
Protein kinase 478-767
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
FGFR1FGFR1Tyr463MLAGVSEyELPEDPRphosphorylation
up-regulates
8622701SIGNOR-236179
FGFR1FGFR1Tyr605KDLVSCAyQVARGMEphosphorylation
up-regulates
12601080SIGNOR-98634
FGFR1FGFR1Tyr654DIHHIDYyKKTTNGRphosphorylation
up-regulates
8622701SIGNOR-236199
RPS6KA3FGFR1Ser789DTRSSTCsSGEDSVFphosphorylation
down-regulates quantity
24141780SIGNOR-276599
FGFR1FGFR1Tyr280VEFMCKVySDPQPHIphosphorylation
up-regulates
12601080SIGNOR-98626
MAPK3FGFR1Ser777SMPLDQYsPSFPDTRphosphorylation
down-regulates
23405013SIGNOR-200884
FGFR1FGFR1Tyr766ALTSNQEyLDLSMPLphosphorylation
up-regulates
19224897SIGNOR-236203
FGFR1FGFR1Tyr730SNCTNELyMMMRDCWphosphorylation
up-regulates
8622701SIGNOR-235686
PRKCEFGFR1Ser779PLDQYSPsFPDTRSSphosphorylation
up-regulates
23564461SIGNOR-201671
ERK1/2FGFR1Ser777SMPLDQYsPSFPDTRphosphorylation
down-regulates
23405013SIGNOR-244541
FGFR1FGFR1Tyr585PPGLEYCyNPSHNPEphosphorylation
up-regulates
19224897SIGNOR-235682
MAPK1FGFR1Ser777SMPLDQYsPSFPDTRphosphorylation
down-regulates
23405013SIGNOR-200880
FGFR1FGFR1Tyr307IGPDNLPyVQILKTAphosphorylation
up-regulates
8443592SIGNOR-98630
GbetaFGFR1phosphorylation
down-regulates
23405013SIGNOR-270013
DUSP26FGFR1dephosphorylation
down-regulates activity
28701747SIGNOR-277104
FGFR1FGFR1Tyr583RRPPGLEyCYNPSHNphosphorylation
up-regulates
8622701SIGNOR-236183
EPHA4FGFR1phosphorylation
up-regulates activity
22040915SIGNOR-280007
FGFR1FGFR1Tyr463MLAGVSEyELPEDPRphosphorylation
up-regulates
19224897SIGNOR-235762
FGFR1FGFR1Tyr730SNCTNELyMMMRDCWphosphorylation
up-regulates
19224897SIGNOR-236191
FGFR1FGFR1Tyr653 RDIHHIDyYKKTTNGphosphorylation
up-regulates
8622701SIGNOR-236195
FGFR1FGFR1Tyr154NRMPVAPyWTSPEKMphosphorylation
up-regulates
8443592SIGNOR-98622
MAPK14FGFR1Ser777SMPLDQYsPSFPDTRphosphorylation
down-regulates
20626350SIGNOR-166598
FGFR1FGFR1Tyr583RRPPGLEyCYNPSHNphosphorylation
up-regulates
19224897SIGNOR-235906
FGFR1FGFR1Tyr585PPGLEYCyNPSHNPEphosphorylation
up-regulates
8622701SIGNOR-236187
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
FGFR1phosphorylation
up-regulates
FGFR1
PTyr463
phosphorylation
up-regulates
FGFR18622701SIGNOR-236179
FGFR1phosphorylation
up-regulates
FGFR1
PTyr605
phosphorylation
up-regulates
FGFR112601080SIGNOR-98634
FGFR1phosphorylation
up-regulates
FGFR1
PTyr654
phosphorylation
up-regulates
FGFR18622701SIGNOR-236199
RPS6KA3phosphorylation
up-regulates
FGFR1
PSer789
phosphorylation
down-regulates
FGFR124141780SIGNOR-276599
FGFR1phosphorylation
up-regulates
FGFR1
PTyr280
phosphorylation
up-regulates
FGFR112601080SIGNOR-98626
MAPK3phosphorylation
up-regulates
FGFR1
PSer777
phosphorylation
down-regulates
FGFR123405013SIGNOR-200884
FGFR1phosphorylation
up-regulates
FGFR1
PTyr766
phosphorylation
up-regulates
FGFR119224897SIGNOR-236203
FGFR1phosphorylation
up-regulates
FGFR1
PTyr730
phosphorylation
up-regulates
FGFR18622701SIGNOR-235686
PRKCEphosphorylation
up-regulates
FGFR1
PSer779
phosphorylation
up-regulates
FGFR123564461SIGNOR-201671
ERK1/2phosphorylation
up-regulates
FGFR1
PSer777
phosphorylation
down-regulates
FGFR123405013SIGNOR-244541
FGFR1phosphorylation
up-regulates
FGFR1
PTyr585
phosphorylation
up-regulates
FGFR119224897SIGNOR-235682
MAPK1phosphorylation
up-regulates
FGFR1
PSer777
phosphorylation
down-regulates
FGFR123405013SIGNOR-200880
FGFR1phosphorylation
up-regulates
FGFR1
PTyr307
phosphorylation
up-regulates
FGFR18443592SIGNOR-98630
FGFR1phosphorylation
up-regulates
FGFR1
PTyr583
phosphorylation
up-regulates
FGFR18622701SIGNOR-236183
FGFR1phosphorylation
up-regulates
FGFR1
PTyr463
phosphorylation
up-regulates
FGFR119224897SIGNOR-235762
FGFR1phosphorylation
up-regulates
FGFR1
PTyr730
phosphorylation
up-regulates
FGFR119224897SIGNOR-236191
FGFR1phosphorylation
up-regulates
FGFR1
PTyr653
phosphorylation
up-regulates
FGFR18622701SIGNOR-236195
FGFR1phosphorylation
up-regulates
FGFR1
PTyr154
phosphorylation
up-regulates
FGFR18443592SIGNOR-98622
MAPK14phosphorylation
up-regulates
FGFR1
PSer777
phosphorylation
down-regulates
FGFR120626350SIGNOR-166598
FGFR1phosphorylation
up-regulates
FGFR1
PTyr583
phosphorylation
up-regulates
FGFR119224897SIGNOR-235906
FGFR1phosphorylation
up-regulates
FGFR1
PTyr585
phosphorylation
up-regulates
FGFR18622701SIGNOR-236187
Regulator Mechanism/Effect Target SIGNOR-ID
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236179
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-98634
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236199
RPS6KA3phosphorylation

down-regulates quantity
FGFR1SIGNOR-276599
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-98626
MAPK3phosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-200884
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236203
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-235686
PRKCEphosphorylation

up-regulates
FGFR1SIGNOR-201671
ERK1/2phosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-244541
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-235682
MAPK1phosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-200880
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-98630
Gbetaphosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-270013
DUSP26dephosphorylation

down-regulates activity
FGFR1SIGNOR-277104
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236183
EPHA4phosphorylation

up-regulates activity
FGFR1SIGNOR-280007
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-235762
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236191
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236195
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-98622
MAPK14phosphorylation
img/direct_inhibition.png
down-regulates
FGFR1SIGNOR-166598
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-235906
FGFR1phosphorylation

up-regulates
FGFR1SIGNOR-236187